University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)

项目摘要 佛罗里达大学老年美国人独立中心（OAIC）的使命有两个方面：1）优化 通过跨学科方法，提高老年人的身体机能和行动能力; 2）培训新的 研究人员在老龄化和残疾研究，同时发展他们的领导素质。我们的目标是提高 晚年健康和独立，特别注重流动性。为了完成我们的使命，我们的战略是 吸引来自不同行为、临床、基础和技术科学的研究和创造性调查人员 具有共同研究重点的学科：“行动能力和残疾预防”。穿越了整个 生物医学研究，包括分子生物学，动物研究，临床研究，行为科学， 流行病学和工程，我们的研究工作解决了OAIC的总体目标：增加科学 知识，导致更好的方法来保持或恢复老年人的独立性。我们的研究目标 是：1）评估，使用转化研究（不同学科之间），生物，共病， 导致身体功能下降、丧失活动能力的心理、行为和其他因素，以及 向残疾发展; 2）在临床和临床前研究中开发并可靠地测试干预措施， 目标是防止、延迟或恢复与年龄相关的身体功能下降。我们的教育目标 是培养未来衰老临床转化研究的领导者。为了实现这些目标，拟议的OAIC 培训初级学者，并支持调查人员，资源，服务，外部研究，发展项目， 以及通过七个综合核心进行的试点/探索性研究： ·领导和行政核心; ·研究教育核心; ·试点/探索性研究核心; ·临床研究核心; ·代谢和转化科学核心; ·生物统计学核心;以及 ·数据科学与应用技术核心。 拟议中的OAIC的一个相关优势是跨学科核心、项目和 研究人员谁解决一个共同的研究重点，跨越整个频谱的生物医学调查。

PROJECT SUMMARY The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons' physical performance and mobility through interdisciplinary approaches; and 2) to train new investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus: “mobility and prevention of disability.” Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, and engineering, our research effort addresses the OAIC's general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using translational research (among diverse disciplines), the biological, co-morbid, psychosocial, behavioral, and other factors that contribute to physical function decline, loss of mobility, and progression toward disability; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Junior Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: • Leadership and Administrative Core; • Research Education Core; • Pilot/Exploratory Studies Core; • Clinical Research Core; • Metabolism and Translational Science Core; • Biostatistics Core; and • Data Science and Applied Technology Core. A relevant strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.