Palliative Care Research Cooperative Group (PCRC): Refinement and Expansion

姑息治疗研究合作小组 (PCRC)：细化和扩展

• 批准号: 10207778
• 负责人: JEAN S KUTNER
• 金额: $ 150.98万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-28 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207778
• 关键词: Address; Administrative Coordination; Aging; Area; Award; Caregiver research; Caregivers; Caring; Childhood; Clinical Research; Cohort Studies; Collaborations; Communities; Consultations; Data; Data Science; Development; Discipline; Distress; Economically Deprived Population; Economics; Enrollment; Ensure; Fostering; Goals; Grant; Informatics; Infrastructure; Interdisciplinary Study; Intervention; Investments; Joints; Measurement; Medical; Methodological Studies; Methodology; Multi-Institutional Clinical Trial; Outcome; Palliative Care; Patient Care; Patients; Persons; Population; Population Heterogeneity; Procedures; Process; Productivity; Quality of life; Research; Research Activity; Research Personnel; Research Support; Resources; Science; Site; Standardization; Structure; Support Groups; Therapeutic; Time; Training; Translating; Underrepresented Minority; advanced disease; care seeking; clinical research site; data repository; empowered; end of life; evidence base; improved; knowledge translation; multi-site trial; multiple chronic conditions; pragmatic trial; prevent; psychosocial; research study; skills; statistics; success; training opportunity

PROJECT SUMMARY/ABSTRACT End of life and palliative care (EOLPC) seeks to enhance quality of life for those with serious illness and their caregivers. The need for and delivery of EOLPC have far exceeded the research that provides evidence of best practices. Small, single-site trials, unrepresentative study cohorts, and studies lacking sufficient rigor hamper provision of high-quality EOLPC. While other fields have advanced their evidence through large, diverse, multi-site trials, EOLPC research has been impeded by an insufficient infrastructure and scientific workforce. The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. The PCRC strives to advance the science of EOLPC by providing investigators with the broad range of support necessary to conduct large scale, multi-site clinical trials and other research studies. This support includes training opportunities, pilot grant awards, access to a large, centralized repository of data from EOLPC studies, methodologic consultation, administrative coordination of research activities, and access to a large network of potential study enrollment sites. Structurally, the PCRC consists of six synergistic components, each led by a senior EOLPC researcher. The Project Coordinating Center coordinates overall administration of the PCRC. The Investigator Development Center builds the skills of EOLPC researchers. Four Cores provide methodological expertise: Data, Informatics, and Statistics; Measurement; Caregiver Research; and Clinical Studies/Methodology. The U2C PCRC application addresses Scientific, Operational, Capacity-building, and Collaborative Aims. By accomplishing these aims, the PCRC will expand its ability to support a robust community of interdisciplinary EOLPC researchers who address topics that guide the delivery of palliative care with an ultimate goal of improving the lives of patients with serious illness and their caregivers.

项目摘要/摘要 生命的终结和姑息治疗（EOLPC）试图提高患有严重疾病及其的人的生活质量 照顾者。 EOLPC的需求和交付远远超出了提供的研究，提供了证据 最佳实践。小型单位试验，非代表性研究队列和缺乏足够严格的研究 障碍提供高质量的EOLPC。虽然其他领域的证据通过了大规模，但 EOLPC的多样化的多站点试验受到了不足的基础设施和科学的影响 劳动力。该U2C应用的主要目标是提高 姑息治疗研究合作小组（PCRC），其促进高质量行为的能力， 有效的临床研究，并扩大姑息治疗研究人员的数量和专业知识 多站点临床试验。 PCRC通过为调查人员提供了EOLPC科学的努力 进行大规模的多站点临床试验和其他研究所需的广泛支持。 此支持包括培训机会，试点赠款奖，访问大型的集中式数据存储库 根据EOLPC研究，方法学咨询，研究活动的行政协调以及访问 到一个大型潜在研究入学地点网络。在结构上，PCRC由六个协同作用组成 组件，每个组件由高级EOLPC研究人员领导。项目协调中心总体协调 PCRC的给药。研究人员开发中心建立了EOLPC研究人员的技能。 四个核心提供方法论专业知识：数据，信息学和统计数据；测量;照料者 研究;和临床研究/方法论。 U2C PCRC应用程序涉及科学，操作， 能力建设和协作目标。通过实现这些目标，PCRC将扩大其能力 支持一个强大的跨学科EOLPC研究人员的社区，他们谈到指导交付的主题 姑息治疗的最终目标是改善严重疾病的患者的生活 照顾者。