Center for Adaptive Neurotechnologies

NCAN摘要 国家自适应神经技术中心(NCAN)的工程师和科学家正在创造技术 这可以引导中枢神经系统的可塑性，以促进脊髓损伤、中风或其他神经肌肉疾病患者的恢复 精神错乱。NCAN正在产生新的见解和新的疗法，并将它们传播给工程师、科学家、 以及各地的临床医生。此续订申请建议增强NCAN技术，将其应用于 关键问题，加速其临床转化，并增加其更广泛的影响。 AIM 1将开发一种完全植入的无线系统，用于在自由移动中进行长期24/7互动研究 老鼠。它将利用这一新系统首次研究脊髓反射操纵器背后的分子生物学。 条件反射，一种很有前途的新疗法，可以促进脊髓损伤或其他疾病后的恢复。这 新系统将支持NCAN和其他各种类型的长期实时交互干预 研究人员。AIM 2将开发一个强大的临床系统，支持多种方案，旨在 靶向中枢神经系统关键部位的有益可塑性，适合临床广泛应用。它将优化这一新的 系统与临床治疗师合作，并为侧重于脊髓损伤的治疗研究提供该系统， 脑性瘫痪和中风。目标3将开发一种临床实用的系统，它通过 皮质脑电/立体脑电极图绘制大脑网络图，定义区域之间的因果关系， 最终，目标是恢复因中风或其他疾病而受损的功能的可塑性。它将因此创造出 一种新的成像模式，可以揭示大脑中点对点的功能连接，将它们与行为联系起来， 并使它们能够进行治疗调节。目标4将提供NCAN方面的培训并促进其传播 神经科技。它将加强NCAN为期3周的短期课程，继续提供许多特定主题 在适当的地点举办讲习班，并提供材料和指导，使其他机构能够创建他们的 开设特定主题的课程。它将通过NCAN传播和支持培训材料和技术 网站和其他机制。AIM 5由支持所有NCAN活动的行政部门组成。 这一新的授权期将包括进一步发展第一个授权期的重大成功，启动 新技术和新的治疗方案，目标之间的强协同互动，密集 与业界合作，并日益关注NCAN技术和协议的临床翻译。 总之，NCAN将继续创造新的神经技术，定义它们的机制，将它们转化为 广泛使用，并提供培训和传播，使其他科学家、工程师、 和临床医生一起开发这些技术，并将它们应用于重大科学和临床问题。 因此，NCAN将继续开展、鼓励和支持阐明中枢神经系统功能和功能障碍的研究， 为毁灭性的神经疾病实现有效的新疗法。

NCAN Summary Engineers and scientists at the National Center for Adaptive Neurotechnologies (NCAN) are creating technologies that can guide CNS plasticity to enhance recovery for people with spinal cord injury, stroke, or other neuromuscular disorders. NCAN is producing new insights and novel therapies and disseminating them to engineers, scientists, and clinicians everywhere. This renewal application proposes to enhance NCAN technologies, apply them to critical problems, hasten their clinical translation, and increase their wider impact. Aim 1 will develop a wholly implanted wireless system for long-term 24/7 interactive studies in freely moving rats. It will use this new system for the first study of the molecular biology underlying spinal reflex operant conditioning, a promising new therapy that can enhance recovery after spinal cord injury or other disorders. This novel system will support many kinds of long-term real-time interactive interventions for NCAN and for other researchers. Aim 2 will develop a robust clinical system that supports a wide variety of protocols designed to target beneficial plasticity to key CNS sites and is suitable for widespread clinical use. It will optimize this new system in collaboration with clinical therapists and provide it for therapeutic studies focused on spinal cord injury, cerebral palsy, and stroke. Aim 3 will develop a clinically practical system that uses electrical stimulation via electrocorticographic/stereoencephalographic electrodes to map brain networks, define causality between areas, and ultimately, to target plasticity that restores function impaired by stroke or other disorders. It will thereby create a new imaging modality that can reveal point-to-point functional connections in the brain, relate them to behavior, and enable their therapeutic modulation. Aim 4 will provide training in and promote dissemination of NCAN neurotechnologies. It will enhance NCAN's 3-week short course curriculum, continue to offer many topic-specific workshops in appropriate venues, and provide materials and guidance that enable other institutions to create their own topic-specific courses. It will disseminate and support training materials and technologies through the NCAN website and other mechanisms. Aim 5 comprises the administration that supports all NCAN activities. This new grant period will include further development of major successes of the first grant period, initiation of new technologies and novel therapeutic protocols, strong synergistic interactions among the Aims, intensive collaborations with industry, and growing focus on clinical translation of NCAN technologies and protocols. In summary, NCAN will continue to create novel neurotechnologies, define their mechanisms, translate them into widespread use, and provide training and dissemination that enable and encourage other scientists, engineers, and clinicians to join in developing these technologies and applying them to major scientific and clinical problems. Thus, NCAN will continue to perform, encourage, and enable studies that elucidate CNS function and dysfunction, and that realize effective new therapies for devastating neurological disorders.