Center for Adaptive Neurotechnologies
自适应神经技术中心
基本信息
- 批准号:9803919
- 负责人:
- 金额:$ 155.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-10 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:AchievementAdvisory CommitteesAffectAmazeAreaBehaviorBrainCerebral PalsyClinicalCollaborationsCourse ContentDevelopmentDiseaseEducational workshopElectric StimulationElectrodesEngineeringEnsureEtiologyFunctional disorderGoalsGrantImpairmentImplantIndustryInjuryInstitutionInternationalInterventionLogisticsMapsMethodsMinorMolecular BiologyNervous System PhysiologyNervous system structureNeuraxisNeuromuscular DiseasesOperant ConditioningOutcomeProtocols documentationRattusRecoveryRecovery of FunctionReportingResearch PersonnelScientistServicesSiteSpinal cord injuryStrokeStructureSumSupport SystemSystemTechnologyTherapeuticTherapeutic StudiesTimeTrainingTraining SupportTranslatingUnited StatesWireless TechnologyWorkbaseclinical translationdesignfunctional restorationimaging modalityimprovedimproved functioninginsightnervous system disorderneurotechnologynew technologynovelnovel therapeuticsspinal reflexsuccesstechnology research and developmentweb site
项目摘要
NCAN Summary
Engineers and scientists at the National Center for Adaptive Neurotechnologies (NCAN) are creating technologies
that can guide CNS plasticity to enhance recovery for people with spinal cord injury, stroke, or other neuromuscular
disorders. NCAN is producing new insights and novel therapies and disseminating them to engineers, scientists,
and clinicians everywhere. This renewal application proposes to enhance NCAN technologies, apply them to
critical problems, hasten their clinical translation, and increase their wider impact.
Aim 1 will develop a wholly implanted wireless system for long-term 24/7 interactive studies in freely moving
rats. It will use this new system for the first study of the molecular biology underlying spinal reflex operant
conditioning, a promising new therapy that can enhance recovery after spinal cord injury or other disorders. This
novel system will support many kinds of long-term real-time interactive interventions for NCAN and for other
researchers. Aim 2 will develop a robust clinical system that supports a wide variety of protocols designed to
target beneficial plasticity to key CNS sites and is suitable for widespread clinical use. It will optimize this new
system in collaboration with clinical therapists and provide it for therapeutic studies focused on spinal cord injury,
cerebral palsy, and stroke. Aim 3 will develop a clinically practical system that uses electrical stimulation via
electrocorticographic/stereoencephalographic electrodes to map brain networks, define causality between areas,
and ultimately, to target plasticity that restores function impaired by stroke or other disorders. It will thereby create
a new imaging modality that can reveal point-to-point functional connections in the brain, relate them to behavior,
and enable their therapeutic modulation. Aim 4 will provide training in and promote dissemination of NCAN
neurotechnologies. It will enhance NCAN's 3-week short course curriculum, continue to offer many topic-specific
workshops in appropriate venues, and provide materials and guidance that enable other institutions to create their
own topic-specific courses. It will disseminate and support training materials and technologies through the NCAN
website and other mechanisms. Aim 5 comprises the administration that supports all NCAN activities.
This new grant period will include further development of major successes of the first grant period, initiation of
new technologies and novel therapeutic protocols, strong synergistic interactions among the Aims, intensive
collaborations with industry, and growing focus on clinical translation of NCAN technologies and protocols.
In summary, NCAN will continue to create novel neurotechnologies, define their mechanisms, translate them into
widespread use, and provide training and dissemination that enable and encourage other scientists, engineers,
and clinicians to join in developing these technologies and applying them to major scientific and clinical problems.
Thus, NCAN will continue to perform, encourage, and enable studies that elucidate CNS function and dysfunction,
and that realize effective new therapies for devastating neurological disorders.
NCAN摘要
国家自适应神经技术中心(NCAN)的工程师和科学家正在创造技术
它可以引导中枢神经系统的可塑性,以促进脊髓损伤、中风或其他神经肌肉疾病患者的康复。
紊乱NCAN正在产生新的见解和新的疗法,并将其传播给工程师,科学家,
和各地的临床医生。此更新申请建议增强NCAN技术,将其应用于
关键问题,加速其临床转化,并增加其更广泛的影响。
Aim 1将开发一种完全植入的无线系统,用于自由移动的长期24/7交互式研究
大鼠它将使用这个新系统进行脊髓反射操作性分子生物学的首次研究。
条件反射是一种很有前途的新疗法,可以增强脊髓损伤或其他疾病后的恢复。这
一个新的系统将支持多种长期的实时互动干预NCAN和其他
研究人员Aim 2将开发一个强大的临床系统,支持各种各样的协议,
将有益可塑性靶向于关键CNS部位,并适合于广泛的临床应用。它将优化这个新的
系统与临床治疗师合作,并提供它的治疗研究集中在脊髓损伤,
脑瘫和中风Aim 3将开发一种临床实用的系统,
皮层电图/脑立体图电极来绘制大脑网络,定义区域之间的因果关系,
并最终以恢复因中风或其他疾病而受损的功能的可塑性为目标。它将由此创造
一种新的成像方式,可以揭示大脑中点对点的功能连接,将它们与行为联系起来,
并使其能够进行治疗调节。目标4将提供关于NCAN的培训并促进其传播
神经技术它将加强NCAN的3周短期课程,继续提供许多特定主题的课程,
讲习班,并提供材料和指导,使其他机构能够建立自己的
自己的专题课程。它将通过国家气候行动网络传播和支持培训材料和技术
网站和其他机制。目标5包括支持所有国家禁毒理事会活动的行政部门。
这一新的资助期将包括进一步发展第一个资助期的主要成就,
新技术和新的治疗方案,目标之间的强协同作用,
与行业合作,并日益关注NCAN技术和协议的临床翻译。
总之,NCAN将继续创造新的神经技术,定义它们的机制,将它们转化为
广泛使用,并提供培训和传播,使其他科学家,工程师,
和临床医生一起开发这些技术,并将其应用于重大的科学和临床问题。
因此,NCAN将继续执行,鼓励和实现阐明CNS功能和功能障碍的研究,
并为毁灭性的神经系统疾病实现有效的新疗法。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Jonathan Rickel Wolpaw其他文献
Jonathan Rickel Wolpaw的其他文献
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{{ truncateString('Jonathan Rickel Wolpaw', 18)}}的其他基金
Corticospinal control of spinal reflex plasticity
皮质脊髓对脊髓反射可塑性的控制
- 批准号:
10670047 - 财政年份:2018
- 资助金额:
$ 155.74万 - 项目类别:
Dynamics and Causal Functions of Large-Scale Cortical and Subcortical Networks
大规模皮层和皮层下网络的动力学和因果函数
- 批准号:
9789700 - 财政年份:2018
- 资助金额:
$ 155.74万 - 项目类别:
Corticospinal control of spinal reflex plasticity
皮质脊髓对脊髓反射可塑性的控制
- 批准号:
10041767 - 财政年份:2018
- 资助金额:
$ 155.74万 - 项目类别:
Corticospinal control of spinal reflex plasticity
皮质脊髓对脊髓反射可塑性的控制
- 批准号:
10295134 - 财政年份:2018
- 资助金额:
$ 155.74万 - 项目类别:
Technology Research and Development Project 1 (Guiding Beneficial Plasticity)
技术研发项目1(引导有益可塑性)
- 批准号:
10456336 - 财政年份:2014
- 资助金额:
$ 155.74万 - 项目类别:
Operant Conditioning of Spinal Reflexes to Improve Function after Nerve Injury
脊髓反射的操作性调节以改善神经损伤后的功能
- 批准号:
8729102 - 财政年份:2014
- 资助金额:
$ 155.74万 - 项目类别:
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