Cold Spring Harbor Laboratory Cancer Research Center

冷泉港实验室癌症研究中心

• 批准号: 7910927
• 负责人: Gregory J Hannon
• 金额: $ 9.93万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7910927
• 关键词: Cold; Spring; Harbor; Laboratory; Cancer

DESCRIPTION (provided by applicant): The Program applies a combination of biochemistry, cell biology, genetics and mouse models of human cancer with a unified goal of revealing key tumorigenic pathways. The success of targeted therapeutics continues to reinforce the view that understanding the biology of the cancer cell is the key to treating this disease. Throughout its 35 year history, this Program has focused on translating lessons from DNA tumor viruses into an understanding of both normal cellular and tumor biology. This remains a focus of the Program; however, as the view has shifted from viral to cellular proteins, so is the emphasis evolving from the cancer cell to a broader consideration of the tumor as a tissue. This Program is composed of six highly integrated and mutually supporting Projects and four Cores. The Program is unified buy several themes which run throughout its components. First is the conviction that DNA tumor viruses have been driven by evolution to target the minimal set of fundamental cellular networks that hold the keys to tumorigenic growth. By moving downstream from the viral proteins themselves to their closest cellular counterparts, may projects within the program strive to understand how alterations in c-Myc promote transformation in different cellular and tissue contexts. The Program is also unified in the study of a new class of RNA regulatory molecules, the microRNAs, that act as oncogenes. The Program also exploits these as experimental tools to study gene function. Finally, the Program is cast in the context of sophisticated cancer models that use engineered stem and progenitor cells to rapidly reconstitute organ systems with nearly any desired genetic alteration. The findings from this Program have the potential both to inform the effective application of current therapies and to identify proteins and networks that may become targets for the development of new therapeutic agents.

描述（由申请人提供）：该项目将生物化学、细胞生物学、遗传学和人类癌症小鼠模型相结合，以揭示关键的致瘤途径为统一目标。靶向治疗的成功继续强化了这样一种观点，即了解癌细胞的生物学是治疗这种疾病的关键。在其35年的历史中，该项目一直致力于将DNA肿瘤病毒的经验教训转化为对正常细胞和肿瘤生物学的理解。这仍然是该方案的一个重点；然而，随着观点从病毒转移到细胞蛋白，重点也从癌细胞进化到将肿瘤作为一个组织进行更广泛的考虑。该计划由六个高度整合和相互支持的项目和四个核心组成。该计划是统一的几个主题，贯穿其组成部分。首先，人们确信DNA肿瘤病毒是在进化的驱动下，以最小的基本细胞网络为目标，而这些网络是致瘤性生长的关键。通过从病毒蛋白本身向下游移动到最接近的细胞对应物，该计划中的许多项目努力了解c-Myc的改变如何促进不同细胞和组织环境下的转化。该计划还统一研究一类新的RNA调控分子，即作为致癌基因的microrna。该计划还利用这些作为研究基因功能的实验工具。最后，该计划是在复杂的癌症模型的背景下进行的，这些模型使用工程干细胞和祖细胞来快速重建几乎任何期望的遗传改变的器官系统。该项目的研究结果有可能为当前治疗方法的有效应用提供信息，并确定可能成为新治疗药物开发目标的蛋白质和网络。