Claude D. Pepper Older Americans Independence Center (OAIC)

克劳德·D·佩珀美国老年人独立中心 (OAIC)

• 批准号: 7678855
• 负责人: Marco Pahor
• 金额: $ 14.65万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7678855
• 关键词: Acute; Address; Age; Aging; American; Animals; Apoptosis; Area; Arts; Basic Science; Behavior Therapy; Behavioral; Behavioral Sciences; Biological; Biological Markers; Biological Preservation; Biomechanics; Biostatistics Core; Caloric Restriction; Chronic; Clinical; Clinical Research; Condition; Coronary; Coronary heart disease; Degenerative polyarthritis; Development; Diabetes Mellitus; Discipline; Disease; Elderly; Energy Metabolism; Environment; Epidemiology; Equilibrium; Event; Exercise; Florida; Funding; Genetic; Genomics; Geriatrics; Goals; Heart; Heart failure; Hip Fractures; Impaired cognition; Inflammation; Institutes; Intervention; Investigation; Knowledge; Lead; Leadership; Lung diseases; Mediating; Mission; Mitochondria; Modeling; Molecular Biology; Muscle; Muscle function; Obesity; Organ; Oxidative Stress; Pathway interactions; Persons; Physical Function; Pilot Projects; Prevention; Process; Public Health; Recovery; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Risk Factors; Role; Services; Severities; Skeletal Muscle; Skeletal system; Stroke; Testing; Training; Translating; Translational Research; Universities; age related; career; data management; disability; disabling disease; experience; improved; interdisciplinary approach; loss of function; multidisciplinary; muscle strength; novel; novel strategies; post stroke; pre-clinical; pre-clinical research; preclinical study; prevent; programs; psychosocial; research and development; sarcopenia; skills

The mission of the University of Florida Older Americans Independence Center (OAIC) is to assess the risk factors of physical disability in older adults, develop and test effective prevention and rehabilitation therapies, and train new investigators in research on aging and disability, while developing their leadership qualities. Our strategy is to attract studies and investigators from diverse behavioral, clinical, and basic science disciplines towards research on aging that is focused on a common research theme, and this, in turn, will allow us to accomplish our mission. The theme, "sarcopenia, prevention and rehabilitation of disability", will be pursued using an interdisciplinary approach that traverses the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, and epidemiology. This research theme addresses the general goal of the OAIC program, namely, to increase scientific knowledge that will lead to better ways to maintain or restore independence of older persons. Our research objectives are to (1) assess, using translational research (between basic and clinical disciplines) multiple factors such as biological, genetic, co-morbid, psychosocial, and behavioral that contribute to sarcopenia, physical function decline, and progression to disability and (2) develop and reliably test in clinical and preclinical studies interventions that target sarcopenia, in order to prevent, delay or recover the age-related declines in physical function and the progression to disability. To address these objectives the proposed OAIC will include the following integrated cores, which will support investigators, Junior Scholars, infrastructure, and services: the Leadership and Administrative Core, the Research Career Development Core, the Pilot / Exploratory Studies Core, the Clinical Research Core, the Preclinical Research Core, the Biostatistics and Data Management Core, the Recruitment Core, and the Genomics and Biomarkers Core. During the first year we will train nine Junior Scholars and support seven external studies, three research development projects, two pilot studies, one exploratory study and nine small pilot/exploratory studies. A major strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects and investigators that address one common research theme to be explored through the whole spectrum of biomedical investigation.

佛罗里达大学老年美国人独立中心的使命是评估风险 老年人身体残疾的因素，开发和测试有效的预防和康复疗法， 培训新的老龄化和残疾研究人员，同时培养他们的领导素质。 我们的战略是吸引来自不同行为、临床和基础科学领域的研究和调查人员 学科转向老龄化研究，重点关注一个共同的研究主题，而这反过来又将 让我们完成使命主题是“肌肉减少症，预防和残疾康复”， 采用跨学科的方法，贯穿整个生物医学研究领域， 包括分子生物学、动物研究、临床研究、行为科学和流行病学。这 研究主题涉及OAIC计划的总体目标，即增加科学知识 这将导致更好地保持或恢复老年人的独立性。我们的研究目标 是（1）评估，使用转化研究（基础和临床学科之间）多个因素，如 作为生物的，遗传的，共病的，心理社会的，和行为的，有助于肌肉减少症，身体 功能下降和残疾进展，以及（2）在临床和临床前开发和可靠测试 研究针对肌肉减少症的干预措施，以预防，延迟或恢复与年龄相关的下降， 身体功能和残疾的进展。为了实现这些目标，拟议的审计和调查办公室将 包括以下综合核心，这将支持研究人员，初级学者，基础设施， 服务：领导和行政核心，研究职业发展核心，试点/ 探索性研究核心、临床研究核心、临床前研究核心、生物统计学和 数据管理核心，招募核心，基因组学和生物标志物核心。在第一 每年我们将培训9名初级学者，并支持7个外部研究，3个研究发展 这些项目包括两项试点研究、一项探索性研究和九项小型试点/探索性研究。的一个主要优势 拟议的OAIC是跨学科核心、项目和研究人员的协调行动， 解决一个共同的研究主题，通过整个生物医学领域进行探索 调查