TWINStudy of Environment, Lifestyle Behaviors, and Health

双胞胎环境、生活方式行为和健康研究

• 批准号: 8209591
• 负责人: GLEN E DUNCAN
• 金额: $ 55.05万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8209591
• 关键词: Adult; Affect; Attention; Automobiles; Behavior; Behavioral Genetics; Biological; Body mass index; Car Phone; Chronic Disease; Communities; Controlled Environment; DNA; Data; Data Analyses; Data Set; Databases; Devices; Diet; Diet Habits; Dietary intake; Distal; Eating; Eating Behavior; Environment; Exercise; Food; Future; Genes; Genetic; Genetic Predisposition to Disease; Goals; Habits; Health; Health Benefit; Health behavior; Home environment; Individual; Intervention; Knowledge; Lead; Life; Life Style; Link; Location; Measures; Methods; Modeling; Monitor; Monozygotic Twinning; Monozygotic twins; Neighborhoods; Obesity; Overweight; Persons; Physical activity; Play; Population; Randomized; Recreation; Registries; Relative (related person); Research; Research Design; Research Project Grants; Resolution; Restaurants; Risk; Role; Sampling; Selection Bias; Signal Transduction; Solutions; Specificity; Technology; Telephone; Time; Twin Multiple Birth; Universities; Walking; Washington; Weight; Work; barometric pressure; base; behavior influence; behavioral/social science; data management; design; energy balance; energy density; fast food; innovation; insight; nutrition; programs; repository; residence; sedentary; statistics; suburb; tool

DESCRIPTION (provided by applicant): The goal of this research is to determine how the built environment in which individuals live, work, and play in on a daily basis influences their lifestyle behaviors and health. We couple advanced methods in geospatial data management and analysis with cutting-edge technology, the multisensor board (MSB), to gather objective information about the built environment and lifestyle behaviors in real time and space. The MSB is a small wearable device with multiple sensing capabilities, including accelerometry, barometric pressure, and location, connected wirelessly to a WiFi enabled mobile telephone. Outdoor and indoor activities are monitored using GPS and WiFi signals to obtain data with high spatial resolution. The mobile phone has been adapted for use as an automated food intake program. We will use this integrated tool in a study of environmental influences on lifestyle behaviors and health in a community-based sample of adult monozygotic twins who were reared together but now live apart. With these tools and methods, we will create a unique and rich dataset linking rigorous measures of physical activity and eating in real time and space relative to locations in the built environment. This approach will build upon and extend our knowledge by measuring lifestyle behaviors in continuous time and space within and beyond the individual residential locations (neighborhoods) of twins. Using a co-twin control design, we will examine monozygotic pairs who live apart and determine how the home built environment influences levels of both walking and total physical activity, free of genetic and familial influences. Next, we will measure and compare location-based activity and eating episodes in real-time to investigate how often the twins use features of their home built environment that are associated with activity and eating. By measuring how many activity and eating episodes occur in the home built environment versus in distal built environments, including work, transit, and recreation-related settings, we will be able to determine whether proximity to features of the home built environment are associated with their use. Finally, we will measure associations among the built environment, lifestyle behaviors, and body mass index in twins who live apart by linking weight status with physical activity levels and food intake to determine if body mass index is associated with the built environment through these behaviors. Our scientific approach integrates conceptual models from the behavioral and social sciences with biological, computational, and physical measures in a genetically informative research design. This effort lays the critical groundwork to use an existing repository of phenotypic data and biological samples, including DNA, in future research to determine how specific genes interact with the environment to influence behaviors and health. Ultimately, our unique sample and scientific methods will lead to new and important insights linking environmental, behavioral, and genetic aspects of obesity and chronic disease. PUBLIC HEALTH RELEVANCE: The goal of this research project is to determine how people interact with the built environment in which they live, work, and play in on a daily basis. We focus on the built environment because health in a population is a function of macro-level or big picture influences that affect the lives of all people, not just individuals. We measure behaviors such as physical activity and eating habits that are closely linked with energy balance and health under real world conditions using powerful new tools that may be used in the future in commercially available devices such as mobile telephones.

描述（由申请人提供）：本研究的目标是确定个人日常生活、工作和娱乐的建筑环境如何影响他们的生活方式行为和健康。我们将地理空间数据管理和分析的先进方法与多传感器板（MSB）这一尖端技术相结合，以收集有关真实的时间和空间中的建筑环境和生活方式行为的客观信息。MSB是一种小型可穿戴设备，具有多种传感功能，包括加速度计、气压和位置，无线连接到支持WiFi的移动的电话。使用GPS和WiFi信号监测室外和室内活动，以获得高空间分辨率的数据。这部移动的手机已经被改造成一个自动进食程序。我们将使用这个综合工具，在一个以社区为基础的样本的成年同卵双胞胎谁一起长大，但现在分开生活的生活方式行为和健康的环境影响的研究。有了这些工具和方法，我们将创建一个独特而丰富的数据集，将严格的身体活动措施和相对于建筑环境中位置的真实的时间和空间中的饮食联系起来。这种方法将通过测量双胞胎个人居住地点（社区）内外连续时间和空间的生活方式行为来建立和扩展我们的知识。使用双胞胎对照设计，我们将研究分开居住的同卵双胞胎，并确定家庭环境如何影响步行和总体力活动水平，不受遗传和家庭影响。接下来，我们将实时测量和比较基于位置的活动和饮食事件，以调查双胞胎使用与活动和饮食相关的家庭环境特征的频率。通过测量有多少活动和进食事件发生在家庭建筑环境中与远端建筑环境中，包括工作，交通和娱乐相关的设置，我们将能够确定是否接近家庭建筑环境的功能与其使用相关。最后，我们将通过将体重状况与身体活动水平和食物摄入量联系起来，来衡量双胞胎的建筑环境，生活方式行为和体重指数之间的关联，以确定体重指数是否与建筑环境相关。我们的科学方法将行为和社会科学的概念模型与生物，计算和物理措施结合在一起，以遗传信息研究设计。这项工作为在未来的研究中使用现有的表型数据和生物样本（包括DNA）库奠定了关键基础，以确定特定基因如何与环境相互作用，从而影响行为和健康。最终，我们独特的样本和科学方法将带来新的重要见解，将肥胖和慢性病的环境、行为和遗传方面联系起来。 公共卫生关系：该研究项目的目标是确定人们如何与他们日常生活，工作和娱乐的建筑环境互动。我们专注于建筑环境，因为人口的健康是影响所有人而不仅仅是个人生活的宏观或宏观影响的函数。我们使用强大的新工具，在真实的世界条件下测量与能量平衡和健康密切相关的行为，如身体活动和饮食习惯，这些工具可能会在未来用于移动的电话等商用设备。