Wireless Pulse Oximetry (WiPOX) for Diagnosing Intra-Operative Ischemia

用于诊断术中缺血的无线脉搏血氧仪 (WiPOX)

基本信息

批准号：
8702683
负责人：
MAROM BIKSON
金额：
$ 7.65万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8702683
关键词：
Algorithmic Software Algorithms Amendment Anastomosis - action Animals Biomedical Engineering Blood Blood flow Cities Clinical Clinical Trials Collaborations Complex Coronary Artery Bypass Data Development Devices Diagnosis Diagnostic Electronics Engineering Ensure Esophageal Esophagectomy Excision Extravasation Feedback Fingers Hand Head Healed Hospitalization Hospitals Human IACUC Institutional Review Boards Intention Intraoperative Monitoring Ischemia Joints Malignant neoplasm of esophagus Measurement Measures Mechanics Memorial Sloan-Kettering Cancer Center Methods Modification Monitor Morbidity - disease rate Morphologic artifacts Motion New York Noise Operating Rooms Operative Surgical Procedures Organ Organ Transplantation Outcome Output Oxygen saturation measurement Patients Performance Peripheral Physiologic pulse Plastic Surgical Procedures Postoperative Period Preclinical Testing Process Protocols documentation Pulse Oximetry Pulse Rates Reading Relative (related person)Safety Site Solid Speed Surgeon Surgical Flaps System Tactile Techniques Testing Therapeutic Intervention Time Tissue Viability Tissues Touch sensation Training Validation Visual Wireless Technology Work Writing base college cost design design and construction healing improved innovation instrument meetings minimally invasive mortality novel operation optical sensor preclinical study pressure prevent public health relevance reconstruction research clinical testing sensor signal processing tissue oxygenation tool transmission process user-friendly wound

项目摘要

DESCRIPTION (provided by applicant): Tissue ischemia is a major cause of wound dehiscence or anastomotic leakage resulting in significant morbidity and mortality and occurs at a rate of 15 to 25%. Although measurement of systemic blood oxygenation status by pulse oximetry on the finger is a mandatory requirement for every single patient while in the hospital, there are no devices or methods available to measure tissue oxygenation following complex surgical resections and reconstructions in the operating room. Increasingly, surgical procedures are performed by minimally invasive techniques, which add complexity to the problem, as surgeons do not have the opportunity to directly touch, feel or visualize the organs. In a collaboration between The City College of New York (CCNY) bioengineering design team and Memorial Sloan-Kettering Cancer Center (MSKCC) surgeons, we have successfully designed, constructed and tested a novel wireless, handheld intraoperative oximetry (WiPOX) device, which provides real-time, accurate, and convenient intraoperative monitoring of the tissue oxygenation ensuring tissue viability thereby improving surgical outcomes, decreasing mortality, patient hospitalization and the associated costs. In this R03 proposal, based on the feedback from the ongoing clinical trial, we will enhance device performance and accuracy through two further innovations: incorporation of onboard pressure sensors to allow reliable tissue contact and enhancement of S/N through wireless integration with a systemic pulse oximeter. A pipeline for preclinical and clinical testing is in place. These innovative modifications are crucial for surgeons to take the next step of this device utility - to modify the surgical procedure based on tissue oxygenation.

描述（由申请人提供）：组织缺血是伤口开裂或吻合式泄漏的主要原因，导致显着的发病率和死亡率，并以15至25％的速度发生。尽管在医院期间，通过手指上的脉搏血氧仪测量了通过手指上的脉搏血氧仪的测量，但在手术室中复杂的手术切除和重建后，没有可用于测量组织氧合的设备或方法。越来越多的手术程序是通过微创技术进行的，这会增加问题的复杂性，因为外科医生没有机会直接接触，感觉或可视化器官。在纽约城市学院（CCNY）生物工程设计团队与纪念斯隆 - 凯特（Sloan-Kettering）癌症中心（MSKCC）外科医生之间的合作中，我们已经成功设计，构建和测试了一种新型的无线手持式手持式血氧血通（WIPOX）设备，从而提供了实时，准确的，方便的式式术中，可通过实时，便捷的内部范围进行组织，并通过术中进行渗透性，并进行式内部组织，以实现内部的组织，并进行组织的组织，并进行组织的组织，并进行术中的组织，并进行组织的组织，并进行组织的内部组织，以下范结果，死亡率降低，患者住院和相关费用。在此R03提案中，基于正在进行的临床试验的反馈，我们将通过两项进一步的创新来提高设备性能和准确性：掺入机载压力传感器，以允许通过与系统性脉搏血氧仪的无线整合通过无线整合来实现可靠的组织接触和增强。临床前和临床测试的管道已经到位。这些创新的修饰对于外科医生采取该设备实用程序的下一步至关重要 - 根据组织氧合修改手术程序。