Workshops in Molecular and Cellular Glycoscience

描述（由申请人提供）：修饰所有真核细胞表面的糖蛋白和糖脂的聚糖（碳水化合物）成分，以及由这些细胞产生的分泌糖蛋白，与聚糖结合蛋白相互作用，介导细胞过程，包括免疫细胞的分化、激活和迁移、蛋白质折叠的质量控制和细胞表面蛋白质组成的调节。尽管这些过程很重要，但对聚糖合成调控、聚糖对糖蛋白结构的影响以及细胞对蛋白-聚糖相互作用的功能反应的分子水平描述仍处于起步阶段。这在一定程度上反映了其重要性

DESCRIPTION (provided by applicant): The glycan (carbohydrate) components of the glycoproteins and glycolipids that adorn the surfaces of all eukaryotic cells, as well as the secreted glycoproteins produced by these cells, interact with glycan binding proteins to mediate cellular processes that include differentiation, activation and migration of immune cells, quality control in protein folding, and regulation of protein composition at the cell surface. Despite the importance of these processes, molecular level descriptions of the regulation of glycan synthesis, the influence of glycans on glycoprotein structure, and the functional responses of cells to protein-glycan interactions remain at their infancy. In part this reflects the significant challenges presented by glycan structural diversity and by the complexity of cellular responses to the varied glycan presentations found at diverse biological interfaces. A key to overcoming these challenges is the cooperation of researchers with skills of sufficient diversity to allow the formulation of comprehensive solutions. This proposal requests funding for a series of workshops (two per year), one general meeting, and a networking infrastructure, that will promote the interaction of researchers with these diverse skills in order to solve challenging problems in glycoscience. The communication network and workshop structure proposed here is built on the successful experience of the Consortium for Functional Glycomics (CFG), an entity funded by a "Glue Grant" for the last ten years, and its pool of now more than 500 participating investigators. The proposed workshops will broaden the scope of glycoscience investigations and facilitate the formation of new research teams to address major issues of importance to human health.