Refinement and Expansion of the Palliative Care Research Cooperative Group (PCRC)

姑息治疗研究合作小组 (PCRC) 的完善和扩大

• 批准号: 8926710
• 负责人: JEAN S KUTNER
• 金额: $ 183.94万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-28 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8926710
• 关键词: Address; Applications Grants; Area; Behavior Therapy; Behavioral Research; Caregivers; Caring; Clinical; Clinical Research; Clinical Trials; Communities; Data; Development; Disease; Environment; Epidemiology; Evolution; Funding; Future; Goals; Gold; Grant; Health; Health Services; Information Systems; Institute of Medicine (U.S.); Intention; International; Investments; Knowledge; Letters; Life; Measures; Methodology; Methods; Outcome; Palliative Care; Patients; Phase; Population; Principal Investigator; Procedures; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Priority; Research Support; Research Training; Resources; Risk; Role; Sampling; Science; Site; Staging; Structure; System; Training; Work; advanced disease; behavioral outcome; biobehavior; design; effectiveness research; end of life; evidence base; improved; innovation; interest; patient oriented; research study

DESCRIPTION (provided by applicant): In 2010, the Palliative Care Research Cooperative Group (PCRC) was developed as a national collaborative research network to become the scalable, supportive structure so critically needed for the conduct of high quality clinical trials Work proposed under the current grant will build on the accomplishments achieved during the initial NINR funding for the PCRC (UC4NR012584). The overarching objective of this U24 grant application is to amplify the role of the PCRC as a national resource for efficient conduct of high quality, collaborative, multisite, palliative care and end-of-life (PCEOL) research by leveraging and building upon the prior NINR investment and accomplishments of the PCRC to date. The steps planned for further PCRC development will enable it to: (1) support research and develop expertise in understudied PCEOL areas such as caregiver and bio-behavioral research; (2) facilitate efficient and expeditious conduct of important, cutting-edge studies that require large samples and multiple sites; (3) prepare future researchers to utilize and sustain the enterprise, while continuing to build the PCEOL evidence base, and; (4) describe, quantify, and understand the risks, issues, and impact of life-limiting disease on multiple relevant outcomes including health outcomes for patients and caregivers and bio-behavioral interventions and outcomes. Specifically, we propose to rapidly increase the capacity of the PCRC to develop and conduct a diversified portfolio of high quality research studies that are responsive to key gaps in the scientific knowledge. We will achieve these goals through the following specific aims: (1) develop a national research capacity for collaborative, multisite, PCEOL research in a way that maximizes the quality and efficiency of research and the effectiveness of cooperative groups; and (2) provide integrated support for PCEOL research, specifically, for the conduct, analysis, and dissemination of clinically meaningful, high-quality, efficient, patient-centered, multisite studies. The combined result of achieving these aims will be a highly efficient, adaptive, and standardized system to advance prioritized, innovative, rigorously designed and performed, studies in PCEOL research, with a particular emphasis on clinical trials requiring multiple recruitment sites. RELEVANCE: The Palliative Care Research Cooperative Group (PCRC) addresses national research priorities in palliative care and end-of-life (PCEOL) through enhancing efficient conduct and dissemination of high-quality, collaborative, multisite, PCEOL research. The result of achieving the PCRC aims will be a highly efficient, adaptive, and standardized system to advance prioritized, innovative, rigorously designed and performed PCEOL studies that will ultimately enhance and improve care for people with serious and life limiting illnesses.

描述（由申请人提供）：2010年，姑息治疗研究合作小组（PCRC）是作为国家协作研究网络开发的，成为一个可扩展的，支持性的结构，非常需要在当前赠款中提出的高质量临床试验工作，将基于PCRC最初的NINR资金基础上取得的成就，以实现的成就（UC4NRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRI012584）。该U24赠款申请的总体目标是扩大PCRC作为有效行为的国家资源的作用 质量，协作，多站点，姑息治疗和临终关怀（PCEOL）研究，通过利用和建立迄今为止PCRC的尼尔投资和成就。计划进一步PCRC开发的步骤将使IT：（1）支持研究和发展研究的专业知识，例如护理人员和生物行为研究； （2）促进需要大量样本和多个地点的重要的，最先进的研究； （3）准备未来的研究人员利用和维持企业，同时继续建立PCEOL证据基础，并且； （4）描述，量化和理解生命疾病对多种相关结果的风险，问题和影响，包括患者和护理人员的健康结果以及生物行为的干预措施和结果。具体而言，我们建议迅速提高PCRC发展和进行多样化的高质量研究组合的能力，这些研究对科学知识中的关键差距有反应。我们将通过以下特定目标实现这些目标：（1）以最大化研究质量和效率的方式发展国家协作，多站点，PCEOL研究的国家研究能力； （2）为PCEOL研究提供了综合支持，特别是用于临床上有意义，高质量，高效，以患者为中心的多站点研究的行为，分析和传播。实现这些目标的综合结果将是一个高效，适应性和标准化的系统，以提高优先考虑，创新，严格设计和执行的PCEOL研究研究，并特别强调需要多个招聘场所的临床试验。 相关性：姑息治疗研究合作小组（PCRC）通过增强高效的行为和传播高质量的，协作，多站点，PCEOL研究来解决姑息治疗和临终关怀（PCEOL）的国家研究重点。实现PCRC目标的结果将是一种高效，适应性和标准化的系统，可以提高优先级，创新，严格设计和执行的PCEOL研究，最终将改善和改善严重且限制生命疾病的人的护理。