Project 4

项目4

基本信息

  • 批准号:
    8744320
  • 负责人:
  • 金额:
    $ 64.73万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-01-01 至 2016-12-31
  • 项目状态:
    已结题

项目摘要

Project 4 has been a leader in revealing the myriad roles played by microRNAs in human cancer. We will build upon this foundation with an increased biological focus on breast cancer. We will isolate the six, well defined mammary epithelial cell types from normal virgin and parous female mice and define their miRNA and mRNA expression profiles. In so doing, we hope to better define the mammary stem cell (MaSC) and gain an appreciation for the pathways that maintain its self-renewal. This will include a definition of miRNAs and miRNA targets that are important in the MaSC. Using normal cells as a reference point, we will work to understand the relafionship between mammary tumor initiating cells and normal mammary stem cells. In part, we aim to test the relevance of tumor initiating populations, which thus far have only been detected in transplantation studies, to breast cancer in in vivo models of basal tumorigenesis. We hope to identify pathways that determine tumor initiating potential and to relate these to self-renewal pathways used by mammary stem cells. We appreciate that both normal and tumor cells function in context, and we will therefore strive to understand how the in vivo niche supports MaSC self-renewal. Similarly, we will ask whether tumor initiating cells occupy a niche or whether their special status is a cell autonomous property. With the realization that it is usually metastatic disease that kills patients, we will also probe the niches occupied by disseminated tumor cells, which can lie dormant for decades following initial treatment before they progress to frank metastases. Using a series of highly innovative strategies, including molecular profiling, RNAi-based genetics, and sophisticated imaging a whole, this Project takes a comprehensive approach to understanding the roles of miRNAs in breast cancer.
Project 4在揭示microrna在人类癌症中扮演的无数角色方面一直处于领先地位。我们将

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Gregory J Hannon其他文献

Free energy lights the path toward more effective RNAi
自由能照亮了通向更有效的 RNAi 的道路
  • DOI:
    10.1038/ng1203-303
  • 发表时间:
    2003-12-01
  • 期刊:
  • 影响因子:
    29.000
  • 作者:
    Jose M Silva;Ravi Sachidanandam;Gregory J Hannon
  • 通讯作者:
    Gregory J Hannon

Gregory J Hannon的其他文献

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{{ truncateString('Gregory J Hannon', 18)}}的其他基金

An optogenetic toolkit for the interrogation and control of single cells.
用于询问和控制单细胞的光遗传学工具包。
  • 批准号:
    8822629
  • 财政年份:
    2014
  • 资助金额:
    $ 64.73万
  • 项目类别:
Core B
核心B
  • 批准号:
    8744323
  • 财政年份:
    2013
  • 资助金额:
    $ 64.73万
  • 项目类别:
Core A
核心A
  • 批准号:
    8744322
  • 财政年份:
    2013
  • 资助金额:
    $ 64.73万
  • 项目类别:
Modulation of Gene Expression Through RNAi
通过 RNAi 调节基因表达
  • 批准号:
    8234421
  • 财政年份:
    2012
  • 资助金额:
    $ 64.73万
  • 项目类别:
Administration
行政
  • 批准号:
    8234420
  • 财政年份:
    2012
  • 资助金额:
    $ 64.73万
  • 项目类别:
Acquisition of a high-throughput compute cluster for biological data analysis
获取用于生物数据分析的高通量计算集群
  • 批准号:
    8247532
  • 财政年份:
    2012
  • 资助金额:
    $ 64.73万
  • 项目类别:
microRNAs in Human Cancer
人类癌症中的 microRNA
  • 批准号:
    8234414
  • 财政年份:
    2012
  • 资助金额:
    $ 64.73万
  • 项目类别:
A ROLE FOR THE P-BODY COMPONENT GW182 IN MICRORNA FUNCTION
P 体成分 GW182 在 MICRORNA 功能中的作用
  • 批准号:
    8171361
  • 财政年份:
    2010
  • 资助金额:
    $ 64.73万
  • 项目类别:
Cold Spring Harbor Laboratory Cancer Research Center
冷泉港实验室癌症研究中心
  • 批准号:
    7910927
  • 财政年份:
    2009
  • 资助金额:
    $ 64.73万
  • 项目类别:
Administration
行政
  • 批准号:
    7225422
  • 财政年份:
    2007
  • 资助金额:
    $ 64.73万
  • 项目类别:

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