Gene-Environment Interplay and Development of Psychiatric Symptoms in Children

基因-环境相互作用与儿童精神症状的发展

• 批准号: 8676939
• 负责人: Leslie Diane Leve
• 金额: $ 61.77万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-28 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676939
• 关键词: 6 year old; Adolescence; Adolescent; Adoption; Adult; Age; Age-Years; Aggressive behavior; Alcohol or Other Drugs use; Anxiety; Area; Behavior; Behavioral; Behavioral Symptoms; Birth; Child; Child Behavior; Child Rearing; Childhood; Collection; DNA; Data; Data Collection; Data Set; Development; Diagnostic; Disease; Economics; Emotional; Emotions; Environment; Event; Exposure to; Family; Genes; Genetic; Genetic Predisposition to Disease; Genetic Risk; Growth and Development function; Guide prevention; High Prevalence; Home environment; Individual; Life; Link; Marital Relationships; Measurement; Measures; Mediating; Mental Depression; Mental disorders; Parenting behavior; Parents; Participant; Pathway interactions; Pattern; Phase; Prevalence; Primary Schools; Productivity; Recruitment Activity; Resource Allocation; Resources; Risk; Role; Sampling; Societies; Stress; Substance abuse problem; Symptoms; Temperament; Time; Work; adopted child; anti social; cohort; cost; depressive symptoms; design; early childhood; externalizing behavior; genetic risk factor; infancy; insight; longitudinal design; postnatal; prenatal; prenatal experience; prenatal exposure; prenatal influence; prenatal risk factor; prenatal stress; prospective; resilience

DESCRIPTION (provided by applicant): This project utilizes an adoption design to examine the interplay between genetic, prenatal, and postnatal environmental influences on early pathways to conduct, anxiety, and depressive problems by (a) conducting a psychiatric assessment of adopted children between 6.0 and 7.5 years of age and (b) conducting a psychiatric assessment of adoptive parents. Psychiatric assessments of the birth parents have already been conducted and these data will be utilized in the proposed analyses. In addition, DNA is being collected on all participants and will be available for analysis in the present study. The present study builds on a longitudinal prospective adoption study conducted during early childhood: two cohorts of adopted children and their birth and adoptive parents were recruited and assessed across 3 - 6 waves from infancy through early childhood (Early Growth and Development Study; EGDS-Cohort I, R01 HD42608 and EGDS-Cohort II, R01 DA020585). Combined with the rich existing data, the proposed data will allow us to better characterize early emerging emotional and behavioral symptoms in children that have been shown to predict later psychiatric problems. Because we will have DNA samples and data from birth and adoptive parents, we will be able to disentangle how prenatal, genetic, and rearing environment factors are related to early emerging emotional and behavioral symptoms, as well as to later psychiatric symptoms. To our knowledge, no other existing dataset or resource exists that can disentangle and examine the interplay among genetic, prenatal, and postnatal environmental influences on the development of symptoms in young children. The proposed study will allow us to achieve the following specific aims: SA1: Identify early emerging behaviors and emotions in children that predict onset of psychiatric symptoms in young children; SA2: Examine prenatal exposure to substances and prenatal stress in exacerbating genetic risk for psychiatric symptoms; SA3: Consider the mediating and moderating role of the rearing environment on prenatal and genetic risk factors on psychiatric symptoms in childhood; SA4: Assess how adoptive parents' stress and their own psychiatric symptoms impact the rearing environment and mediate and/or moderate genetic and prenatal influences.

描述（由申请人提供）：本项目采用收养设计，通过（a）对6.0至7.5岁的收养儿童进行精神评估和（B）对养父母进行精神评估，研究遗传、产前和产后环境对早期行为、焦虑和抑郁问题的影响之间的相互作用。已经对亲生父母进行了精神病学评估，这些数据将用于拟定的分析。此外，正在收集所有参与者的DNA，并将在本研究中进行分析。本研究建立在儿童早期进行的纵向前瞻性收养研究的基础上：招募了两个队列的收养儿童及其亲生父母和养父母，并从婴儿期到儿童早期进行了3 - 6次评估（早期生长和发育研究; EGDS-队列I，R 01 HD 42608和EGDS-队列II，R 01 DA 020585）。结合丰富的现有数据，拟议的数据将使我们能够更好地描述儿童早期出现的情绪和行为症状，这些症状已被证明可以预测后期的精神问题。因为我们将有来自亲生父母和养父母的DNA样本和数据，我们将能够解开产前，遗传和养育环境因素与早期出现的情绪和行为症状以及后期精神症状的关系。据我们所知，没有其他现有的数据集或资源存在，可以解开和检查遗传，产前和产后环境对幼儿症状发展的影响之间的相互作用。拟议的研究将使我们能够实现以下具体目标：SA 1：确定儿童早期出现的行为和情绪，预测幼儿精神症状的发作; SA 2：检查产前暴露于物质和产前压力，加剧精神症状的遗传风险; SA 3：考虑养育环境对产前和遗传风险因素对儿童期精神症状的中介和调节作用; SA 4：评估养父母的压力和他们自己的精神症状如何影响养育环境和中介和/或适度的遗传和产前影响。

项目成果

Correction to: Examining the Role of Genetic Risk and Longitudinal Transmission Processes Underlying Maternal Parenting and Psychopathology and Children's ADHD Symptoms and Aggression: Utilizing the Advantages of a Prospective Adoption Design.

更正：检查母亲养育和精神病理学以及儿童多动症症状和攻击行为背后的遗传风险和纵向传播过程的作用：利用前瞻性收养设计的优势。

• DOI: 10.1007/s10519-021-10061-z
• 发表时间: 2021
• 期刊: Behavior genetics
• 影响因子: 2.6
• 作者: Sellers,Ruth;Harold,GordonT;Thapar,Anita;Neiderhiser,JenaeM;Ganiban,JodyM;Reiss,David;Shaw,DanielS;Natsuaki,MisakiN;Leve,LeslieD
• 通讯作者: Leve,LeslieD