2014 Ligand Recognition and Molecular Gating Gordon Research Conference

2014年配体识别与分子门控戈登研究会议

• 批准号: 8647301
• 负责人: Crina M Nimigean
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8647301
• 关键词: Address; Area; Attention; Bacterial Drug Resistance; Beryllium; Binding Proteins; Cardiovascular Diseases; Collaborations; Communities; Computer Simulation; Cystic Fibrosis; Data; Development; Disease; Electrophysiology (science); Employee Strikes; Epilepsy; Faculty; Financial Support; Funding; Future; G-Protein-Coupled Receptors; Goals; Health; Human; Hypertension; Integral Membrane Protein; Ion Channel; Ions; Knowledge; Lead; Ligands; Malabsorption Syndromes; Malignant Neoplasms; Membrane; Membrane Proteins; Membrane Structure and Function; Membrane Transport Proteins; Mental Depression; Methods; Mitochondria; Molecular; Molecular Genetics; Nervous system structure; Neurodegenerative Disorders; Neurotransmitters; Participant; Pharmacologic Substance; Postdoctoral Fellow; Process; Protein Binding; Proteins; Publishing; Recommendation; Research; Research Personnel; Resolution; Role; Schedule; Science; Scientist; Selection Criteria; Signal Transduction; Stretching; Structure; Techniques; Technology; Therapeutic Agents; Thinking; Time; Travel; Vision; Walking; Work; abstracting; base; catalyst; cohort; design; distraction; graduate student; improved; meetings; method development; molecular recognition; multidisciplinary; nervous system disorder; novel therapeutics; posters; programs; public health relevance; receptor; research and development; small molecule; solute; structural biology; success; symposium; transmission process

DESCRIPTION (provided by applicant): The Gordon Research Conference on Ligand Recognition and Molecular Gating will be held from March 23 to March 28, 2014, in Ventura, CA. The conference aims to share the latest knowledge on the functional mechanisms of ion channels; G-protein coupled receptors, and solute transporters. Specifically, the goal of the conference is to increase our understanding of how integral membrane proteins bind or recognize ligands (ions, small molecules, proteins), and how binding elicits conformational changes that lead to transport of the ligands across the membrane, the gating of channels, or the transmission of signals. There will be an emphasis on combining high-resolution structural data with functional and dynamical information to understand mechanisms. The conference is timely because new high-resolution structures of membrane proteins are solved at increasingly rapid pace. In addition, new methods to study the dynamics of the receptors, channels and transporters are being developed and transform the way we understand functional mechanisms. The fields covered in this conference are highly related to human health: channels, transporters and GPCRs are the most fundamental molecular substrates of cellular signaling in the nervous system, among a host of other processes. Understanding the fundamental mechanisms of these proteins will lead to better understanding of normal function, of diseases like epilepsy, hypertension, malabsorption syndromes, cystic fibrosis, and to development of new and improved therapeutic agents. The conference brings together scientists who do not consistently meet because they work on three different classes of membrane proteins. However, they benefit tremendously from interacting because the proteins share common mechanistic principles. The program will have about 40 speakers, well-established leaders in the field of membrane protein research and method development as well as promising young investigators. Nine sessions will address structure, dynamics and mechanism of membrane transporters, ion channels, GPCRs, and specific mitochondrial and bacterial functions. The Gordon Research Conference on Ligand Recognition and Molecular Gating will stimulate advances in this area of membrane protein research by bringing together some of the foremost scientists in this community to present and compare results, discuss new ideas, and establish collaborations.

描述（由申请人提供）：配体识别和分子门控的戈登研究会议将于2014年3月23日至3月28日在加利福尼亚州文图拉举行。会议旨在分享离子通道功能机制的最新知识; G蛋白偶联受体和溶质转运蛋白。具体来说，会议的目标是增加我们对膜蛋白如何结合或识别配体（离子，小分子，蛋白质）的理解，以及如何结合导致配体跨膜运输，通道门控或信号传输的构象变化。将重点放在结合高分辨率结构数据与功能和动力学信息，以了解机制。这次会议是及时的，因为膜蛋白的新的高分辨率结构正在以越来越快的速度解决。此外，正在开发研究受体，通道和转运蛋白动力学的新方法，并改变我们理解功能机制的方式。本次会议涵盖的领域与人类健康高度相关：通道，转运蛋白和GPCR是神经系统中细胞信号传导的最基本分子底物，以及许多其他过程。了解这些蛋白质的基本机制将导致更好地了解正常功能，疾病如癫痫，高血压，吸收不良综合征，囊性纤维化，并开发新的和改进的治疗药物。这次会议汇集了科学家谁不经常见面，因为他们对三种不同类型的膜蛋白的工作。然而，它们从相互作用中受益匪浅，因为蛋白质具有共同的机械原理。该计划将有大约40名演讲者，在膜蛋白研究和方法开发领域的知名领导者以及有前途的年轻研究人员。九次会议将讨论膜转运蛋白，离子通道，GPCR的结构，动力学和机制，以及特定的线粒体和细菌功能。戈登研究会议配体识别和分子门控将刺激膜蛋白研究的这一领域的进展，汇集了一些最重要的科学家在这个社区提出和比较结果，讨论新的想法，并建立合作。