Center for Adaptive Neurotechnologies

自适应神经技术中心

• 批准号: 8742704
• 负责人: Jonathan Rickel Wolpaw
• 金额: $ 164.84万
• 依托单位: NYSDOH/HEALTH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-10 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742704
• 关键词: Achievement; Algorithms; Base of the Brain; Brain; Clinical; Clinical Engineering; Computer software; Development; Disease; Educational Curriculum; Educational workshop; Electroencephalography; Engineering; Foundations; Functional disorder; Journals; Maps; Methods; Modeling; Motor; Nervous System Physiology; Nervous system structure; Neuraxis; Operant Conditioning; Pathway interactions; Process; Protocols documentation; Rehabilitation therapy; Research Infrastructure; Resolution; Scientist; Signal Transduction; Spinal; Stroke; Substance abuse problem; Surface; System; Time; Training; Translations; Trauma recovery; Work; addiction; brain computer interface; clinical application; craving; disability; emotion regulation; experience; improved; insight; meetings; motor control; nervous system disorder; neuromuscular; neurotechnology; new technology; novel; novel therapeutics; public health relevance; web site

DESCRIPTION (provided by applicant): Wadsworth scientists and engineers are building a unique technological infrastructure that supports real time interactions with the central nervous system (CNS). They are using it to produce important new scientific insights and novel clinical methods, and they are beginning to disseminate these achievements to others. The proposed Center for Adaptive Neurotechnologies will continue and expand this effort, strengthen its focus on clinical translation, and accelerate dissemination of the new technologies. It has five specific aims. Aim 1 will develop and validate new operant conditioning protocols that can modify specific spinal and corticospinal CNS pathways to induce and guide beneficial (i.e., rehabilitative) plasticity in the CNS. These protocols will also be incorporated into a compact and robust unit to enable widespread use of this new therapeutic method in people with motor disabilities. Aim 2 will develop and validate electroencephalography(EEG)-based brain-computer interface (BCI) systems that can improve important CNS functions, such as motor control in people with severe neuromuscular disabilities (e.g., stroke) and emotion regulation in people with addiction disorders (thereby reducing craving and substance abuse). Aim 3 will develop and validate methods that use electrocorticographic (ECoG) signals from the cortical surface to localize and characterize brain processes with temporal and spatial resolution beyond that now possible. This work will develop novel algorithms for modeling, co-registration, representation, and reduction of ECoG signals; and will incorporate them into real-time software for detecting, mapping, and interacting with the brain processes underlying specific functions and dysfunctions. Aim 4 will create a novel interdisciplinary training curriculum that provides a theoretical foundation in adaptive neurotechnologies and practical experience in applying them to important scientific and clinical applications. This curriculum will be incorporated into training courses and workshops. Aim 5 will develop and support dissemination channels for adaptive neurotechnologies, including: the highly interactive Center website; review articles in scientific, engineering, and clinical journals; and presentations and workshops at scientific and clinical meetings.

描述(申请人提供)：沃兹沃斯的科学家和工程师正在建设一种独特的技术基础设施，支持与中枢神经系统(CNS)的实时交互。他们正在利用它来产生重要的新科学见解和新的临床方法，并开始将这些成果传播给其他人。拟议的自适应神经技术中心将继续并扩大这一努力，加强对临床翻译的关注，并加快新技术的传播。它有五个具体目标。目的1将开发和验证新的操作性条件反射方案，这些方案可以改变特定的脊髓和皮质脊髓中枢神经系统通路，以诱导和引导中枢神经系统中有益的(即康复的)可塑性。这些方案还将被纳入一个紧凑而坚固的单元，使这种新的治疗方法能够在运动障碍者中广泛使用。Aim 2将开发和验证基于脑电(EEG)的脑机接口(BCI)系统，该系统可以改善重要的中枢神经功能，如患有严重神经肌肉障碍(如中风)的人的运动控制和有成瘾障碍的人的情绪调节(从而减少渴望和药物滥用)。AIM 3将开发和验证使用来自皮质表面的皮层脑电(ECoG)信号来定位和表征大脑过程的方法，其时间和空间分辨率超过了现在可能实现的水平。这项工作将开发用于ECoG信号的建模、联合配准、表示和还原的新算法；并将它们整合到实时软件中，用于检测、映射和与潜在的特定功能和功能障碍的大脑过程交互。AIM 4将创建一个新的跨学科培训课程，提供自适应神经技术的理论基础和将其应用于重要科学和临床应用的实践经验。这一课程将纳入培训课程和讲习班。AIM 5将开发和支持自适应神经技术的传播渠道，包括：高度互动的中心网站；科学、 工程学和临床杂志；以及在科学和临床会议上的演讲和研讨会。