Multi-Level Assays of Working Memory and Psychopathology
工作记忆和精神病理学的多层次分析
基本信息
- 批准号:8691457
- 负责人:
- 金额:$ 60.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-04-16 至 2019-03-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdultAffectAnisotropyAnxietyBehaviorBiological AssayBipolar DisorderBrainCategoriesClassificationClinicalCognitiveComplexContingent Negative VariationContralateralCouplingDiagnosticDiffusionDimensionsEducational workshopElectroencephalographyEnrollmentEnsureEvaluationExclusion CriteriaFoundationsFrequenciesFunctional Magnetic Resonance ImagingFunctional disorderGoalsHippocampus (Brain)ImageImpairmentIndividual DifferencesLinkMagnetic Resonance ImagingMaintenanceMeasurementMeasuresMediatingMemory impairmentMental HealthMental disordersMethodsMissionModelingNational Institute of Mental HealthNeurobehavioral ManifestationsNeurobiologyOccupationsParticipantProcessPsychopathologyRecruitment ActivityResearchSeveritiesShort-Term MemorySpecific qualifier valueStructureSymptomsSyndromeSystemSystems DevelopmentTechnologyTestingThalamic structureThickUnited States National Institutes of HealthVariantbasecare seekingcognitive controldisabilityfunctional disabilityfusiform face areagray matterinnovationinterestlong term memorymemory processneural circuitnovel strategiespublic health relevance
项目摘要
Project Summary/Abstract
Multi-Level Assays of Working Memory and Psychopathology
The NIMH Research Domains Criteria (RDoC) initiative aims to advance understanding
of mental health through critical re-evaluation of the traditional diagnostic system and
development of alternate methods for measurement of biologically valid dimensions and
categories. The proposed project focuses on the RDoC Working Memory construct
using a "bottom-up" strategy that first determines the validity of three neural circuits
(Local Cortical, Fronto-Posterior, and Cortico-Hippocampal) using convergent measures
from electroencephalography (EEG) and magnetic resonance imaging (MRI). Next the
project determines the relations of these circuits to four working memory component
dimensions that were specified by RDoC workshops (Storage Capacity, Goal
Maintenance, Interference Control, and Long Term Memory). Finally, the project will
determine how the circuit and cognitive dimensions compare to conventionally assessed
symptoms and diagnostic categories in explaining real-world functional disability. The
project innovates by recruiting participants in two broad groups - Care Seeking and
Non-Care Seeking - to overcome the extreme-group bias affecting most previous
research that has used conventional diagnostic categories as inclusion-exclusion
criteria. By systematically testing the validity of associations across circuits, cognitive
functions, symptoms, syndromes, and real-world disability, the project will determine
how well Working Memory serves the RDoC mission, and accomplish this free of biases
associated with diagnostic categories that have limited prior research.
项目摘要/摘要
工作记忆与精神病理学的多水平测试
NIMH研究领域标准(RDoC)倡议旨在促进理解
通过对传统诊断系统的批判性重新评估和
生物有效尺寸测量的替代方法的发展
类别。拟议的项目重点是RDoC工作记忆结构
使用“自下而上”策略,首先确定三个神经回路的有效性
(局部皮质、额叶-后部和皮质-海马区)使用收敛措施
来自脑电(EEG)和磁共振成像(MRI)。接下来是
项目确定了这些电路与四个工作内存组件的关系
RDoC研讨会指定的维度(存储容量、目标
维护、干扰控制和长期记忆)。最后,该项目将
确定电路和认知维度与常规评估的比较情况
解释真实世界中的功能性残疾的症状和诊断类别。这个
该项目通过招募两大群体的参与者进行创新-寻求护理和
不寻求护理--克服影响大多数人的极端群体偏见
使用传统诊断类别作为纳入-排除项的研究
标准。通过系统地测试跨回路的关联的有效性,认知
功能、症状、症状和现实世界的残疾,该项目将确定
工作记忆如何很好地服务于RDoC任务,并无偏见地完成这一任务
与先前研究有限的诊断类别相关联。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT M BILDER其他文献
ROBERT M BILDER的其他文献
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{{ truncateString('ROBERT M BILDER', 18)}}的其他基金
Genetic, Imaging, and Cognition study of Positive Valence Systems in Psychotic Syndromes
精神病综合征正价系统的遗传、影像和认知研究
- 批准号:
10468990 - 财政年份:2018
- 资助金额:
$ 60.66万 - 项目类别:
Genetic, Imaging, and Cognition study of Positive Valence Systems in Psychotic Syndromes
精神病综合征正价系统的遗传、影像和认知研究
- 批准号:
10248440 - 财政年份:2018
- 资助金额:
$ 60.66万 - 项目类别:
Genetic, Imaging, and Cognition study of Positive Valence Systems in Psychotic Syndromes
精神病综合征正价系统的遗传、影像和认知研究
- 批准号:
10019593 - 财政年份:2018
- 资助金额:
$ 60.66万 - 项目类别:
Multi-Level Assays of Working Memory and Psychopathology
工作记忆和精神病理学的多层次分析
- 批准号:
8839303 - 财政年份:2014
- 资助金额:
$ 60.66万 - 项目类别:
Multi-Level Assays of Working Memory and Psychopathology
工作记忆和精神病理学的多层次分析
- 批准号:
8881584 - 财政年份:2014
- 资助金额:
$ 60.66万 - 项目类别:
COGNITIVE PHENOTYPING: NEUROPSYCHIATRIC THERAPEUTICS (RMI)
认知表型:神经精神治疗 (RMI)
- 批准号:
8363445 - 财政年份:2011
- 资助金额:
$ 60.66万 - 项目类别:
COGNITIVE PHENOTYPING: NEUROPSYCHIATRIC THERAPEUTICS (RMI)
认知表型:神经精神治疗 (RMI)
- 批准号:
8171066 - 财政年份:2010
- 资助金额:
$ 60.66万 - 项目类别:
COGNITIVE PHENOTYPING: NEUROPSYCHIATRIC THERAPEUTICS (RMI)
认知表型:神经精神治疗 (RMI)
- 批准号:
7955677 - 财政年份:2009
- 资助金额:
$ 60.66万 - 项目类别:
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