Human Translational Applications Core (HTA - Core) (7 of 8)

人类翻译应用核心(P30-HTAC)支持神经精神病学联盟 通过提供三个综合单元的服务来进行表型组学(CNP)：(1)人类招募和表型分析 (2)神经成像股；(3)统计和数据库管理股。人力资源招聘 表型分型股通过招募所有人类受试者并进行所有诊断， 组件3和4所需的行为、个性和认知数据。人体样本包括 由2000名健康人组成的团体(简称“LA2K”)，分别以100人为三个诊断对象 小组(包括被诊断为精神分裂症、双相情感障碍和注意力集中的人 缺陷/多动障碍)，包括欧洲人和西班牙裔/拉丁裔祖先的人。这个 神经成像股将负责进行结构和功能方面的神经成像 (包括结构磁共振成像、功能磁共振成像和扩散成像 3和4所需的张量成像)，获取所有相关数据并提供分析 向这些部门内的调查人员提供专业知识。统计和数据库管理股提供 向所有人提供一系列统计资源协调、数据库管理和项目管理功能 其他CNP组件。P30-HTAC内的每个单元都保持标准，以确保质量 CNP数据。P30-HTAC的三个单位共同为CNP提供高质量的服务 效率对于任何单个项目来说都很难实现。P30-HTAC进一步集成了这些交付 用于维持CNP内各组件之间的协同和交互的服务。P30-HTAC还 有超越其服务角色的科学目标：其单位积极寻求开发人类的新方法 用于最佳表型定义的行为和认知评估、神经成像和统计方法 以及表型和基因型之间的关系的鉴定。

The Human Translational Applications Core (P30-HTAC) supports the Consortium for Neuropsychiatric Phenomics (CNP) by providing services of three integrated units: (1) Human Recruitment and Phenotyping Unit; (2) Neuroimaging Unit; and (3) Statistics and Database Management Unit. The Human Recruitment and Phenotyping Unit serves the CNP by recruiting all human subjects and conducting all diagnostic, behavioral, personality, and cognitive data needed by Components 3 and 4. The human samples include a group of 2000 healthy people (referred to as the "LA2K"), and 100 individuals in each of three diagnostic groups (comprising people with the diagnoses of schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder), including people of both European and Hispanic/Latino ancestries. The Neuroimaging Unit will be responsible for sthe conduct of structural and functional neuroimaging aspects (including structural magnetic resonance imaging, functional magnetic resonance imaging, and diffusion tensor imaging) required for Components 3 and 4, acquiring all relevant data and providing analysis expertise to investigators within these components. The Statistics and Database Management Unit provides a range of statistical resource coordination, database management, and project management functions to all other CNP components. Each of the units within the P30-HTAC maintains standards to assure quality of CNP data. Collectively the three units of the P30-HTAC provide high quality services to the CNP with efficiency difficult for any individual project to achieve. The P30-HTAC further integrates delivery of these services to sustain the synergy and interactions across components within the CNP. The P30-HTAC also has scientific aims beyond its service roles: its units actively seeks to develop new methods in human behavioral and cognitive assessment, neuroimaging, and statistical methods for optimal phenotype definition and identification of relations between phenotypes and genotypes.