Refinement and Expansion of the Palliative Care Research Cooperative Group (PCRC)

描述(申请人提供)：2010年，缓和护理研究合作小组(PCRC)被发展为一个全国性的协作研究网络，成为开展高质量临床试验工作所必需的可扩展的支持性结构。目前的拨款建议将建立在为PCRC(UC4NR012584)提供NINR初始资金期间取得的成就基础上。这项U24赠款申请的首要目标是扩大PCRC作为国家资源的作用，通过利用和发展PCRC之前的NINR投资和迄今取得的成就，有效地开展高质量、协作、多地点、临终关怀和临终关怀(PCEOL)研究。为进一步发展PCEOL而计划的步骤将使其能够：(1)支持研究并开发未被研究的PCEOL领域的专业知识，如护理者和生物行为研究；(2)促进高效和快速地进行需要大样本和多地点的重要的尖端研究；(3)培养未来的研究人员以利用和维持企业，同时继续建立PCEOL证据库；以及(4)描述、量化和了解限制生命的疾病对多种相关结果的风险、问题和影响，包括患者和照顾者的健康结果以及生物行为干预和结果。具体地说，我们建议迅速提高PCRC的能力，以开发和进行一系列多样化的高质量研究，以应对科学知识中的关键差距。我们将通过以下具体目标实现这些目标：(1)发展合作、多站点、PCEOL研究的国家研究能力，以最大限度地提高研究的质量和效率以及合作小组的有效性；以及(2)为PCEOL研究提供综合支持，特别是为进行、分析和传播具有临床意义的、高质量、高效、以患者为中心的多站点研究提供综合支持。实现这些目标的综合结果将是一个高效、适应性和标准化的系统，以推进PCEOL研究中优先考虑的、创新的、严格设计和执行的研究，特别是需要多个招募地点的临床试验。

DESCRIPTION (provided by applicant): In 2010, the Palliative Care Research Cooperative Group (PCRC) was developed as a national collaborative research network to become the scalable, supportive structure so critically needed for the conduct of high quality clinical trials Work proposed under the current grant will build on the accomplishments achieved during the initial NINR funding for the PCRC (UC4NR012584). The overarching objective of this U24 grant application is to amplify the role of the PCRC as a national resource for efficient conduct of high quality, collaborative, multisite, palliative care and end-of-life (PCEOL) research by leveraging and building upon the prior NINR investment and accomplishments of the PCRC to date. The steps planned for further PCRC development will enable it to: (1) support research and develop expertise in understudied PCEOL areas such as caregiver and bio-behavioral research; (2) facilitate efficient and expeditious conduct of important, cutting-edge studies that require large samples and multiple sites; (3) prepare future researchers to utilize and sustain the enterprise, while continuing to build the PCEOL evidence base, and; (4) describe, quantify, and understand the risks, issues, and impact of life-limiting disease on multiple relevant outcomes including health outcomes for patients and caregivers and bio-behavioral interventions and outcomes. Specifically, we propose to rapidly increase the capacity of the PCRC to develop and conduct a diversified portfolio of high quality research studies that are responsive to key gaps in the scientific knowledge. We will achieve these goals through the following specific aims: (1) develop a national research capacity for collaborative, multisite, PCEOL research in a way that maximizes the quality and efficiency of research and the effectiveness of cooperative groups; and (2) provide integrated support for PCEOL research, specifically, for the conduct, analysis, and dissemination of clinically meaningful, high-quality, efficient, patient-centered, multisite studies. The combined result of achieving these aims will be a highly efficient, adaptive, and standardized system to advance prioritized, innovative, rigorously designed and performed, studies in PCEOL research, with a particular emphasis on clinical trials requiring multiple recruitment sites.