kHz frequency Spinal Cord Stimulation: Novel Temperature-Based Mechanisms of Action

kHz 频率脊髓刺激:基于温度的新型作用机制

基本信息

  • 批准号:
    10709773
  • 负责人:
  • 金额:
    $ 35.07万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-05-01 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

Project(Summary(/(Abstract! There is a need to understand the mechanisms of neural stimulation technologies (RFA-NS-18-018). The impact of such research increases with both the clinical relevance of a neuromodulation technology and the extent mechanisms are unknown. Spinal Cord Stimulation at kHz frequencies (kHz SCS) has undergone a meteoric clinical and market rise, in the absence of an accepted mechanistic hypothesis. The most peculiar feature of kHz SCS mechanistically is that rapid biphasic stimulation undermines traditional mechanisms of electrical stimulation. But, we note this same feature of rapid pulsing results in high stimulation power leading to our hypothesis that kHz SCS increases tissue temperature. Our proposal that a clinically-established implanted electrical stimulation device would unexpectantly function by joule heating is disruptive and innovative and so requires, as the first step, to establish the degree of temperature increase during kHz SCS. To this end, our research plan develops state-of-the-art tools for multi-physics bioheat modeling (Aim 1), multi-compartment 3D- lattice phantom verification (Aim 2), and validation in a swine model (Aim 3) to methodically test the hypothesis that kHz SCS produces a 0.5-2 oC temperature rise. The multi-physics model (Aim 1) will be state-of-the-at in anatomical resolution, internal lead architecture, and the first to couple joule heat, heat conduction and convection (CSF flow), metabolism, and blood flow perfusion. The heat phantom (Aim 2) will be the first for spinal cord stimulation based on novel 3D-lattice printed compartments. The swine model (Aim 3) is selected for anatomical similarities to the human spinal cord and vertebral canal, and will include a custom fabricated combination lead/sensor array for in vivo temperature mapping. The most peculiar clinical feature of kHz SCS is lack of paresthesia, associated with conventional SCS. We will develop a dorsal horn network model of heating- based analgesia (Aim 4) by integrating experimentally validated temperature increases, pain processing network dynamics, and membrane sensitivity to temperature (Q10). We hypothesize a 0.5-2 0C temperature rise generates pain relief through the same final MoA as conventional SCS (gate-control) but without pacing associated paresthesia. RFA responsive, this “computational model incorporates cellular heterogeneity”, specifically electrophysiological data on of excitatory vs inhibitory superficial dorsal horn interneurons, including differential responses to heating. While device design, disease models, and clinical trials are explicitly outside RFA scope, establishing a novel MoA and state-of-the-art tools developed in each Aim implicitly drive and underpin such developments. Directly RFA responsive, we “improve understanding of the neurobiological underpinnings of existing methods and lay the foundation for the next generation technologies by developing models (Aim 1, 4), systems (Aim 2), and procedures (Aim 3) to guide the design of better neuromodulation tools”. Indeed, because the heating MoA is fundamentally innovative, new tools are needed.
项目总结(/(文摘!

项目成果

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MAROM BIKSON其他文献

MAROM BIKSON的其他文献

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{{ truncateString('MAROM BIKSON', 18)}}的其他基金

Open-source computational modeling of Spinal Cord Stimulation (SCS) to enhance dissemination of 1R01NS112996
脊髓刺激 (SCS) 的开源计算模型可增强 1R01NS112996 的传播
  • 批准号:
    10413556
  • 财政年份:
    2021
  • 资助金额:
    $ 35.07万
  • 项目类别:
"Bridges to the Baccalaureate Research Training Program at LaGuardia Community College"
“通往拉瓜迪亚社区学院学士学位研究培训计划的桥梁”
  • 批准号:
    10462520
  • 财政年份:
    2020
  • 资助金额:
    $ 35.07万
  • 项目类别:
"Bridges to the Baccalaureate Research Training Program at LaGuardia Community College"
“通往拉瓜迪亚社区学院学士学位研究培训计划的桥梁”
  • 批准号:
    10689071
  • 财政年份:
    2020
  • 资助金额:
    $ 35.07万
  • 项目类别:
"Bridges to the Baccalaureate Research Training Program at LaGuardia Community College"
“通往拉瓜迪亚社区学院学士学位研究培训计划的桥梁”
  • 批准号:
    10024978
  • 财政年份:
    2020
  • 资助金额:
    $ 35.07万
  • 项目类别:
"Bridges to the Baccalaureate Research Training Program at LaGuardia Community College"
“通往拉瓜迪亚社区学院学士学位研究培训计划的桥梁”
  • 批准号:
    10220083
  • 财政年份:
    2020
  • 资助金额:
    $ 35.07万
  • 项目类别:
The coupled vascular hypothesis for transcranial direct current stimulation (tDCS)
经颅直流电刺激 (tDCS) 的耦合血管假说
  • 批准号:
    9891113
  • 财政年份:
    2017
  • 资助金额:
    $ 35.07万
  • 项目类别:
A tool-box to control and enhance tDCS spatial precision
控制和增强 tDCS 空间精度的工具箱
  • 批准号:
    9229408
  • 财政年份:
    2016
  • 资助金额:
    $ 35.07万
  • 项目类别:
A tool-box to control and enhance tDCS spatial precision
控制和增强 tDCS 空间精度的工具箱
  • 批准号:
    9357699
  • 财政年份:
    2016
  • 资助金额:
    $ 35.07万
  • 项目类别:
Modulation of blood-brain-barrier (BBB) permeability by tDCS relevant electric fi
通过 tDCS 相关电刺激调节血脑屏障 (BBB) 通透性
  • 批准号:
    8702690
  • 财政年份:
    2014
  • 资助金额:
    $ 35.07万
  • 项目类别:
Wireless Pulse Oximetry (WiPOX) for Diagnosing Intra-Operative Ischemia
用于诊断术中缺血的无线脉搏血氧仪 (WiPOX)
  • 批准号:
    8702683
  • 财政年份:
    2014
  • 资助金额:
    $ 35.07万
  • 项目类别:

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脊髓刺激恢复咳嗽的多中心临床试验
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用于慢性疼痛治疗的自动化三维脊柱导航系统
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