Latino

拉丁裔

基本信息

批准号：
10615172
负责人：
Tamar Gollan
金额：
$ 23.98万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10615172
关键词：
Address African American population Aging Agreement Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Area Attitude Autopsy Awareness Behavioral Biological Markers Birth Brain California Cardiovascular system Caring Clinic Clinical Clinical Research Clinical Trials Clinical assessments Cognition Cognitive Communities County Data Set Databases Dementia Development Diagnosis Disease Disparity population Early Diagnosis Early treatment Education Effectiveness Elderly Enrollment Ensure Environment Epidemiology Exposure to General Practitioners Genetic Health Healthcare Hispanic Insurance Investigation Knowledge Language Latino Latino Population Life Expectancy Linguistics Memory Metabolic Methods Mexican Americans Names Neurocognitive Neurologic Neuropsychology Participant Patients Persons Physicians Population Positioning Attribute Procedures Program Evaluation Reduce health disparities Registries Reporting Research Research Personnel Research Project Grants Research Support Role Sampling Screening procedure Services Spinal Puncture Study of Latinos Subgroup Testing Underserved Population United States National Institutes of Health Validation Work age related base bilingualism brain health burden of illness care burden caucasian American clinical center clinical outcome measures cognitive change cognitive testing cohort diagnostic tool disparity reduction education research health disparity innovation interest mild cognitive impairment neuroimaging novel outreach pre-clinical recruit research study screening social disparities tool willingness

项目摘要

LATINO CORE - SUMMARY/ ABSTRACT Alzheimer’s disease and related dementias (ADRD) among U.S. Latinos are projected to increase over nine-fold from 379,000 in 2012 to 3.5 million by 2060. Latinos represent 18% of the U.S. population and about 40% of the population of California. Latinos lag behind Whites and African-Americans in education and healthcare insurance, and have cardiovascular, metabolic, and other disease burdens that exceed those of Whites; however, Latino life-expectancy at birth surpasses that of Whites by over 3-years giving them greater exposure to age-related risk of ADRD. Because of these factors, and cultural differences in reporting behavioral, cognitive, and functional deficits, state-of-the-art clinical, neuropsychological, and neurological procedures used to diagnose AD, that were largely developed and validated in relatively homogeneous, well- educated, White, English-speaking populations, may not work effectively with monolingual Spanish-speaking or Spanish-English bilingual older Latinos. Thus, there is a need for AD-related research in older Latinos to overcome barriers to effective screening, assessment, diagnosis and treatment of early and preclinical disease. There is also a need to better understand factors that impede or facilitate participation of elderly Latinos (particularly Mexican-Americans) in AD-related research, including awareness of AD and its clinical features, level of concern about the consequences of AD and burden of care, and willingness to participate in research including procedures such as sampling of biomarkers, genetics, and autopsy. To address these needs, the overall aims of the Latino Core are to: 1) conduct a linguistically- and culturally-appropriate memory screening and evaluation program in predominantly Latino areas in San Diego to develop and maintain a registry of well-characterized older Latino individuals who are interested in research and have agreed to be contacted about on-going AD-related research studies; 2) conduct developmental research to refine and evaluate linguistically- and culturally-appropriate clinical and cognitive assessment procedures to accurately identify MCI and the transition to AD dementia in older Latinos; 3) conduct developmental research to determine degree of knowledge and attitudes towards AD, brain health, and participation in all aspects of AD research in older Latinos; and 4) serve as a conduit between the activities of the ADRC and a large-scale epidemiology project on cognitive changes in older Latinos known as the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) and other new national and state-wide Latino research initiatives. This will allow participants identified with possible Mild Cognitive Impairment or ADRD to receive more extensive clinical and neuropsychological characterization and to participate in AD-related research projects, including clinical trials. Thus, the Latino Core will ensure that the ADRC is well positioned to study ADRD in this significant yet underserved population, filling critical gaps in scientific knowledge essential for reducing the disparities related to ADRD diagnosis, treatment and care facing Latinos in our San Diego community and beyond.

拉丁裔核心 - 摘要/摘要美国拉丁美洲人的阿尔茨海默氏病和相关痴呆症（ADRD）预计将增加从2012年的379,000到2060年的379,000倍。拉丁美洲人占美国人口的18％，大约占加利福尼亚人口的40％。拉丁美洲人落后于白人和非裔美国人教育和医疗保险，并具有超过的心血管，代谢和其他疾病伯恩斯白人；但是，出生时的拉丁裔预期生活超过了白人的3年以上，使他们更大暴露于与年龄有关的ADRD风险。由于这些因素以及报告中的文化差异行为，认知和功能性缺陷，最先进的临床，神经心理学和神经学用于诊断AD的程序，这些程序在相对均匀，良好的相对质量上得到了广泛开发和验证受过教育的，说英语的人群，可能与讲西班牙语的单语言无效或西班牙语英语双语的较老拉丁裔。那就是需要在较旧拉丁裔的广告相关研究克服有效筛查，评估，诊断和治疗早期和临床前的障碍疾病。还需要更好地理解阻碍或促进较早参与的因素与广告相关的研究中的拉丁美洲人（尤其是墨西哥裔美国人），包括对AD及其临床的认识功能，关注AD和护理燃烧后果的关注程度以及愿意参加研究包括生物标志物，遗传学和尸检的程序。解决这些需求，拉丁裔核心的总体目标是：1）进行语言和文化的记忆在圣地亚哥主要是拉丁裔地区的筛查和评估计划，以发展和维护对研究感兴趣并同意成为的良好表征的老年拉丁裔人的注册表有关正在进行的广告相关研究的联系； 2）进行发展研究以完善和评估语言和文化适当的临床和认知评估程序，以准确确定MCI和向较老的拉丁裔痴呆症的过渡； 3）进行发展研究确定知识程度并参加广告，大脑健康以及参与广告的各个方面较老的拉丁裔研究； 4）充当ADRC活动与大规模活动之间的管道关于旧拉丁裔认知变化的流行病学项目，称为拉丁美洲人的研究研究神经认知衰老（SOL-INCA）以及其他新的国家和全州拉丁裔研究计划。这会允许识别出可能的轻度认知障碍或ADRD的参与者获得更广泛的临床以及神经心理学的特征并参与广告相关的研究项目，包括临床试验。这，拉丁裔核心将确保ADRC能够在这一重要的服务欠佳的人群，填补了科学知识的关键空白对于减少与分布相关的分布至关重要在我们的圣地亚哥社区及其他地区，拉丁美洲人面临的诊断，治疗和护理。