Multi-Level Assays of Working Memory and Psychopathology

项目摘要/摘要 工作记忆与精神病理学的多水平测试 NIMH研究领域标准(RDoC)倡议旨在促进理解 通过对传统诊断系统的批判性重新评估和 生物有效尺寸测量的替代方法的发展 类别。拟议的项目重点是RDoC工作记忆结构 使用“自下而上”策略，首先确定三个神经回路的有效性 (局部皮质、额叶-后部和皮质-海马区)使用收敛措施 来自脑电(EEG)和磁共振成像(MRI)。接下来是 项目确定了这些电路与四个工作内存组件的关系 RDoC研讨会指定的维度(存储容量、目标 维护、干扰控制和长期记忆)。最后，该项目将 确定电路和认知维度与常规评估的比较情况 解释真实世界中的功能性残疾的症状和诊断类别。这个 该项目通过招募两大群体的参与者进行创新-寻求护理和 不寻求护理--克服影响大多数人的极端群体偏见 使用传统诊断类别作为纳入-排除项的研究 标准。通过系统地测试跨回路的关联的有效性，认知 功能、症状、症状和现实世界的残疾，该项目将确定 工作记忆如何很好地服务于RDoC任务，并无偏见地完成这一任务 与先前研究有限的诊断类别相关联。

Project Summary/Abstract Multi-Level Assays of Working Memory and Psychopathology The NIMH Research Domains Criteria (RDoC) initiative aims to advance understanding of mental health through critical re-evaluation of the traditional diagnostic system and development of alternate methods for measurement of biologically valid dimensions and categories. The proposed project focuses on the RDoC Working Memory construct using a "bottom-up" strategy that first determines the validity of three neural circuits (Local Cortical, Fronto-Posterior, and Cortico-Hippocampal) using convergent measures from electroencephalography (EEG) and magnetic resonance imaging (MRI). Next the project determines the relations of these circuits to four working memory component dimensions that were specified by RDoC workshops (Storage Capacity, Goal Maintenance, Interference Control, and Long Term Memory). Finally, the project will determine how the circuit and cognitive dimensions compare to conventionally assessed symptoms and diagnostic categories in explaining real-world functional disability. The project innovates by recruiting participants in two broad groups - Care Seeking and Non-Care Seeking - to overcome the extreme-group bias affecting most previous research that has used conventional diagnostic categories as inclusion-exclusion criteria. By systematically testing the validity of associations across circuits, cognitive functions, symptoms, syndromes, and real-world disability, the project will determine how well Working Memory serves the RDoC mission, and accomplish this free of biases associated with diagnostic categories that have limited prior research.