2014 Ligand Recognition and Molecular Gating Gordon Research Conference

2014年配体识别与分子门控戈登研究会议

• 批准号: 8647301
• 负责人: Crina M Nimigean
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8647301
• 关键词: Address; Area; Attention; Bacterial Drug Resistance; Beryllium; Binding Proteins; Cardiovascular Diseases; Collaborations; Communities; Computer Simulation; Cystic Fibrosis; Data; Development; Disease; Electrophysiology (science); Employee Strikes; Epilepsy; Faculty; Financial Support; Funding; Future; G-Protein-Coupled Receptors; Goals; Health; Human; Hypertension; Integral Membrane Protein; Ion Channel; Ions; Knowledge; Lead; Ligands; Malabsorption Syndromes; Malignant Neoplasms; Membrane; Membrane Proteins; Membrane Structure and Function; Membrane Transport Proteins; Mental Depression; Methods; Mitochondria; Molecular; Molecular Genetics; Nervous system structure; Neurodegenerative Disorders; Neurotransmitters; Participant; Pharmacologic Substance; Postdoctoral Fellow; Process; Protein Binding; Proteins; Publishing; Recommendation; Research; Research Personnel; Resolution; Role; Schedule; Science; Scientist; Selection Criteria; Signal Transduction; Stretching; Structure; Techniques; Technology; Therapeutic Agents; Thinking; Time; Travel; Vision; Walking; Work; abstracting; base; catalyst; cohort; design; distraction; graduate student; improved; meetings; method development; molecular recognition; multidisciplinary; nervous system disorder; novel therapeutics; posters; programs; public health relevance; receptor; research and development; small molecule; solute; structural biology; success; symposium; transmission process

DESCRIPTION (provided by applicant): The Gordon Research Conference on Ligand Recognition and Molecular Gating will be held from March 23 to March 28, 2014, in Ventura, CA. The conference aims to share the latest knowledge on the functional mechanisms of ion channels; G-protein coupled receptors, and solute transporters. Specifically, the goal of the conference is to increase our understanding of how integral membrane proteins bind or recognize ligands (ions, small molecules, proteins), and how binding elicits conformational changes that lead to transport of the ligands across the membrane, the gating of channels, or the transmission of signals. There will be an emphasis on combining high-resolution structural data with functional and dynamical information to understand mechanisms. The conference is timely because new high-resolution structures of membrane proteins are solved at increasingly rapid pace. In addition, new methods to study the dynamics of the receptors, channels and transporters are being developed and transform the way we understand functional mechanisms. The fields covered in this conference are highly related to human health: channels, transporters and GPCRs are the most fundamental molecular substrates of cellular signaling in the nervous system, among a host of other processes. Understanding the fundamental mechanisms of these proteins will lead to better understanding of normal function, of diseases like epilepsy, hypertension, malabsorption syndromes, cystic fibrosis, and to development of new and improved therapeutic agents. The conference brings together scientists who do not consistently meet because they work on three different classes of membrane proteins. However, they benefit tremendously from interacting because the proteins share common mechanistic principles. The program will have about 40 speakers, well-established leaders in the field of membrane protein research and method development as well as promising young investigators. Nine sessions will address structure, dynamics and mechanism of membrane transporters, ion channels, GPCRs, and specific mitochondrial and bacterial functions. The Gordon Research Conference on Ligand Recognition and Molecular Gating will stimulate advances in this area of membrane protein research by bringing together some of the foremost scientists in this community to present and compare results, discuss new ideas, and establish collaborations.

描述（由申请人提供）：戈登（Gordon）识别和分子门控戈登研究会议将于2014年3月23日至3月28日在加利福尼亚州的文图拉举行。会议旨在分享有关离子渠道功能机制的最新知识； G蛋白偶联受体和溶质转运蛋白。具体而言，会议的目的是提高我们对整合膜蛋白如何结合或识别配体（离子，小分子，蛋白质）的理解，以及结合如何引发构象变化，从而导致配体跨膜的运输，通道的门控或信号传播。将强调将高分辨率结构数据与功能和动态信息相结合以了解机制。会议之所以及时，是因为膜蛋白的新高分辨率结构以日益快速的速度解决。此外，正在开发研究受体，通道和转运蛋白动力学的新方法，并改变我们理解功能机制的方式。本次会议中涵盖的领域与人类健康高度相关：在神经系统中，通道，转运蛋白和GPCR是细胞信号传导最基本的分子底物，在其他许多过程中。了解这些蛋白质的基本机制将使人们更好地了解正常功能，癫痫，高血压，吸收不良综合征，囊性纤维化以及新的和改善的治疗剂等疾病。会议汇集了不始终相遇的科学家，因为他们使用了三种不同类别的膜蛋白。但是，由于蛋白质具有共同的机械原理，因此它们从相互作用中受益匪浅。该计划将有大约40名演讲者，在膜蛋白研究和方法开发领域的公认领导者以及有前途的年轻研究者。九个会话将解决膜转运蛋白，离子通道，GPCR以及特定线粒体和细菌功能的结构，动力学和机制。戈登（Gordon）识别和分子门控的戈登研究会议将通过汇集该社区中一些最重要的科学家来提出和比较结果，讨论新思想并建立合作，从而刺激这一膜蛋白研究领域的进步。