Cancer Cell Biology and Signaling

项目总结(见说明)： 癌症细胞生物学与信号计划(CCBS)的使命是阐明细胞信号在调节细胞生长、分化、凋亡和迁移中的作用，并协助癌症中心成员努力将这一认识运用到癌症检测、预后和治疗的方法中。项目成员专注于三个主要领域的研究：1)了解参与细胞生长和分化调控的分子机制，重点是酪氨酸激酶和G蛋白偶联受体信号通路的作用；2)阐明调控细胞凋亡的分子机制；3)阐述细胞外基质在调控细胞生长和迁移中的作用。 该计划由Jeffrey Benovic博士和George Prendergast博士领导，他们两人都有丰富的管理经验，并建立了专注于细胞信号和癌症的研究计划。 该方案由来自9个部门和3个机构(杰斐逊、兰克瑙医学研究所和德雷克塞尔)的23名成员和1名准成员组成。计划成员目前拥有340万美元的NCI支持和1200万美元的同行评审支持，并在上一次资助期间共发表了650篇手稿(11%是计划内的，26%是计划间的)。

PROJECT SUMMARY (See instructions): The mission of the Cancer Cell Biology and Signaling (CCBS) Program is to elucidate the role of cell signaling in regulating cell growth, differentiation, apoptosis and migration, and to assist Cancer Center members in their efforts to harness this understanding into approaches to cancer detection, prognosis and treatment. Program members focus on three major areas of research: 1) understanding the molecular mechanisms involved in the regulation of cell growth and differentiation with an emphasis on the role of tyrosine kinase and G protein-coupled receptor signaling pathways; 2) elucidating the molecular mechanisms regulating cell apoptosis; and 3) addressing the role of the extracellular matrix in regulating cell growth and migration. The Program is led by Drs. Jeffrey Benovic and George Prendergast, both of whom have extensive administrative experience and established research programs focused on cell signaling and cancer. The Program is comprised of twenty-three members and one associate member from nine departments and three Institutions (Jefferson, Lankenau Institute for Medical Research and Drexel). Program members currently have $3.4 million of NCI support and $12.0 million of total, peer-reviewed support and have published a total of 650 manuscripts (11% intra-programmatic and 26% inter-programmatic) during the last funding period.