Bioinformatics

生物信息学

• 批准号: 9071334
• 负责人: KAREN E KNUDSEN
• 金额: $ 12.31万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9071334
• 关键词: Bioinformatics; Bioinformatics Shared Resource; Biomedical Research; Biometry; Cancer Center; Cancer Patient; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Hospitals; Complement; Computer software; Computers; Consultations; Contracts; Core Facility; Data; Data Analyses; Databases; Disasters; Equipment; Funding; Generations; Grant; Health Insurance Portability and Accountability Act; Individual; Informatics; Information Technology; Instruction; Malignant Neoplasms; Mining; Mission; NCI Center for Cancer Research; Operations Research; Pathology; Peer Review; Privacy; Publications; Recovery; Regulation; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Reservations; Resource Informatics; Resource Sharing; Resources; Security; Services; Specimen; System; Technology; Tissue Banking; Tissue Banks; Translational Research; United States National Institutes of Health; Universities; anticancer research; biomedical informatics; cancer genomics; cohort; common rule; data management; direct application; human subject; informatics shared resource; interest; interoperability; member; neoplasm registry; operation; programs; repository; software development; tool; tumor registry; web site

PROJECT SUMMARY (See instructions): The Informatics Shared Resource (ISR) serves as a biomedical research informatics resource for KCC's basic, clinical, and translational investigators. This support includes infrastructure! provisioning, software development or acquisition, and consultative collaboration. ISR services are available directly to peer reviewed funded cancer investigators, or indirectly to other cancer center core facilities, thereby providing services to all program members. The ISR also provides informatics support for the clinical research activities of the Jefferson Kimmel Cancer Center Network of community hospitals. More specifically, the ISR supports cancer center research by developing and/or deploying: 1) Clinical trials applications to give clinical researchers the tools to manage clinical trials data, including mandated reporting. 2) Biospecimen repository applications to help tissue bank staff manage specimen accessioning and distribution, and provide investigators with an ordering mechanism and information characterizing specimens available for research. 3) Data warehousing and mining applications to provide cancer researchers with a research data mart that integrates clinical, biospecimen, cancer registry, clinical trials, and experimental data for cohort identification and hypothesis generation. 4) Infrastructure and applications for other KCC shared resources to facilitate access to their services. The ISR thus provides KCC investigators with ready access to integrated comprehensive information on clinical trials, cancer patients, and research specimens, as well as providing a single portal for requesting equipment and services from KCC shared resources. In all its activities, the ISR recognizes interoperability as crucial to the sharing of research data and resources to promote efficient cancer research, and utilizes standards articulated by the NCI and the biomedical informatics community. Software applications are hosted on servers with networked storage located at a commercial data center contracted by the University, providing professional data center security and disaster recovery services. The ISR employs best practices with regard to data privacy and security complying with the Common Rule, HIPAA, and state regulations.

项目总结(见说明)： 信息学共享资源(ISR)为KCC的基础、临床和翻译研究人员提供生物医学研究信息学资源。这种支持包括基础设施！资源调配、软件开发或采购以及咨询协作。ISR服务可直接提供给同行评审资助的癌症研究人员，或间接提供给其他癌症中心核心设施，从而为所有计划成员提供服务。ISR还为杰斐逊·基梅尔癌症中心社区医院网络的临床研究活动提供信息学支持。更具体地说，ISR通过开发和/或部署以下内容来支持癌症中心研究： 1)临床试验应用程序，为临床研究人员提供管理临床试验数据的工具，包括强制报告。 2)Biospecimen数据库应用程序，帮助组织库工作人员管理标本的加入和分发，并为研究人员提供可用于研究的标本排序机制和表征标本的信息。 3)数据仓库和挖掘应用，为癌症研究人员提供一个研究数据集市，该数据集市集成了临床、生物医学、癌症登记、临床试验和实验数据，用于队列识别和假设生成。4)其他KCC共享资源的基础设施和应用程序，以方便访问其服务。 因此，ISR为KCC研究人员提供了随时访问有关临床试验、癌症患者和研究标本的综合综合信息的途径，并提供了从KCC共享资源请求设备和服务的单一门户。在其所有活动中，ISR认识到互操作性对于共享研究数据和资源以促进有效的癌症研究至关重要，并利用NCI和生物医学信息学社区阐明的标准。软件应用程序托管在具有网络存储的服务器上，该服务器位于大学签约的商业数据中心，提供专业的数据中心安全和灾难恢复服务。ISR采用符合共同规则、HIPAA和州法规的数据隐私和安全方面的最佳做法。