Monitoring Particulate, PAH, Allergen and Microbial Exposures in Asthmatic Kids
监测哮喘儿童的颗粒物、PAH、过敏原和微生物暴露
基本信息
- 批准号:9076745
- 负责人:
- 金额:$ 197.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-30 至 2020-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAllergicArchivesAsthmaBindingBiological AssayCarbon BlackCellular PhoneChildCollectionCommunitiesDataData Coordinating CenterDetectionDevelopmentDevicesDictyopteraElementsEnvironmentEnvironmental Risk FactorEpidemicEpidemiologic StudiesEpidemiologistEpidemiologyFutureGasesGoalsGrantHeredityHome environmentHourIntervention StudiesLaboratoriesLife Cycle StagesLocationMeasurementMeasuresMethodsMiniaturizationMinorityModelingMonitorMorbidity - disease rateMusOpticsOutcomeParticulateParticulate MatterPhasePhysiologicalPolytetrafluoroethylenePopulationPrevalenceProductionProtocols documentationReproducibilityResearchResearch DesignResearch PersonnelSamplingSignal TransductionSisterStagingStreamSymptomsTestingTimeUpdateValidationVariantWireless TechnologyWorkair monitoringairborne allergenanalytical methodasthmaticbasecockroach allergencohortdata exchangedata visualizationdesigndiariesimprovedindoor allergeninterestmicrobialmicrobial allergenminiaturizenovelparticlepreventprototypepublic health relevancepyroglyphidsensorspatial temporal variationstressortooltransmission processultravioletwood smoke
项目摘要
DESCRIPTION (provided by applicant): In the proposed study, we will integrate a modular array of miniaturized air monitors for use as personal and residential monitors for future epidemiological studies that will test hypotheses on asthma development and asthma exacerbation. Our overall approach is to develop and test (a) a real-time monitor that can serve as a platform to record its own data and data from other monitors to establish spatial and temporal variations of potential acute asthma stressors and (b) a monitor that can collect either spatially- or time- resolved, integrated samples that can be archived for subsequent analysis in the laboratory. Time scales for battery-powered deployments of both the real-time monitors and the integrated sampler could range from 24 hours to a month in duration depending on the study design. Three aims form our proposal. Aim 1) Integrate a modular array of miniaturized air monitors for use as residential and personal monitors. The three monitors that make up our modular array currently exist in various stages of development: a completed monitor that is not fully validated (the Multi-day microAeth(r)), a prototype that will be further miniaturized while expanding functionality (the Archive Monitor) and an off the shelf inexpensive smart phone enabled monitor for airborne particulates (The Airbeam from Aircasting.org). Tri-axial accelerometer and GPS chips are integrated into our personal monitors allowing determinations of location, wearing compliance and activity related parameters. The multi-day microAeth monitor, measures optically absorbant components of particulate matter including black carbon and environmental wood smoke. Bluetooth, WiFi and/or serial connections will allow all sensor data to be logged on the multi-day microAeth(r) to simplify integration and allow all sensor data (personal and residential) to be sent to the study team on a daily basis. We include the Airbeam to show capacity of our platform for integrating data streams from third-party monitors and to show capacity for integrating our sensor data into a pre-existing smart phone app. Aim 2) Refine or develop sensitive analytical methods for a wide suite of asthma-related exposure measurements for archive, integrated samples of PM10, PM2.5 and semi-volatile compounds. The initial suite of measurements to be validated for the archive samples includes airborne allergens (mouse, dust mite and cockroach), PCR based microbial assays, semi-volatile and particle-associated non-volatile PAHs, black carbon, particulate-bound elements, and gravimetric determinations of PM10 and PM2.5 filters. Aim 3) Carry out laboratory and field tests iteratively to identify challenges in using the devices, improve protocols, and determine reproducibility and accuracy of collected data. Field tests will include comparisons to other monitors and feasibility pilots with a cohort of asthmatic children for testing the modular array o air monitors. Feasibility outcomes of interest include data completeness, wearing compliance, and demonstration of the ability to transfer data to future data coordinating centers.
描述(由申请人提供):在拟议的研究中,我们将整合一个小型空气监测器的模块化阵列,用作个人和住宅监测器,用于未来的流行病学研究,将测试哮喘发展和哮喘加重的假设。我们的总体方法是开发和测试(a)实时监测器,其可以用作记录其自身数据和来自其他监测器的数据的平台,以建立潜在急性哮喘应激源的空间和时间变化,以及(B)监测器,其可以收集空间或时间分辨的、集成的样品,其可以存档用于实验室中的后续分析。根据研究设计,电池供电的实时监测器和集成采样器部署的时间范围可以从24小时到一个月不等。我们的建议有三个目的。 目标1)集成微型空气监测器的模块化阵列,用作住宅和个人监测器。组成我们模块化阵列的三个监测器目前处于不同的开发阶段:一个尚未完全验证的完整监测器(Multi-day microAeth(r)),一个在扩展功能的同时将进一步小型化的原型(Archive Monitor)和一个现成的廉价智能手机支持的空气颗粒监测器(来自Aircasting.org的Airbeam)。三轴加速度计和GPS芯片集成到我们的个人监视器中,允许确定位置,佩戴合规性和活动相关参数。多天microAeth监测仪,测量颗粒物的光学吸收成分,包括黑碳和环境木材烟雾。蓝牙、WiFi和/或串行连接将允许所有传感器数据记录在多天microAeth(r)上,以简化集成,并允许每天将所有传感器数据(个人和住宅)发送给研究团队。我们将Airbeam包括在内,以展示我们平台整合来自第三方监测器的数据流的能力,并展示将我们的传感器数据整合到现有智能手机应用程序中的能力。目标2)完善或开发灵敏的分析方法,用于广泛的哮喘相关暴露测量,用于PM10、PM2.5和半挥发性化合物的存档、整合样本。档案样本的初始测量套件包括空气中的过敏原(小鼠,尘螨和蟑螂),基于PCR的微生物测定,半挥发性和颗粒相关的非挥发性多环芳烃,黑碳,颗粒结合元素,以及PM10和PM2.5过滤器的重量测定。 目标3)反复进行实验室和现场测试,以确定使用设备的挑战,改进方案,并确定收集数据的重现性和准确性。现场测试将包括与其他监测器的比较,以及与哮喘儿童队列的可行性试验,以测试空气监测器的模块化阵列。感兴趣的可行性结果包括数据完整性,磨损合规性,以及将数据传输到未来数据协调中心的能力证明。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Steven N. Chillrud其他文献
Absolute doubly differential angular sputtering yields for 20 keV Kr+ on polycrystalline Cu
多晶铜上 20 keV Kr+ 的绝对双微分角溅射产量
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:3.2
- 作者:
Caixia Bu;L. Morrissey;Benjamin C. Bostick;M. Burger;Kyle P Bowen;Steven N. Chillrud;D. Domingue;Catherine A. Dukes;D. Ebel;G. Harlow;P. Hillenbrand;Dmitry A. Ivanov;R. Killen;James M. Ross;Daniel Schury;O. Tucker;Xavier Urbain;Ruitian Zhang;D. W. Savin - 通讯作者:
D. W. Savin
Widespread Pb contamination in urban backyard soils for 100 years identified in soil cores constrained by sup210/supPb and sup137/supCs
通过受 sup210/supPb 和 sup137/supCs 限制的土壤核心确定了城市后院土壤中 100 年来广泛的铅污染
- DOI:
10.1016/j.scitotenv.2023.165407 - 发表时间:
2023-11-15 - 期刊:
- 影响因子:8.000
- 作者:
Franziska C. Landes;Margaret Calcio;Jennifer M. Sobolewski;Kelcey Wallens-Logan;Anna Ledeczi;Yael Kiro;Louise Bolge;James Ross;Steven N. Chillrud;Brian J. Mailloux;Alexander van Geen - 通讯作者:
Alexander van Geen
Steven N. Chillrud的其他文献
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{{ truncateString('Steven N. Chillrud', 18)}}的其他基金
High Resolution Models of Groundwater Metal Exposures
地下水金属暴露的高分辨率模型
- 批准号:
10354269 - 财政年份:2022
- 资助金额:
$ 197.8万 - 项目类别:
High Resolution Models of Groundwater Metal Exposures
地下水金属暴露的高分辨率模型
- 批准号:
10707888 - 财政年份:2022
- 资助金额:
$ 197.8万 - 项目类别:
Potential inhaled dose of particulates, biking and cardiovascular indicators
颗粒物的潜在吸入剂量、骑行和心血管指标
- 批准号:
9441097 - 财政年份:2017
- 资助金额:
$ 197.8万 - 项目类别:
Potential Inhaled Dose of Particulates, Biking and Cardiovascular Indicators
颗粒物、骑行和心血管指标的潜在吸入剂量
- 批准号:
8801250 - 财政年份:2015
- 资助金额:
$ 197.8万 - 项目类别:
High Precision Robotic Weighing System in Support of New Exposure Health Studies
支持新暴露健康研究的高精度机器人称重系统
- 批准号:
8447261 - 财政年份:2013
- 资助金额:
$ 197.8万 - 项目类别:
Validating Particulate Matter Monitors for Multiple Parameters
验证颗粒物监测仪的多个参数
- 批准号:
8179830 - 财政年份:2011
- 资助金额:
$ 197.8万 - 项目类别:
Validating Particulate Matter Monitors for Multiple Parameters
验证颗粒物监测仪的多个参数
- 批准号:
8331370 - 财政年份:2011
- 资助金额:
$ 197.8万 - 项目类别:
Smart Miniaturized personal monitors for black carbon and multiple air pollutants
智能微型个人黑碳和多种空气污染物监测仪
- 批准号:
7485240 - 财政年份:2007
- 资助金额:
$ 197.8万 - 项目类别:
Smart Miniaturized personal monitors for black carbon and multiple air pollutants
智能微型个人黑碳和多种空气污染物监测仪
- 批准号:
7921792 - 财政年份:2007
- 资助金额:
$ 197.8万 - 项目类别:
Smart Miniaturized personal monitors for black carbon and multiple air pollutants
智能微型个人黑碳和多种空气污染物监测仪
- 批准号:
7638931 - 财政年份:2007
- 资助金额:
$ 197.8万 - 项目类别:
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