Validation and application of portable particulate device in the UW Twin Registry

便携式颗粒物装置在威斯康星大学双胞胎登记处的验证和应用

• 批准号: 8799735
• 负责人: GLEN E DUNCAN
• 金额: $ 21.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8799735
• 关键词: Address; Adult; Air; Air Pollution; Allergens; Area; Behavior; Behavioral Genetics; Biological; Blood Pressure; Body mass index; Cellular Phone; Characteristics; Chronic Disease; Clinical; Clinical Data; Communities; DNA; Data; Data Analyses; Devices; Diet; Dizygotic Twins; Ecological momentary assessment; Environment; Environmental Exposure; Environmental Health; Environmental Monitoring; Epidemiologic Studies; Exposure to; Feedback; Focus Groups; Future; Genetic; Gold; Health; Height; Human; Hydrocortisone; Hypertension; Individual; Inflammation; Inflammatory; Interleukin-10; Interleukin-6; Laboratory Study; Lead; Life; Life Style; Link; Measures; Methods; Mission; Modeling; Monitor; Monozygotic Twinning; Monozygotic twins; Movement; National Institute of Environmental Health Sciences; Noise; Outcome; Participant; Particulate; Particulate Matter; Pattern; Personal Behavior; Phase; Physical activity; Play; Psychosocial Stress; Questionnaires; Registries; Research; Respiratory physiology; Sampling; Selection Bias; Sensitivity and Specificity; Specimen; Spirometry; Stress; Surveys; System; Technology; Time; Toxic Environmental Substances; Toxicant exposure; Toxin; Translations; Tumor Necrosis Factor-alpha; Twin Multiple Birth; Universities; Update; Validation; Washington; Weight; Work; base; built environment; cost; cytokine; data management; design; field study; gene environment interaction; improved; innovation; insight; instrument; novel; particle; particle counter; programs; repository; sound; tool; usability; waist circumference

DESCRIPTION (provided by applicant): This research addresses the mission of the National Institutes of Environmental Health Sciences by increasing our understanding of how the environment influences human health through validation of a new wearable device that measures multiple environmental toxicants in real-time and space, called the Portable University of Washington Particle Monitor (PUWPM), and application in a genetically informed sample of adult twins from the community-based UW Twin Registry (UWTR). The use of twins is unique in environment-based research because it will allow us to assess the associations between environmental exposures and health outcomes while controlling for genetic and shared environmental (familial) influences that might otherwise introduce selection biases into the choice of living environments that contribute to differential levels of exposures, and thus confound similar studies in unrelated individuals. Furthermore, our innovative methods will allow us to link environmental exposures with accelerometer and GPS-based measures of movement through space. Using GIS, we will capture spatially continuous variables relevant to the built environment at the same scale as the exposures and movement patterns. In the first phase the study (R21 phase), the design-feedback iterative cycle will be used to assess the feasibility and usability of the integrated PUWP monitor to assess multiple aspects of behavior and toxic exposures in 15 pairs of twins. Based on qualitative data obtained from focus groups and quantitative data from usability surveys, we will improve the design and ease of use of the PUWP through 2 or 3 iterative cycles. Concurrently, the validity of the PUWP will be established in these same 15 pairs compared to gold standard methods. In the second phase of the study (R33 phase), we will collect clinical measures including blood pressure, body mass index, waist circumference, and lung function (spirometry), as well as biologic measures including inflammatory cytokines and cortisol in a larger sample of 150 twin pairs. Using these measures, we will first compare associations between clinical/biological outcomes with PM 2.5 measures from the PUWP against their associations with exposure estimates based on ambient air quality models that are standard in the field. Next, we will determine the associations among air pollution, noise, and other environmental exposures from the integrated PUWP system, lifestyle behaviors including physical activity and diet, and psychosocial stress with the various clinical and biologic outcomes. Ultimately, our unique sample and methods will lead to new and important insights linking environmental, behavioral, and genetic aspects of chronic disease.

描述(由申请人提供)：这项研究通过验证一种名为便携式华盛顿大学颗粒监测器(PUWPM)的新型可穿戴设备在实时和空间上测量多种环境毒物，并应用于来自社区的UW双胞胎登记中心(UWTR)的成年双胞胎遗传样本，从而提高了我们对环境如何影响人类健康的理解，从而实现了美国国家环境健康科学研究院的使命。双胞胎的使用在以环境为基础的研究中是独一无二的，因为它将使我们能够评估环境暴露与健康结果之间的关联，同时控制遗传和共享的环境(家族)影响，否则可能会在生活环境的选择中引入选择偏见，从而导致不同水平的暴露，从而在无关的个人中混淆类似的研究。此外，我们的创新方法将使我们能够将环境暴露与加速计和基于GPS的空间移动测量联系起来。利用地理信息系统，我们将在与曝光和运动模式相同的尺度上捕捉与建筑环境相关的空间连续变量。在研究的第一阶段(R21阶段)，将使用设计-反馈迭代周期来评估集成PUWP监测仪的可行性和可用性，以评估15对双胞胎的多方面行为和毒性暴露。根据从焦点小组获得的定性数据和从可用性调查获得的定量数据，我们将通过2到3个迭代周期改进PUWP的设计和易用性。同时，与黄金标准方法相比，PUWP的有效性将在这15对中确定。在研究的第二阶段(R33阶段)，我们将收集包括血压、体重指数、腰围和肺功能(肺活量测定)在内的临床指标，以及包括炎性细胞因子和皮质醇在内的生物指标，对150对双胞胎进行更大规模的样本调查。使用这些指标，我们将首先比较临床/生物结果与PUWP的PM2.5指标之间的关联，以及它们与基于现场标准环境空气质量模型的暴露估计之间的关联。接下来，我们将确定空气污染、噪音和来自综合PUWP系统的其他环境暴露、包括体力活动和饮食在内的生活方式行为以及心理社会压力与各种临床和生物结果之间的关系。最终，我们独特的样本和方法将导致将慢性病的环境、行为和遗传方面联系起来的新的和重要的见解。