State of the Art 3T Research Scanner

最先进的 3T 研究扫描仪

• 批准号: 9075657
• 负责人: Peter CM Van Zijl
• 金额: $ 199.9万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2018-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9075657
• 关键词: Address; Algorithms; Behavior; Computers; Detection; Developmental Disabilities; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Frequencies; Functional Magnetic Resonance Imaging; Funding; Future; Grant; Head and neck structure; Human; Image; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Motion; Noise; Physiologic pulse; Physiological; Process; Research; Research Institute; Research Personnel; Resolution; Scanning; Signal Transduction; Slice; System; Time; United States National Institutes of Health; Universities; connectome; diffusion weighted; digital; end of life; improved; magnetic field; prisma; radiofrequency; reconstruction; spectrograph; spectroscopic imaging

 DESCRIPTION (provided by applicant): We propose to purchase a state of the art 3T MRI scanner (Siemens MAGNETOM Prisma) in order to replace our end-of-life 3 Tesla Philips research scanner at the F.M. Kirby Research Center of the Hugo Moser Research Institute at Kennedy Krieger (KKI), which cannot be upgraded to the newest digital Philips Achieva system. This scanner replacement is necessary to address the needs of many investigators at the KKI and Johns Hopkins University (JHU) who have 15 NIH-funded grants with specific aims that strongly benefit from the improved technical capabilities provided by this upgrade. These investigators use the 3T system for structural MRI, functional MRI (fMRI), quantitative physiological MRI, magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI), and diffusion tensor imaging (DTI) for the study of human behavior and a large range of diseases and developmental disabilities. The main features of importance for us on the Prisma are availability of 1) magnetic field gradient hardware with the highest simultaneous strength (80 mT/m) and slew rate (200 mT/m/s), 2) a completely digital radiofrequency (RF) transmit/receive system with 3) 128 receive channels; 4) a 64-channel head and neck coil; 5) improved field and frequency stability; 6) availability of advanced simultaneous multi-slice (SMS) and multiband (MB) packages both from Siemens and from advanced Siemens users leading the human connectome project (HCP); 7) we will have the fastest reconstruction computer available on an MRI scanner with full user control. This scanner will provide a large range of benefits for our users, including but not limited to: improved signal to noise ratio (SNR) for all applications due o reduced noise in the digital receive system, which can be used for better detection of small signals, finer spatial resolution, and/or faster scans. SNR is further increased for DTI scans due to shorter echo time (TE) attainable with higher gradient strength (shorter diffusion time) and slew rate (shorter readout time). The availability of 128 receive channels provides a future path to high-end "connectome-type" RF hardware. The first commercially available 64-channel coil is expected to provide modestly improved SNR compared to 32-channel as well as an improved g-factor for parallel imaging, especially for controlled aliasing in SMS/MB imaging. Improved frequency stability compared to our current system will provide benefits for a) improved signal intensity stability for dynamic scans; b) absence of spatial image drift under high duty cycle gradient use such as in diffusion spectrum imaging (DSI) with many orientations and strong diffusion weighting; c) improved spectral editing with selective pulse excitation; d) improved CEST-MRI frequency referencing. Finally, user control of the reconstruction computer allows on- scanner processing of HCP-type acquisition sequences and real-time motion-correction algorithms.

 描述（由申请人提供）：我们建议购买一台最先进的 3T MRI 扫描仪（西门子 MAGNETOM Prisma），以替换 F.M. 的报废 3 Tesla Philips 研究扫描仪。肯尼迪克里格 (KKI) 雨果·莫泽研究所的柯比研究中心无法升级到最新的数字飞利浦 Achieva 系统。此次扫描仪更换对于满足 KKI 和约翰·霍普金斯大学 (JHU) 的许多研究人员的需求是必要的，这些研究人员拥有 15 项 NIH 资助的赠款，这些赠款的具体目的是从此次升级提供的改进的技术能力中受益匪浅。这些研究人员使用 3T 系统进行结构 MRI、功能 MRI (fMRI)、定量生理 MRI、磁共振波谱 (MRS) 和光谱成像 (MRSI) 以及扩散张量成像 (DTI)，以研究人类行为以及多种疾病和发育障碍。 Prisma 的主要特点是：1) 具有最高同步强度 (80 mT/m) 和转换速率 (200 mT/m/s) 的磁场梯度硬件，2) 具有 3) 128 个接收通道的全数字射频 (RF) 发射/接收系统； 4）64通道头颈线圈； 5) improved field and frequency stability; 6) 西门子和领导人类连接组项目 (HCP) 的高级西门子用户提供先进的同步多切片 (SMS) 和多频带 (MB) 软件包； 7) 我们将拥有 MRI 扫描仪上最快的重建计算机，并具有完全的用户控制能力。 该扫描仪将为我们的用户提供一系列好处，包括但不限于：由于数字接收系统中的噪声降低，所有应用的信噪比 (SNR) 得到改善，可用于更好地检测小信号、更精细的空间分辨率和/或更快的扫描。由于更高的梯度强度（更短的扩散时间）和转换速率（更短的读出时间）可实现更短的回波时间 (TE)，因此 DTI 扫描的 SNR 进一步增加。 128 个接收通道的可用性为未来的高端“连接组型”射频硬件提供了一条途径。与 32 通道相比，第一个商用 64 通道线圈预计将提供适度改进的 SNR，并为并行成像提供改进的 g 因子，特别是对于 SMS/MB 成像中的受控混叠。与我们当前的系统相比，改进的频率稳定性将带来以下好处：a) 改进动态扫描的信号强度稳定性； b) 在高占空比梯度使用下不存在空间图像漂移，例如在具有多个方向和强扩散加权的扩散光谱成像（DSI）中； c) 通过选择性脉冲激发改进光谱编辑； d) 改进了 CEST-MRI 频率参考。最后，用户对重建计算机的控制允许在扫描仪上处理 HCP 型采集序列和实时运动校正算法。