COGNITIVE PHENOTYPING: NEUROPSYCHIATRIC THERAPEUTICS (RMI)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 认知表型组学探索中心(CCP)旨在加快跨症状和跨物种的认知表型的识别和有效测量，以促进神经精神疗法的跨学科研究。认知异常已经在所有主要的神经精神障碍中被发现，为基因组研究和临床试验提供了定量的表型，并提供了与神经系统模型的强大桥梁关系。CCP将反复改进跨学科研究中的认知表型，使用神经行为、神经成像和神经心理药理学方法，提供生理内表型的翻译验证。CCP将协调加州大学洛杉矶分校和其他地方的一大批专家的活动，以：(1)生成跨无序和跨物种的表型目录；(2)开发表型选择算法以确定最有希望的候选研究；(3)设计用于经验数据表示、数据挖掘和假设检验的表型数据库；以及(4)支持概念验证试点项目。为了推进这些目标，CCP将启动以下核心服务：高吞吐量认知表型鉴定；神经成像；以及翻译神经精神药理学。CCP最初将利用加州大学洛杉矶分校的校园资源，在以下领域提供桥梁基础设施和专业知识：基因组学、药物基因组学和统计遗传学；生物统计学和心理计量学；生物信息学；临床试验设计和监管事务；以及生物伦理学。CCP旨在克服神经精神综合征治疗方法的发现瓶颈，这些瓶颈是由使用传统的行为“症状”表型引起的，这些表型是不同的和重叠的，很难转化为基础研究。长期目标是建立一个成熟的CCP，为国际研究界提供有效、有效的表型分析；一个与基因组学、蛋白质组学和其他生物学知识库链接的认知表现学数据库；以及神经精神疗法跨学科研究的新战略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The exploratory Center for Cognitive Phenomics (CCP) aims to accelerate identification and efficient measurement of cognitive phenotypes across syndromes and across species to advance interdisciplinary research on neuropsychiatric therapeutics. Cognitive abnormalities have been identified in all major neuropsychiatric disorders, offer quantitative phenotypes for genomic studies and clinical trials, and provide strong bridging relations to neural systems models. The CCP will iteratively refine cognitive phenotypes in interdisciplinary research using neurobehavioral, neuroimaging, and neuropsychopharmacological approaches to provide translational validation of physiological endophenotypes. The CCP will coordinate activities of a large group of experts at UCLA and elsewhere to: (1) generate cross-disorder and cross-species catalogs of phenotypes; (2) develop a phenotype selection algorithm to identify the most promising candidates for research; (3) design a phenomics database for empirical data representation, data mining, and hypothesis testing; and (4) support proof of- concept pilot projects. To advance these aims the CCP will initiate core services for: High Throughput Cognitive Phenotyping; Neuroimaging; and Translational Neuropsychopharmacology. The CCP will initially leverage UCLA campus-wide resources to provide bridging infrastructure and expertise in: Genomics, Pharmacogenomics and Statistical Genetics; Biostatistics and Psychometrics; Bioinformatics; Clinical Trial Design and Regulatory Affairs; and Bioethics. The CCP aims to overcome bottlenecks in the discovery of treatments for neuropsychiatric syndromes that are caused by the use of traditional behavioral "symptom" phenotypes, which are heterogeneous and overlapping, and difficult to translate to basic research. The long-term goal is establishment of a mature CCP that will provide the international research community with efficient, well validated phenotype assays; a cognitive phenomics data repository linked to genomics, proteomics, and other biological knowledge-bases; and novel strategies for interdisciplinary research on neuropsychiatric therapeutics.