Latino

拉丁裔

• 批准号: 10407985
• 负责人: Tamar Gollan
• 金额: $ 22.6万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407985
• 关键词: Address; African American population; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Attitude; Autopsy; Awareness; Behavioral; Biological Markers; Birth; Brain; California; Cardiovascular system; Caring; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Cognition; Cognitive; Communities; County; Data Set; Databases; Dementia; Development; Diagnosis; Disease; Early Diagnosis; Early treatment; Education; Effectiveness; Elderly; Enrollment; Ensure; Environment; Epidemiology; Exposure to; Eye; General Practitioners; Genetic; Health; Healthcare; Hispanic; Insurance; Investigation; Knowledge; Language; Latino; Latino Population; Life Expectancy; Linguistics; Memory; Metabolic; Methods; Mexican Americans; Names; Neurocognitive; Neurologic; Neuropsychology; Participant; Patients; Persons; Physicians; Population; Positioning Attribute; Procedures; Program Evaluation; Reduce health disparities; Registries; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Role; Sampling; Screening procedure; Services; Spinal Puncture; Study of Latinos; Subgroup; Testing; Underserved Population; United States National Institutes of Health; Validation; Work; age related; base; bilingualism; brain health; burden of illness; care burden; caucasian American; clinical center; clinical outcome measures; cognitive change; cognitive testing; cohort; diagnostic tool; disparity reduction; education research; health disparity; innovation; interest; mild cognitive impairment; neuroimaging; novel; outreach; pre-clinical; ranpirnase; recruit; research study; screening; social disadvantage; tool; willingness

LATINO CORE - SUMMARY/ ABSTRACT Alzheimer’s disease and related dementias (ADRD) among U.S. Latinos are projected to increase over nine-fold from 379,000 in 2012 to 3.5 million by 2060. Latinos represent 18% of the U.S. population and about 40% of the population of California. Latinos lag behind Whites and African-Americans in education and healthcare insurance, and have cardiovascular, metabolic, and other disease burdens that exceed those of Whites; however, Latino life-expectancy at birth surpasses that of Whites by over 3-years giving them greater exposure to age-related risk of ADRD. Because of these factors, and cultural differences in reporting behavioral, cognitive, and functional deficits, state-of-the-art clinical, neuropsychological, and neurological procedures used to diagnose AD, that were largely developed and validated in relatively homogeneous, well- educated, White, English-speaking populations, may not work effectively with monolingual Spanish-speaking or Spanish-English bilingual older Latinos. Thus, there is a need for AD-related research in older Latinos to overcome barriers to effective screening, assessment, diagnosis and treatment of early and preclinical disease. There is also a need to better understand factors that impede or facilitate participation of elderly Latinos (particularly Mexican-Americans) in AD-related research, including awareness of AD and its clinical features, level of concern about the consequences of AD and burden of care, and willingness to participate in research including procedures such as sampling of biomarkers, genetics, and autopsy. To address these needs, the overall aims of the Latino Core are to: 1) conduct a linguistically- and culturally-appropriate memory screening and evaluation program in predominantly Latino areas in San Diego to develop and maintain a registry of well-characterized older Latino individuals who are interested in research and have agreed to be contacted about on-going AD-related research studies; 2) conduct developmental research to refine and evaluate linguistically- and culturally-appropriate clinical and cognitive assessment procedures to accurately identify MCI and the transition to AD dementia in older Latinos; 3) conduct developmental research to determine degree of knowledge and attitudes towards AD, brain health, and participation in all aspects of AD research in older Latinos; and 4) serve as a conduit between the activities of the ADRC and a large-scale epidemiology project on cognitive changes in older Latinos known as the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) and other new national and state-wide Latino research initiatives. This will allow participants identified with possible Mild Cognitive Impairment or ADRD to receive more extensive clinical and neuropsychological characterization and to participate in AD-related research projects, including clinical trials. Thus, the Latino Core will ensure that the ADRC is well positioned to study ADRD in this significant yet underserved population, filling critical gaps in scientific knowledge essential for reducing the disparities related to ADRD diagnosis, treatment and care facing Latinos in our San Diego community and beyond.

拉丁核心-总结/摘要 阿尔茨海默病和相关痴呆症（ADRD）在美国拉丁美洲人中预计将增加， 从2012年的379，000人增加到2060年的350万人。拉丁裔占美国人口的18%， 占加州人口的40%。拉丁裔在教育方面落后于白人和非洲裔美国人， 医疗保险，心血管，代谢和其他疾病的负担超过那些 白人;然而，拉丁美洲人出生时的预期寿命超过白人3年，使他们更大 暴露于ADRD的年龄相关风险。由于这些因素和文化差异的报道 行为、认知和功能缺陷，最先进的临床、神经心理学和神经学 用于诊断AD的程序，在很大程度上是在相对同质的，良好的， 受过教育的，白色，讲英语的人口，可能无法有效地与单语西班牙语 或西班牙语-英语双语的老年拉丁裔。因此，有必要在老年拉丁美洲人中进行AD相关研究， 克服早期和临床前有效筛查、评估、诊断和治疗的障碍 疾病还需要更好地了解阻碍或促进老年人参与的因素 拉丁美洲人（特别是墨西哥裔美国人）参与AD相关研究，包括对AD的认识及其临床 特征、对AD后果和护理负担的关注程度以及参与 研究包括生物标志物取样、遗传学和尸检等程序。解决这些 需要，拉丁美洲核心的总体目标是：1）进行语言和文化适当的记忆 在圣地亚哥以拉丁裔为主的地区开展筛查和评估计划，以制定和维护 登记册的特点老年拉丁美洲人谁有兴趣在研究，并已同意 联系正在进行的AD相关研究; 2）进行发展研究， 评估语言和文化上适当的临床和认知评估程序， 确定MCI和老年拉丁美洲人向AD痴呆的转变; 3）进行发展研究， 确定对AD的知识和态度、大脑健康以及参与AD各个方面的程度 在老年拉丁美洲人的研究;和4）作为ADRC的活动和大规模的活动之间的管道 关于老年拉丁裔认知变化的流行病学项目，称为拉丁裔研究-调查 神经认知老化（SOL-INCA）和其他新的国家和全州范围的拉丁美洲研究计划。这将 允许识别为可能的轻度认知障碍或ADRD的参与者接受更广泛的临床治疗， 和神经心理学表征并参与AD相关研究项目，包括临床 审判因此，拉丁裔核心将确保ADRC能够在这个重要的时期研究ADRD。 填补科学知识方面的重大空白，这对于缩小与贫困人口相关的 ADRD诊断，治疗和护理面临拉丁美洲人在我们的圣地亚哥社区和超越。