Human Translational Applications Core (HTA - Core) (7 of 8)

人类翻译应用核心（P30-HTAC）支持神经精神病学联盟 表型组学（CNP）通过提供三个综合单元的服务：（1）人类招募和表型分析 股;（2）神经影像股;和（3）统计和数据库管理股。人力招聘 和表型分析部门通过招募所有人类受试者并进行所有诊断， 行为，个性和认知数据所需的组件3和4。人类样本包括 一组2000名健康人（称为“LA 2K”），和三个诊断组各100名个体。 团体（包括诊断为精神分裂症、双相情感障碍和注意力不集中的人） 缺陷/多动障碍），包括欧洲和西班牙裔/拉丁裔血统的人。的 神经影像科将负责进行结构和功能神经影像方面的检查 （包括结构磁共振成像、功能磁共振成像和扩散成像） 张量成像），采集所有相关数据并提供分析 在这些领域的研究人员。统计和数据库管理股提供 一系列统计资源协调、数据库管理和项目管理功能， 其他CNP组件。P30-HTAC中的每个单元都保持标准，以确保 CNP数据。P30-HTAC的三个单元共同为CNP提供高质量的服务， 这是任何单个项目都难以实现的。P30-HTAC进一步整合了这些 服务，以维持CNP内各组成部分之间的协同作用和互动。P30-HTAC还 其科学目标超出其服务角色：其单位积极寻求开发人类新方法， 行为和认知评估、神经影像学和统计学方法，用于最佳表型定义 以及鉴定表型和基因型之间的关系。

The Human Translational Applications Core (P30-HTAC) supports the Consortium for Neuropsychiatric Phenomics (CNP) by providing services of three integrated units: (1) Human Recruitment and Phenotyping Unit; (2) Neuroimaging Unit; and (3) Statistics and Database Management Unit. The Human Recruitment and Phenotyping Unit serves the CNP by recruiting all human subjects and conducting all diagnostic, behavioral, personality, and cognitive data needed by Components 3 and 4. The human samples include a group of 2000 healthy people (referred to as the "LA2K"), and 100 individuals in each of three diagnostic groups (comprising people with the diagnoses of schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder), including people of both European and Hispanic/Latino ancestries. The Neuroimaging Unit will be responsible for sthe conduct of structural and functional neuroimaging aspects (including structural magnetic resonance imaging, functional magnetic resonance imaging, and diffusion tensor imaging) required for Components 3 and 4, acquiring all relevant data and providing analysis expertise to investigators within these components. The Statistics and Database Management Unit provides a range of statistical resource coordination, database management, and project management functions to all other CNP components. Each of the units within the P30-HTAC maintains standards to assure quality of CNP data. Collectively the three units of the P30-HTAC provide high quality services to the CNP with efficiency difficult for any individual project to achieve. The P30-HTAC further integrates delivery of these services to sustain the synergy and interactions across components within the CNP. The P30-HTAC also has scientific aims beyond its service roles: its units actively seeks to develop new methods in human behavioral and cognitive assessment, neuroimaging, and statistical methods for optimal phenotype definition and identification of relations between phenotypes and genotypes.