Hispanic Satellite Core

西班牙卫星核心

• 批准号: 8676146
• 负责人: Tamar Gollan
• 金额: $ 31.77万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676146
• 关键词: Address; Affect; Age; Aging; Alzheimer' s Disease; Area; Attitude; Authorization documentation; Autopsy; Awareness; Biological; Biological Markers; Blood Vessels; Brain; Brain imaging; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Trials; Cognition; Cognitive; Consent; DNA; Data; Data Coordinating Center; Data Set; Databases; Dementia; Development; Diagnosis; Diagnostic; Disease; Dropout; Early treatment; Education; Effectiveness; Elderly; Enrollment; Environment; Equilibrium; Evaluation; Family; Fostering; Funding; Genetic; Genotype; Goals; Health; Hispanics; Image; Impaired cognition; Impairment; Individual; Information Dissemination; Inherited; Institution; Interdisciplinary Study; Knowledge; Language; Magnetic Resonance Imaging; Measures; Medical center; Neurological Nursing; Neuropsychological Tests; Not Hispanic or Latino; Other Genetics; Participant; Patients; Pharmacologic Substance; Plasma; Prevention; Procedures; Professional Education; Protocols documentation; Recruitment Activity; Registries; Research; Research Personnel; Research Project Grants; Research Subjects; Research Support; Research Training; Resources; Risk; Risk Factors; Sampling; Spinal Puncture; TNFRSF5 gene; Training; abstracting; bilingualism; cognitive change; cognitive reserve; cohort; cooperative study; improved; innovation; instrument; interest; mild cognitive impairment; neuropsychological; pre-clinical; research clinical testing; research study; socioeconomics; tool; willingness

CORE F: HISPANIC SATELLITE - ABSTRACT There were about 46 million Hispanics in the USA in 2010. Elderly Hispanics are at risk for dementia, due to Alzheimer's Disease (AD) and vascular risk factors. The UCSD ADRC's studies of aging and dementia among Hispanics aim to improve our understanding of AD and related disorders and to overcome barriers to effective assessment, diagnosis and treatment of early (and even preclinical) disease. The Satellite will support general research in aging and dementia, because subjects will undergo the same procedures, including biomarker studies and request for autopsy consent, as non-Hispanic subjects in the ADRC, and will contribute to research projects and clinical trials. In addition, the Satellite will support research into aspects unique to Hispanics, including 1) the influence of bilingualism and low education on diagnostic assessment and in cognitive reserve and dementia risk; 2) genetic, vascular, and socio-economic risk factors for cognitive decline and dementia. Overall aims for the Hispanic Satellite in this ADRC renewal application are to: 1) Support research efforts by recruiting and following well-characterized Hispanic subjects with normal cognition, Mild Cognitive Impairment (MCI), and AD. The Satellite will follow about 100 subjects (the balance between continued recruitment and death and dropout). Subjects will undergo standard clinical characterization (including the Uniform Data Set procedures). Biological samples (DNA, plasma and CSF), MRI and other brain images will be obtained. A comprehensive database will be maintained. Subjects will continue to contribute to autopsy studies after death. Data, biosamples and brain imaging studies from Hispanic Satellite subjects will be integrated with those from non-Hispanics followed by the Clinical Core. 2) Interact widely with researchers at UCSD, the VA Medical Center, and nearby research institutions. In particular, support ongoing funded research studies on bilingualism and on brain imaging and cognitive changes in aging in relation to APOE genotype and vascular risk factors. 4) Provide data to the National Alzheimer's Coordinating Center, and DNA to NCRAD, and collaborate with other AD Centers, and with multi-Center research efforts related to AD and dementia. Subjects will be offered participation in clinical trials organized by the Alzheimer's Disease Cooperative Study (ADCS), the Dominantly Inherited Alzheimer Network (DIAN), and by pharmaceutical companies. 5) Continue to support innovative research and train new investigators, 6) Foster professional education and training, and to improve public knowledge and awareness about aging, vascular and other risk factors that influence cognitive health in aging and dementia risk among Hispanics. To provide innovative support efforts for patients and families affected by AD.

核心F：西班牙卫星-摘要 2010年，美国约有4600万拉美裔人。西班牙裔老年人有患痴呆症的风险， 阿尔茨海默病（AD）和血管危险因素。UCSD ADRC对衰老和痴呆的研究 旨在提高我们对AD和相关疾病的理解， 有效评估、诊断和治疗早期（甚至临床前）疾病。该卫星将 支持对衰老和痴呆症的一般研究，因为受试者将经历相同的程序， 包括生物标志物研究和要求尸检同意，作为ADRC中的非西班牙裔受试者，以及 将有助于研究项目和临床试验。此外，该卫星还将支持研究 西班牙裔人特有的方面，包括1）双语和低教育对诊断的影响 评估和认知储备和痴呆风险; 2）遗传，血管和社会经济风险 认知能力下降和痴呆的因素。 西班牙卫星在ADRC更新申请中的总体目标是： 1)通过招募和跟踪特征良好的西班牙裔受试者来支持研究工作， 认知、轻度认知障碍（MCI）和AD。卫星将跟踪大约100个主题（ 继续招募与死亡和辍学之间的平衡）。受试者将接受标准临床 特征（包括统一数据集程序）。生物样本（DNA、血浆和CSF）， 将获得MRI和其他脑部图像。将维持一个综合数据库。受试者将 继续为死后的尸检研究做出贡献。数据、生物样本和脑成像研究， 西班牙裔卫星受试者将与非西班牙裔受试者合并，然后是临床核心受试者。 2)与UCSD，VA医疗中心和附近研究机构的研究人员进行广泛的互动。在 特别是，支持正在进行的双语研究和大脑成像和认知研究， 与APOE基因型和血管危险因素相关的衰老变化。 4)向国家阿尔茨海默氏症协调中心提供数据，向NCRAD提供DNA，并与 其他AD中心，以及与AD和痴呆症相关的多中心研究工作。受试者将 提供参与阿尔茨海默病合作研究（ADCS）组织的临床试验， 显性遗传阿尔茨海默病网络（DIAN）和制药公司。 5)继续支持创新研究和培训新的研究人员， 6)促进专业教育和培训，提高公众对老龄问题的认识和意识， 血管和其他危险因素影响拉美裔人的衰老和痴呆风险的认知健康。 为受AD影响的患者和家庭提供创新的支持。