Translational Research

转化研究

• 批准号: 9071331
• 负责人: KAREN E KNUDSEN
• 金额: $ 24.62万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9071331
• 关键词: Adopted; Applications Grants; Archives; Basic Science; Biological Assay; Biological Markers; Biological Preservation; Blood; Body Fluids; Cancer Center; Clinical; Clinical Data; Clinical Pathology; Clinical Research; DNA; Data; Databases; Development; Equipment; Evaluation; Excision; Experimental Animal Model; Faculty; Funding; Goals; Growth; Histocompatibility Testing; Histology; Human; Image Analysis; Improve Access; In Situ; Individual; Information Systems; Instruction; Ischemia; Laboratories; Lasers; Location; London; Malignant Neoplasms; Microdissection; Mission; Molecular Analysis; Online Systems; Operative Surgical Procedures; Paraffin; Pathology; Patients; Preparation; Principal Investigator; Procedures; Process; Publications; Quality Control; RNA; Research; Research Personnel; Resource Sharing; Resources; Services; Slide; Specimen; Staining method; Stains; Surgical Pathology; System; Time; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Tumor Bank; Tumor Tissue; University Hospitals; Update; base; benefit sharing; cell type; human tissue; improved; innovation; member; neoplastic; neurosurgery; next generation sequencing; novel marker; patient subsets; programs; sample collection; targeted treatment; time interval; tissue processing; tissue resource; trial design

PROJECT SUMMARY (See instructions): Since the inception of the Translational Research Shared Resource its mission has been to provide tissue processing, slide preparation, histochemical staining, and immunohistochemical staining for human neoplastic tissue and experimental animal model tissue being utilized by KCC researchers. This shared resource has also provided procurement, banking and distribution of human neoplastic tissue in order to facilitate translational research. The caBlG caTissue biospecimen management application has been used by tissue bankers since 2007 to enter clinical and pathogical specimen annotation, as well as track specimen storage and distribution. This biospecimen database integrates access to 7 campus specimen collections having about 440,000 specimens from 170,000 individuals. In addition, the Translational Research Shared Resource provides tissue microarrays construction service with paraffin archive material from the resource tumor/tissue bank. Laser microdissection of distinct cell and tissue types for molecular analysis can be performed on the resource's Laser Microdissection system. For all of the capabilities offered by the Translational Research Shared Resource, staff is available to provide technical support and pathology expertise to KCC investigators. Between 2008 and 2011 23 principal investigators from all programs of the KCC benefited from this shared resource.

项目摘要（参见说明）： 自转化研究共享资源成立以来，其使命一直是为 KCC 研究人员使用的人类肿瘤组织和实验动物模型组织提供组织处理、玻片制备、组织化学染色和免疫组织化学染色。这一共享资源还提供人类肿瘤组织的采购、储存和分配，以促进转化研究。自 2007 年以来，caBlG caTissue 生物样本管理应用程序已被组织库人员用于输入临床和​​病理样本注释，以及跟踪样本存储和分发。该生物样本数据库集成了对 7 个校园样本库的访问，其中包含来自 170,000 个人的约 440,000 个样本。此外，转化研究共享资源利用来自肿瘤/组织库的石蜡档案材料提供组织微阵列构建服务。可以在资源的激光显微切割系统上对不同细胞和组织类型进行激光显微切割以进行分子分析。对于所有的能力 通过转化研究共享资源，工作人员可以为 KCC 研究人员提供技术支持和病理学专业知识。 2008 年至 2011 年间，KCC 所有项目的 23 名主要研究人员受益于这一共享资源。