Palliative Care Research Cooperative Group (PCRC): Refinement and Expansion

姑息治疗研究合作小组 (PCRC)：细化和扩展

• 批准号: 10331658
• 负责人: JEAN S KUTNER
• 金额: $ 21.77万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-28 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10331658
• 关键词: Address; Administrative Coordination; Affect; Age; American; Award; Awareness; Behavioral; COVID-19; COVID-19 pandemic; COVID-19 vaccination; COVID-19 vaccine; Caregiver research; Caregivers; Caring; Clinical; Clinical Research; Cohort Studies; Color; Communication; Communities; Consultations; Contracts; Data; Decision Making; Development; Disincentive; Economics; Enrollment; Environment; Epidemic; Ethics; Extended Family; Face; Family; Female; Foundations; Funding; Generations; Goals; Grant; Health; Health Campaign; Health behavior; Healthcare; Hearing; Home; Home Health Aides; Hospice Care; Hospitals; Immigrant; Incentives; Individual; Informatics; Infrastructure; Internships; Interview; Measurement; Medical; Methodological Studies; Methodology; Minority Groups; Modeling; Multi-Institutional Clinical Trial; National Institute of Nursing Research; Neighborhoods; New York City; Nurses; Palliative Care; Patients; Persons; Pharmacists; Physicians; Policies; Population; Population Heterogeneity; Poverty; Process; Productivity; Public Health; Quality of life; Research; Research Activity; Research Personnel; Risk; Role; SARS-CoV-2 infection; SARS-CoV-2 transmission; Science; Site; Source; Structure; Travel; Trust; Underrepresented Populations; Underserved Population; Vaccination; Voice; Vulnerable Populations; Woman; Work; adverse outcome; base; care seeking; community engagement; community organizations; data privacy; data repository; end of life; ethnic minority population; experience; federal poverty level; health literacy; high risk; hospice environment; improved; influenza virus vaccine; insight; multi-site trial; multidisciplinary; pandemic disease; peer; personal protective equipment; racial minority; research study; skills; social; social vulnerability; socioeconomics; statistics; therapy design; training opportunity; uptake; vaccine hesitancy

PROJECT SUMMARY/ABSTRACT End of life and palliative care (EOLPC) seeks to enhance quality of life for those with serious illness and their caregivers. The need for and delivery of EOLPC have far exceeded the research that provides evidence of best practices. Small, single-site trials, unrepresentative study cohorts, and studies lacking sufficient rigor hamper provision of high-quality EOLPC. While other fields have advanced their evidence through large, diverse, multi-site trials, EOLPC research has been impeded by an insufficient infrastructure and scientific workforce. The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. The PCRC strives to advance the science of EOLPC by providing investigators with the broad range of support necessary to conduct large scale, multi-site clinical trials and other research studies. This support includes training opportunities, pilot grant awards, access to a large, centralized repository of data from EOLPC studies, methodologic consultation, administrative coordination of research activities, and access to a large network of potential study enrollment sites. Structurally, the PCRC consists of six synergistic components, each led by a senior EOLPC researcher. The Project Coordinating Center coordinates overall administration of the PCRC. The Investigator Development Center builds the skills of EOLPC researchers. Four Cores provide methodological expertise: Data, Informatics, and Statistics; Measurement; Caregiver Research; and Clinical Studies/Methodology. The U2C PCRC application addresses Scientific, Operational, Capacity- building, and Collaborative Aims. By accomplishing these aims, the PCRC will expand its ability to support a robust community of interdisciplinary EOLPC researchers who address topics that guide the delivery of palliative care with an ultimate goal of improving the lives of patients with serious illness and their caregivers.

项目总结/摘要 生命结束和姑息治疗（EOLPC）旨在提高那些严重的生活质量， 疾病及其护理人员。EOLPC的需求和交付远远超过了 提供最佳实践证据的研究。小型、单中心试验，不具有代表性 研究队列和研究缺乏足够的严谨性阻碍了高质量EOLPC的提供。 虽然其他领域已经通过大型，多样化，多地点试验推进了他们的证据，EOLPC 基础设施和科研人员不足阻碍了研究工作。的 这种U2 C应用的主要目标是提高生产率和姑息治疗的影响 护理研究合作小组（PCRC），其能力，以促进高质量的， 有效的临床研究，并扩大姑息治疗的数量和专业知识 研究人员进行多中心临床试验。PCRC致力于推进科学， EOLPC通过向调查人员提供广泛的必要支持， 大规模、多中心临床试验和其他研究。这种支持包括培训 机会，试点赠款，访问EOLPC的大型集中数据库 研究、方法学咨询、研究活动的行政协调，以及 访问潜在研究入组研究中心的大型网络。在架构上，该委员会包括 六个协同组成部分，每个由一名高级EOLPC研究员领导。项目协调 中心协调PCRC的整体管理。研究者发展中心 培养EOLPC研究人员的技能。四个核心提供方法学专业知识：数据， 信息学和统计学;测量;护理人员研究;和临床 研究/方法。U2 C PCRC应用解决了科学、运营、能力 建设和合作目标。通过实现这些目标，该中心将扩大其能力 支持一个强大的跨学科EOLPC研究人员社区， 指导姑息治疗的提供，最终目标是改善患者的生活， 严重的疾病及其护理人员。