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Improvement to the Animal Facility HVAC System at the Monell Chemical Senses Center

莫内尔化学感官中心动物设施 HVAC 系统的改进

基本信息

批准号：
8902318
负责人：
DANIELLE Renee REED
金额：
$ 49.78万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-15 至 2018-07-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8902318
关键词：
Accounting Accreditation Affect Age Aging Air American Animal Housing Animal Model Animals Biology Breeding Caring Chemicals Cities Comparative Biology Complement Contracts Deterioration Emergency Situation Engineering Ensure Environment Extravasation Failure Ferrets Funding Goals Guidelines Health Heart Heating Humidity IACUC Institutes Laboratory Animal Medicine Laboratory Animals Lead Licensing Location Maintenance Major Histocompatibility Complex Mechanics Microtus Miniature Swine Mission Mus Paper Parents Particulate Pennsylvania Plumbing Principal Investigator Procedures Publishing Rattus Recovery Reporting Research Research Institute Research Project Grants Role Safety Science Scientist Sensory Services Shrews Side Smell Perception System Taste Buds Taste Perception Temperature Testing Time Training United States United States Department of Agriculture United States National Institutes of Health Universities Update Veterinarians Work animal care animal facility authority building renovation college design and construction exhaust experience human disease improved non-compliance nonhuman primate offspring operation programs square foot sweet taste perception

项目摘要

DESCRIPTION (provided by applicant): The aim of this application is to improve the Animal Facility of the Monell Chemical Senses Center and facilitate its accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). A not-for-profit research institute [501(c)(3)], Monell was founded in 1968 with a unique mission to investigate the basic biology of taste and smell. This institute, originally part of the University of Pennsylvania, is in the heart of the University City Science Center, the largest and oldest urban research center in the United States. Monell's research is supported predominantly by the National Institutes of Health and other governmental agencies, such as the U.S. Department of Agriculture. The annual research conducted at Monell totals $16M. Animals -- mostly mice, rats, and ferrets -- are now used by 12 research programs at Monell and account for nearly $6M research dollars spent annually. Most research now is conducted with mice, but in the past, animal studies have used nonhuman primates, meadow voles, musk shrews, mini-swine, and wild-caught animals housed in the facility. Research projects on taste and smell conducted with animals housed at Monell have resulted in discoveries that have influenced the direction and scope of research programs on taste and smell, nationally and internationally. For instance, the sweet taste receptor was identified in a mouse study at Monell, as was the role of the major histocompatibility complex in parents' ability to identify offspring by smell. Monell is also well known for its work on comparative biology. Monell's current facility of animal care was established in 1971. In 1989 it was gutted and rebuilt, in part with NIH funds. The animal care and use program at Monell is well developed: It has operated successfully for the past 43 years and is licensed by the USDA, with no non-compliant findings. Our goal is to update our ~10,800 square foot Animal Facility and obtain accreditation by AAALAC. To accomplish this goal, we need to replace the air-handling unit that supplies the Animal Facility. This unit functions poorly and is in imminent danger of failing due to its age. Its lack of redundancy makes maintenance difficult, because emergency procedures must often be used to support the animal environment while work is performed on it. The prospect of catastrophic failure grows more likely with each passing month. Although temperature and humidity can usually be maintained within the range required for animal safety, these parameters often deviate too much for optimal research conditions, with unacceptable swings in humidity becoming increasingly common. Moreover, the amount of heat recovery has decreased over time and this deficit has accelerated recently due to deterioration of the system's coils. This problem is very difficult to fix, because the tight location of key parts of the unit makes cleaning and servicing the heat exchange coils almost impossible. There is also an immediate concern that leakage in the discharge side of the exhaust ductwork may lead to air-borne contaminants (particulate material) that could affect the health of our animals and interfere with sensory testing in our research programs. Our plan is to replace the aging primary air-handling system with a new system that features redundancy, ease of maintenance access, significantly improved energy recovery, and corrections to the exhaust system to reduce air-borne particulates. This new system is projected to be at least 20% more energy efficient over the existing unit's peak efficiency (which is no longer realized) and will provide significantly better control over temperature and humidity. Monell has a clear line of authority for managing its Animal Facility. Monell's Director supervises the Director of Facilities Management, who manages the Animal Facility and the program of animal care under the guidance of the Institutional Animal Care and Use Committee (IACUC). She has nearly three decades of experience in this role, has managed several major renovations at Monell over the years, and will be the Project Manager. An expert Building Engineer, who is responsible for electrical, plumbing, and mechanical aspects of the buildings, reports to the Director of Facilitie Management. The Principal Investigator of this application is a scientist with 30 years of experience at Monell, with funded projects that rely heavily on mouse breeding and over 100 published papers on animal models of human disease, who also has served on Monell's IACUC. An experienced American College of Laboratory Animal Medicine board-certified laboratory animal Attending Veterinarian has been guiding Monell's program of animal care and use since 1982, including the original design and construction of the Animal Facility, IACUC responsibilities and functions, animal care operations, veterinary care, training, and compliance. The expert Mechanical Engineer that Monell contracted for this application has project management expertise, has participated in many major renovations of this building, and provided detailed line drawings for this application. He complements the expert and experienced team that Monell has assembled for this essential renovation project. Air-handling renovations described in this proposal will result in necessary and important improvements to Monell's facilities of animal care, thereby ensuring the health and safety of its animals and the quality of chemosensory research on which Monell relies. By replacing the most obsolete part of the Animal Facility, we will ensure that environmental conditions for the animals will be within the AAALAC accreditation guidelines.

描述(由申请人提供)：本申请的目的是改善莫内尔化学感觉中心的动物设施，并促进其通过实验动物护理评估与认可协会(AAALAC)的认证。莫内尔是一家非营利性研究机构[501(C)(3)]，成立于1968年，其独特的使命是研究味觉和气味的基本生物学。该研究所最初是宾夕法尼亚大学的一部分，位于美国最大、最古老的城市研究中心大学城科学中心的中心。莫内尔的研究主要得到了美国国立卫生研究院和其他政府机构的支持，如美国农业部。在莫内尔大学进行的年度研究总额为1600万美元。动物--主要是小鼠、大鼠和雪貂--现在被莫内尔大学的12个研究项目使用，每年花费近600万美元用于研究。现在的大多数研究都是在老鼠身上进行的，但在过去，动物研究使用了非人类灵长类动物、草地田鼠、麝鼠、迷你猪和设施中饲养的野生动物。在Monell饲养的动物身上进行的味觉和嗅觉研究项目导致了一些发现，这些发现影响了国内外味觉和嗅觉研究计划的方向和范围。例如，在Monell的一项小鼠研究中发现了甜味受体，就像主要组织相容性复合体在父母通过气味识别后代的能力中所起的作用一样。莫内尔大学还以其在比较生物学方面的工作而闻名。莫内尔目前的动物护理机构成立于1971年。1989年，它被拆除并重建，部分资金来自美国国立卫生研究院。莫内尔的动物护理和使用项目发展得很好：在过去的43年里，它成功地运作了，并获得了美国农业部的许可，没有发现不符合规定的情况。我们的目标是更新我们约10,800平方英尺的动物设施，并获得AAALAC的认证。为了实现这一目标，我们需要更换为动物设施供应的空气处理单元。这台机器运转不好。由于年代久远，它面临着失败的迫在眉睫的危险。它缺乏冗余性，这使得维护变得困难，因为在对动物环境进行工作时，必须经常使用紧急程序来支持动物环境。灾难性失败的可能性一月比一月大。尽管温度和湿度通常可以保持在动物安全所需的范围内，但这些参数往往偏离太多，无法达到最佳研究条件，湿度的不可接受波动变得越来越常见。此外，热回收的数量随着时间的推移而减少，由于系统盘管的劣化，这种不足最近加速了。这个问题很难解决，因为机组关键部件的紧密位置使得清洗和维修换热盘管几乎是不可能的。还有一个迫在眉睫的问题是，排气管道排放侧的泄漏可能会导致空气中的污染物(颗粒物)，这可能会影响我们动物的健康，并干扰我们研究计划中的感官测试。我们的计划是用一个新的系统取代老化的一次空气处理系统，该系统具有冗余性、易于维护、显著改进的能量回收，并对排气系统进行修正以减少空气中的颗粒物。这一新系统预计将比现有机组的峰值效率(不再实现)至少提高20%的能效，并将显著改善对温度和湿度的控制。Monell在管理其动物设施方面有明确的权力界限。Monell的主任监督设施管理主任，后者在机构动物护理和使用委员会(IACUC)的指导下管理动物设施和动物护理计划。她在这个职位上有近30年的经验，多年来管理过Monell的几次重大翻修，并将担任项目经理。负责建筑物的电气、管道和机械方面的专家建筑工程师向设施管理主任报告。该应用程序的首席研究员是一位在Monell拥有30年经验的科学家，他资助的项目严重依赖于老鼠饲养，并发表了100多篇关于人类疾病动物模型的论文，他也曾在Monell的IACUC工作。自1982年以来，一位经验丰富的美国实验动物医学院董事会认证的实验动物主治医师一直在指导Monell的动物护理和使用计划，包括动物设施的原始设计和建造、IACUC的职责和功能、动物护理操作、兽医护理、培训和合规。Monell为该应用程序签约的专业机械工程师具有项目管理专业知识，参与了该建筑的多次重大翻新，并为该应用程序提供了详细的线路图。他补充了Monell为这个重要的翻修项目组建的专家和经验丰富的团队。本提案中描述的空气处理翻新将对Monell的动物护理设施进行必要和重要的改进，从而确保其动物的健康和安全以及莫内尔所依赖的化学感官研究。通过更换动物设施中最陈旧的部分，我们将确保动物的环境条件符合AAALAC认证指南。