Molecular Biology and Genetics Program

分子生物学和遗传学计划

• 批准号: 9071324
• 负责人: KAREN E KNUDSEN
• 金额: $ 3.09万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9071324
• 关键词: Biochemistry; Biology; Cancer Center; Cancer Patient; Cell Proliferation; Cells; Collaborations; Diagnosis; Faculty; Gene Expression Regulation; Gene Targeting; Genes; Genetic Programming; Genetic Transcription; Goals; Grant; Hematologic Neoplasms; Immunity; Influentials; Institutes; Journals; Malignant Neoplasms; Medical Research; Molecular; Molecular Biology; Molecular Genetics; Nature; Normal Cell; Oncogenes; Paper; Peer Review; Peer Review Grants; Postdoctoral Fellow; Prevention therapy; Process; Publications; Publishing; Solid Neoplasm; Testing; Training; Transcriptional Regulation; Translating; Translational Research; Tumor Markers; Universities; base; cancer diagnosis; cancer prevention; cell growth; cost; design; gene discovery; gene function; graduate student; improved; interest; meetings; member; mouse model; neoplastic cell; novel; novel diagnostics; novel therapeutic intervention; personalized medicine; prognostic; programs; targeted treatment; tumor; tumorigenesis

Program 2, the Molecular Biology and Genetics of Cancer Program (MBG), integrates fundamental studies in the control of gene transcription and regulation with the genetic and molecular mechanisms underlying the most common types of solid tumors and hematological malignancies. An integral part of the KCC since 1991, this program focuses on gene discovery and gene function analyses in order to exploit the translational potential of these studies for cancer diagnosis, assessment, prevention and therapy. The long-term goal of this program is to discover information useful in designing "personalized therapies" for cancer patients. The Molecular Biology and Genetics of Cancer Program brings together 22 faculty members from 10 academic departments (including the Lankenau Institute for Medical Research and the Department of Biochemistry and Molecular Biology of Drexel University) who are supported by NCI ($3.25 million total costs) and other peer-reviewed grants ($7.80 million total costs). Many members of this program have made important discoveries that have been translated into improved cancer diagnosis and assessment, and into novel therapeutic approaches. In the last five years, program members have continued to interact productively, publishing approximately 100 papers/year in some of the best known and more influential journals such as Nature, Mol.Cell, J.Clin.Invest., Immunity, PNAS. Of papers published since 2007, 21.0% have been the result of intra-programmatic collaborations and 31.3% the result of inter-programmatic collaborations. The program has 15-20 graduate students and more than 80 postdoctoral fellows. Their training and the interactions, both intra- and inter-programmatic, among all members are supported by monthly meetings that enhance the program's translational focus.

计划2，癌症分子生物学和遗传学计划（MBG），整合了基础研究， 基因转录和调控的控制与遗传和分子机制的基础， 最常见类型的实体瘤和血液恶性肿瘤。自1991年以来一直是KCC的组成部分， 该计划的重点是基因发现和基因功能分析，以利用翻译 这些研究在癌症诊断、评估、预防和治疗方面的潜力。的长期目标 这个项目是为了发现对癌症病人设计“个性化治疗”有用的信息。的 分子生物学和癌症遗传学项目汇集了来自10个学术机构的22名教员 部门（包括兰克瑙医学研究所和生物化学系， 德雷克塞尔大学的分子生物学），由NCI（总费用为325万美元）和其他同行评审 赠款（总费用780万美元）。这个计划的许多成员都有重要的发现 已经转化为改进的癌症诊断和评估，并转化为新的治疗方法， 接近。在过去的五年里，项目成员继续进行富有成效的互动， 每年在一些最知名和最有影响力的期刊上发表约100篇论文，如《自然》， Mol.Cell，J.Clin.Invest.，豁免权PNAS自2007年以来发表的论文中，21.0%是由于 31.3%是方案内合作的结果，31.3%是方案间合作的结果。程序 现有研究生15-20人，博士后80余人。他们的训练和互动， 所有成员之间的方案内和方案间工作得到每月会议的支持， 项目的翻译重点。