Claude D. Pepper Older Americans Independence Center

克劳德·D·佩珀美国老年人独立中心

• 批准号: 8693144
• 负责人: Marco Pahor
• 金额: $ 4.59万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8693144
• 关键词: Acute; Address; Adherence; Aging; American; Animals; Apoptosis; Area; Attention; Autophagocytosis; Basic Science; Behavior Therapy; Behavioral; Behavioral Sciences; Biological; Biological Markers; Biostatistics Core; Caloric Restriction; Chronic; Clinical; Clinical Research; Clinical Sciences; Coronary heart disease; Degenerative polyarthritis; Diabetes Mellitus; Diet; Dietary Intervention; Discipline; Disease; Elderly; Energy Metabolism; Environment; Epidemiology; Event; Evidence based practice; Exercise; Florida; Funding; Geriatrics; Goals; Heart failure; Hip Fractures; Impaired cognition; Inflammation; Intervention; Intervention Studies; Investigation; Knowledge; Lead; Leadership; Metabolism; Mission; Mitochondria; Modeling; Molecular Biology; Muscle; Obesity; Oxidative Stress; Pathway interactions; Physical Function; Pilot Projects; Prevention; Prevention therapy; Process; Public Health; Request for Applications; Research; Research Infrastructure; Research Personnel; Risk Factors; Role; Services; Skeletal Muscle; Stroke; Testing; Training; Translating; Translational Research; United States National Institutes of Health; Universities; age related; career development; data management; disability; effective intervention; experience; functional decline; interdisciplinary approach; loss of function; multidisciplinary; muscle form; muscle strength; novel strategies; preclinical study; prevent; programs; psychosocial; research and development; sarcopenia; skills; success

The mission of the University of Florida Older Americans Independence Center (OAIC) is to assess the risk factors of physical disability in older adults, develop and test effective prevention therapies, and train new investigators in research on aging and disability, while developing their leadership qualities. Our strategy is to attract studies and investigators from diverse behavioral, clinical, and basic science disciplines towards research on aging that is focused on a common research theme, and this, in turn, allows us to accomplish our mission. The theme, "sarcopenia and prevention of disability", is pursued using an interdisciplinary approach that traverses the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, and epidemiology. This research theme addresses the general goal of the OAIC program, namely, to increase scientific knowledge that leads to better ways to maintain or restore independence of older persons. Our research objectives are to (1) assess, using translational research (between basic and clinical disciplines) multiple factors such as biological, co-morbid, psychosocial, and behavioral that contribute to sarcopenia, physical function decline, and progression to disability and (2) develop and reliably test in clinical and pre-clinical studies interventions that target sarcopenia, in order to prevent, delay or recover the age-related declines in physical function and the progression to disability. To address these objectives the proposed OAIC includes the following integrated cores, which support investigators. Junior Scholars, infrastructure, and services: the Leadership and Administrative Core, the Research Career Development Core, the Pilot / Exploratory Studies Core, the Clinical Translational Research Core, the Metabolism and Biomarkers Core, the Biostatistics and Data Management Core, and the Recruitment, Adherence and Retention Core. We train Junior Scholars and support external studies, research development projects, and pilot/exploratory studies. A major strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects and investigators that address one common research theme to be explored through the whole spectrum of biomedical investigation.

佛罗里达大学美国老年人独立中心 (OAIC) 的使命是评估老年人身体残疾的风险因素，开发和测试有效的预防疗法，培训老龄化和残疾研究的新研究人员，同时培养他们的领导素质。我们的策略是吸引来自不同行为、临床和基础科学学科的研究和调查人员进行针对共同研究主题的衰老研究，这反过来又使我们能够完成我们的使命。主题“肌肉减少症和残疾预防”采用跨学科方法，涵盖整个生物医学研究领域，包括分子生物学、动物研究、临床研究、行为科学和流行病学。该研究主题涉及 OAIC 计划的总体目标，即增加科学知识，从而找到更好的方法来维持或恢复老年人的独立性。我们的研究目标是（1）利用转化研究（基础学科和临床学科之间）评估导致肌肉减少症、身体功能下降和残疾进展的生物学、共病、社会心理和行为等多种因素，以及（2）在针对肌肉减少症的临床和临床前研究中开发并可靠地测试干预措施，以预防、延迟或恢复与年龄相关的身体功能下降和进展 至残疾。为了实现这些目标，拟议的 OAIC 包括以下集成核心，为研究人员提供支持。初级学者、基础设施和服务：领导和行政核心、研究职业发展核心、试点/探索性研究核心、临床转化研究核心、代谢和生物标志物核心、生物统计和数据管理核心以及招募、依从性和保留核心。我们培训初级学者并支持外部研究、研究开发项目和试点/探索性研究。拟议的 OAIC 的一个主要优势是跨学科核心、项目和研究人员的协调行动，这些核心、项目和研究人员致力于通过整个生物医学研究探索一个共同的研究主题。