Center for Adaptive Neurotechnologies

自适应神经技术中心

• 批准号: 10456334
• 负责人: Jonathan Rickel Wolpaw
• 金额: $ 107.57万
• 依托单位: ALBANY RESEARCH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-10 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456334
• 关键词: Achievement; Advisory Committees; Affect; Amaze; Area; Behavior; Brain; Cerebral Palsy; Clinical; Collaborations; Course Content; Development; Disease; Educational workshop; Electric Stimulation; Electrodes; Engineering; Ensure; Etiology; Functional disorder; Goals; Grant; Impairment; Industry; Institution; International; Intervention; Logistics; Maps; Methods; Minor; Molecular Biology; Nervous System Physiology; Nervous system structure; Neuraxis; Neuromuscular Diseases; Neuronal Plasticity; Operant Conditioning; Outcome; Persons; Protocols documentation; Rattus; Recovery; Recovery of Function; Reporting; Research Personnel; Scientist; Services; Site; Spinal cord injury; Stroke; Structure; Sum; Support System; System; Technology; Therapeutic; Therapeutic Studies; Time; Training; Training Support; Translating; United States; Work; base; clinical translation; design; dissemination strategy; functional restoration; imaging modality; improved; improved functioning; injury recovery; insight; nervous system disorder; neurotechnology; new technology; novel; novel therapeutics; spinal reflex; success; technology research and development; web site; wireless implant

NCAN Summary Engineers and scientists at the National Center for Adaptive Neurotechnologies (NCAN) are creating technologies that can guide CNS plasticity to enhance recovery for people with spinal cord injury, stroke, or other neuromuscular disorders. NCAN is producing new insights and novel therapies and disseminating them to engineers, scientists, and clinicians everywhere. This renewal application proposes to enhance NCAN technologies, apply them to critical problems, hasten their clinical translation, and increase their wider impact. Aim 1 will develop a wholly implanted wireless system for long-term 24/7 interactive studies in freely moving rats. It will use this new system for the first study of the molecular biology underlying spinal reflex operant conditioning, a promising new therapy that can enhance recovery after spinal cord injury or other disorders. This novel system will support many kinds of long-term real-time interactive interventions for NCAN and for other researchers. Aim 2 will develop a robust clinical system that supports a wide variety of protocols designed to target beneficial plasticity to key CNS sites and is suitable for widespread clinical use. It will optimize this new system in collaboration with clinical therapists and provide it for therapeutic studies focused on spinal cord injury, cerebral palsy, and stroke. Aim 3 will develop a clinically practical system that uses electrical stimulation via electrocorticographic/stereoencephalographic electrodes to map brain networks, define causality between areas, and ultimately, to target plasticity that restores function impaired by stroke or other disorders. It will thereby create a new imaging modality that can reveal point-to-point functional connections in the brain, relate them to behavior, and enable their therapeutic modulation. Aim 4 will provide training in and promote dissemination of NCAN neurotechnologies. It will enhance NCAN's 3-week short course curriculum, continue to offer many topic-specific workshops in appropriate venues, and provide materials and guidance that enable other institutions to create their own topic-specific courses. It will disseminate and support training materials and technologies through the NCAN website and other mechanisms. Aim 5 comprises the administration that supports all NCAN activities. This new grant period will include further development of major successes of the first grant period, initiation of new technologies and novel therapeutic protocols, strong synergistic interactions among the Aims, intensive collaborations with industry, and growing focus on clinical translation of NCAN technologies and protocols. In summary, NCAN will continue to create novel neurotechnologies, define their mechanisms, translate them into widespread use, and provide training and dissemination that enable and encourage other scientists, engineers, and clinicians to join in developing these technologies and applying them to major scientific and clinical problems. Thus, NCAN will continue to perform, encourage, and enable studies that elucidate CNS function and dysfunction, and that realize effective new therapies for devastating neurological disorders.

n可以摘要 国家自适应神经技术中心（NCAN）的工程师和科学家正在创建技术 可以指导CNS可塑性以增强脊髓损伤，中风或其他神经肌肉的恢复 疾病。 NCAN正在产生新的见解和新颖的疗法，并将其传播给工程师，科学家， 到处都是临床医生。此续签应用建议以增强NCAN技术，将其应用于 关键问题，加快其临床翻译，并增加其更广泛的影响。 AIM 1将开发一个完全植入的无线系统，用于长期24/7的交互式研究 老鼠。它将使用该新系统进行首次研究脊柱反射操作依据的分子生物学 调理，一种有希望的新疗法，可以在脊髓损伤或其他疾病后增强恢复。这 新型系统将为NCAN和其他其他类型的实时互动干预措施提供支持 研究人员。 AIM 2将开发出强大的临床系统，该系统支持各种旨在的协议 将有益的可塑性靶向关键的CNS站点，适合广泛的临床用途。它将优化这个新的 系统与临床治疗师合作，并为脊髓损伤的治疗研究提供 脑瘫和中风。 AIM 3将开发一个临床实用的系统，该系统使用电气刺激通过 电视学/立体铭文学电极以绘制脑网络，定义区域之间的因果关系， 最终，靶向恢复中风或其他疾病受损功能的可塑性。从而创建 一种可以揭示大脑中点对点功能连接的新成像方式，将它们与行为相关联， 并启用其治疗调节。 AIM 4将提供培训并促进NCAN的传播 神经技术。它将增强NCAN的3周短期课程，继续提供许多特定于主题的课程 在适当的场所的讲习班，并提供材料和指导，使其他机构能够创建其 自己的特定于主题的课程。它将通过NCAN传播和支持培训材料和技术 网站和其他机制。 AIM 5包括支持所有NCA活动的政府。 这个新的赠款期将包括进一步发展第一个赠款期的重大成功，启动 新技术和新型治疗方案，目标之间的强烈协同互动，密集 与行业的合作，并越来越关注NCAN技术和协议的临床翻译。 总而言之，NCAN将继续创建新颖的神经技术，定义其机制，将其转化为 广泛使用，并提供培训和传播，使其他科学家，工程师， 临床医生加入开发这些技术并将其应用于重大科学和临床问题。 因此，NCAN将继续执行，鼓励和启用研究CNS功能和功能障碍的研究， 这实现了毁灭性神经系统疾病的有效新疗法。