Multi-Level Assays of Working Memory and Psychopathology

项目概要/摘要 工作记忆和精神病理学的多水平测定 NIMH研究领域标准（RDoC）倡议旨在促进理解 通过对传统诊断系统的批判性重新评估， 开发用于测量生物有效尺寸的替代方法， 类别拟议的项目侧重于RDoC工作记忆结构 使用“自下而上”的策略，首先确定三个神经回路的有效性， （局部皮质、额后部和皮质-海马），使用收敛测量 脑电图（EEG）和磁共振成像（MRI）。接着 项目确定了这些回路与四个工作记忆成分的关系 RDoC研讨会指定的维度（存储容量、目标 维护、干扰控制和长期记忆）。最后，该项目将 确定电路和认知维度与传统评估相比如何 症状和诊断类别来解释现实世界的功能障碍。的 该项目通过招募两大群体的参与者进行创新-寻求护理和 非护理寻求-克服极端群体偏见影响大多数以前 使用常规诊断类别作为纳入-排除的研究 的搜索.通过系统地测试跨回路关联的有效性，认知 功能，症状，综合征和现实世界的残疾，该项目将确定 工作记忆服务RDoC使命的效果如何，并在没有偏见的情况下完成这一任务 与先前研究有限的诊断类别相关。

Project Summary/Abstract Multi-Level Assays of Working Memory and Psychopathology The NIMH Research Domains Criteria (RDoC) initiative aims to advance understanding of mental health through critical re-evaluation of the traditional diagnostic system and development of alternate methods for measurement of biologically valid dimensions and categories. The proposed project focuses on the RDoC Working Memory construct using a "bottom-up" strategy that first determines the validity of three neural circuits (Local Cortical, Fronto-Posterior, and Cortico-Hippocampal) using convergent measures from electroencephalography (EEG) and magnetic resonance imaging (MRI). Next the project determines the relations of these circuits to four working memory component dimensions that were specified by RDoC workshops (Storage Capacity, Goal Maintenance, Interference Control, and Long Term Memory). Finally, the project will determine how the circuit and cognitive dimensions compare to conventionally assessed symptoms and diagnostic categories in explaining real-world functional disability. The project innovates by recruiting participants in two broad groups - Care Seeking and Non-Care Seeking - to overcome the extreme-group bias affecting most previous research that has used conventional diagnostic categories as inclusion-exclusion criteria. By systematically testing the validity of associations across circuits, cognitive functions, symptoms, syndromes, and real-world disability, the project will determine how well Working Memory serves the RDoC mission, and accomplish this free of biases associated with diagnostic categories that have limited prior research.