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Production , purification and preparation of various candidiate vaccines

Production , purification and preparation of various candidiate vaccines
各种候选疫苗的生产、纯化和制备
批准号：
9148975
负责人：
Joseph Shiloach
金额：
$31.38万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9148975
关键词：
BacteriaBiotechnologyBioterrorismCellsConjugate VaccinesDevelopmentMethodsPolysaccharidesPreparationProceduresProductionPublic HealthRotavirus VaccinesSolidSurfaceSuspension substanceSuspensionsVaccine ProductionVaccinesVero CellsVirusVirus DiseasesWorkbaseimproved

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中文摘要
翻译
本实验室继续其评估悬浮细胞生产轮状病毒疫苗的潜力的项目。目前的疫苗生产程序是基于在固体表面上生长的细胞，这是繁琐且工作密集的。从悬浮培养的细胞中生产病毒更简单，但涉及我们目前正在研究的细胞和病毒适应。Vero细胞适于悬浮生长，病毒感染方法正在开发中。关于结合疫苗的倡议，该实验室正在与FDA合作，从不同的细菌中生产多糖，用于结构研究。
英文摘要
The Lab continues its project on evaluating the potential production of rotavirus vaccine form suspension cells. The current vaccine production procedure is based on cells growing on solid surface which is cumbersome and work intensive. Production the virus from cells growing in suspension is simpler but involves cell and virus adaptation which we currently investigating. Vero cells were adapted to grow in suspension and virus infection methods are being developed. Concerning the conjugated vaccines initiative the lab is collaborating with the FDA on production of polysaccharides from different bacteria for structural studies.
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