Palliative Care Research Cooperative Group (PCRC): Refinement and Expansion

项目摘要/摘要 临终关怀(EOLPC)旨在提高严重疾病患者和患者的生活质量 照顾者。EOLPC的需求和交付远远超过了提供证据的研究 最佳实践。小规模、单部位试验、不具代表性的研究队列和缺乏足够严谨性的研究 妨碍提供高质量的EOLPC。虽然其他领域的证据已经通过大型， 多种多样的多点试验，EOLPC研究因基础设施和科学研究不足而受阻 劳动力。此U2C应用程序的主要目标是提高工作效率和影响 姑息关怀研究合作小组(PCRC)，其促进高质量开展的能力， 有效的临床研究，并扩大姑息治疗研究人员的数量和专业知识 多点临床试验。PCRC致力于推动EOLPC的科学研究，为调查人员提供 进行大规模、多地点临床试验和其他研究研究所需的广泛支持。 这种支持包括培训机会、试点拨款奖励、访问大型集中式数据存储库 从EOLPC研究、方法咨询、研究活动的行政协调和获取 到一个庞大的潜在学习招生地点网络。从结构上讲，PCRC由六个协作体组成 各组成部分，每个由一名EOLPC高级研究员领导。项目协调中心统筹协调 筹委会的行政管理。调查员发展中心培养EOLPC研究人员的技能。 四个核心提供方法专业知识：数据、信息学和统计；测量；护理人员 研究；和临床研究/方法论。U2C PCRC应用解决了科学性、可操作性、 能力建设和合作目标。通过实现这些目标，太平洋投资促进委员会将扩大其能力，以 支持由跨学科EOLPC研究人员组成的强大社区，这些研究人员解决指导交付的主题 姑息治疗的最终目标是改善严重疾病患者的生活和他们的 照顾者。

PROJECT SUMMARY/ABSTRACT End of life and palliative care (EOLPC) seeks to enhance quality of life for those with serious illness and their caregivers. The need for and delivery of EOLPC have far exceeded the research that provides evidence of best practices. Small, single-site trials, unrepresentative study cohorts, and studies lacking sufficient rigor hamper provision of high-quality EOLPC. While other fields have advanced their evidence through large, diverse, multi-site trials, EOLPC research has been impeded by an insufficient infrastructure and scientific workforce. The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. The PCRC strives to advance the science of EOLPC by providing investigators with the broad range of support necessary to conduct large scale, multi-site clinical trials and other research studies. This support includes training opportunities, pilot grant awards, access to a large, centralized repository of data from EOLPC studies, methodologic consultation, administrative coordination of research activities, and access to a large network of potential study enrollment sites. Structurally, the PCRC consists of six synergistic components, each led by a senior EOLPC researcher. The Project Coordinating Center coordinates overall administration of the PCRC. The Investigator Development Center builds the skills of EOLPC researchers. Four Cores provide methodological expertise: Data, Informatics, and Statistics; Measurement; Caregiver Research; and Clinical Studies/Methodology. The U2C PCRC application addresses Scientific, Operational, Capacity-building, and Collaborative Aims. By accomplishing these aims, the PCRC will expand its ability to support a robust community of interdisciplinary EOLPC researchers who address topics that guide the delivery of palliative care with an ultimate goal of improving the lives of patients with serious illness and their caregivers.