Palliative Care Research Cooperative Group (PCRC): Refinement and Expansion

姑息治疗研究合作小组 (PCRC)：细化和扩展

• 批准号: 10331658
• 负责人: JEAN S KUTNER
• 金额: $ 21.77万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-28 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10331658
• 关键词: Address; Administrative Coordination; Affect; Age; American; Award; Awareness; Behavioral; COVID-19; COVID-19 pandemic; COVID-19 vaccination; COVID-19 vaccine; Caregiver research; Caregivers; Caring; Clinical; Clinical Research; Cohort Studies; Color; Communication; Communities; Consultations; Contracts; Data; Decision Making; Development; Disincentive; Economics; Enrollment; Environment; Epidemic; Ethics; Extended Family; Face; Family; Female; Foundations; Funding; Generations; Goals; Grant; Health; Health Campaign; Health behavior; Healthcare; Hearing; Home; Home Health Aides; Hospice Care; Hospitals; Immigrant; Incentives; Individual; Informatics; Infrastructure; Internships; Interview; Measurement; Medical; Methodological Studies; Methodology; Minority Groups; Modeling; Multi-Institutional Clinical Trial; National Institute of Nursing Research; Neighborhoods; New York City; Nurses; Palliative Care; Patients; Persons; Pharmacists; Physicians; Policies; Population; Population Heterogeneity; Poverty; Process; Productivity; Public Health; Quality of life; Research; Research Activity; Research Personnel; Risk; Role; SARS-CoV-2 infection; SARS-CoV-2 transmission; Science; Site; Source; Structure; Travel; Trust; Underrepresented Populations; Underserved Population; Vaccination; Voice; Vulnerable Populations; Woman; Work; adverse outcome; base; care seeking; community engagement; community organizations; data privacy; data repository; end of life; ethnic minority population; experience; federal poverty level; health literacy; high risk; hospice environment; improved; influenza virus vaccine; insight; multi-site trial; multidisciplinary; pandemic disease; peer; personal protective equipment; racial minority; research study; skills; social; social vulnerability; socioeconomics; statistics; therapy design; training opportunity; uptake; vaccine hesitancy

PROJECT SUMMARY/ABSTRACT End of life and palliative care (EOLPC) seeks to enhance quality of life for those with serious illness and their caregivers. The need for and delivery of EOLPC have far exceeded the research that provides evidence of best practices. Small, single-site trials, unrepresentative study cohorts, and studies lacking sufficient rigor hamper provision of high-quality EOLPC. While other fields have advanced their evidence through large, diverse, multi-site trials, EOLPC research has been impeded by an insufficient infrastructure and scientific workforce. The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. The PCRC strives to advance the science of EOLPC by providing investigators with the broad range of support necessary to conduct large scale, multi-site clinical trials and other research studies. This support includes training opportunities, pilot grant awards, access to a large, centralized repository of data from EOLPC studies, methodologic consultation, administrative coordination of research activities, and access to a large network of potential study enrollment sites. Structurally, the PCRC consists of six synergistic components, each led by a senior EOLPC researcher. The Project Coordinating Center coordinates overall administration of the PCRC. The Investigator Development Center builds the skills of EOLPC researchers. Four Cores provide methodological expertise: Data, Informatics, and Statistics; Measurement; Caregiver Research; and Clinical Studies/Methodology. The U2C PCRC application addresses Scientific, Operational, Capacity- building, and Collaborative Aims. By accomplishing these aims, the PCRC will expand its ability to support a robust community of interdisciplinary EOLPC researchers who address topics that guide the delivery of palliative care with an ultimate goal of improving the lives of patients with serious illness and their caregivers.

项目概要/摘要 临终关怀和姑息治疗 (EOLPC) 旨在提高患有严重疾病的人的生活质量 疾病及其照顾者。 EOLPC 的需求和交付量已远远超过 提供最佳实践证据的研究。小型、单中心试验，不具有代表性 研究队列和缺乏足够严谨的研究阻碍了高质量 EOLPC 的提供。 虽然其他领域已经通过大型、多样化、多地点试验提出了证据，但 EOLPC 研究因基础设施和科学劳动力不足而受到阻碍。这 该 U2C 应用程序的主要目标是提高姑息治疗的生产力和影响 护理研究合作组织 (PCRC)，其有能力促进高质量、 有效的临床研究，并扩大姑息治疗的数量和专业知识 研究人员进行多中心临床试验。 PCRC 致力于推动科学发展 EOLPC 为研究人员提供开展大规模研究所需的广泛支持 规模、多地点临床试验和其他研究。这种支持包括培训 机会、试点补助金、访问 EOLPC 的大型集中式数据存储库 研究、方法咨询、研究活动的行政协调，以及 访问庞大的潜在学习注册地点网络。 PCRC 的结构包括 六个协同组件，每个组件均由高级 EOLPC 研究员领导。项目协调 中心协调 PCRC 的整体管理。研究者发展中心 培养 EOLPC 研究人员的技能。四个核心提供方法论专业知识：数据、 信息学和统计学；测量;护理人员研究；和临床 研究/方法论。 U2C PCRC 应用程序涉及科学、操作、能力- 建设和协作目标。通过实现这些目标，PCRC 将扩大其能力 支持强大的跨学科 EOLPC 研究人员社区，他们解决的主题 指导姑息治疗的实施，最终目标是改善患者的生活 严重疾病及其照顾者。