Cycles of Social Contingency in Autism: Pivotal Transitions that Shape Infant Brain-Behavior Development in Human & Model Systems

自闭症的社会偶然性循环：塑造人类婴儿大脑行为发育的关键转变

• 批准号: 10005469
• 负责人: AMI KLIN
• 金额: $ 218.76万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005469
• 关键词: Accounting; Achievement; Address; Affect; Age; Age-Months; Attenuated; Behavior; Behavioral; Biological; Biological Models; Birth; Brain; Caregivers; Characteristics; Child; Child Development; Clinical Sciences; Clinical Treatment; Clinical assessments; Communication; Communities; Community Outreach; Data; Development; Early Intervention; Early treatment; Environment; Etiology; Family; Future; Genes; Genetic Predisposition to Disease; Genetic Risk; Goals; Growth; Healthcare Systems; Human; Individual; Individual Differences; Infant; Informatics; Institution; Intellectual functioning disability; Intervention; Laboratories; Language; Learning; Letters; Life; Macaca mulatta; Mainstreaming; Measures; Mediator of activation protein; Methodology; Methods; Mission; Modality; Modeling; Monkeys; National Institute of Mental Health; Neurobiology; Neurosciences Research; Outcome; Postdoctoral Fellow; Prediction of Response to Therapy; Randomized Controlled Trials; Research; Research Priority; Resources; Sampling; Science; Scientist; Series; Shapes; Signal Detection Analysis; Social Development; Social Interaction; Speech; Structure; Sum; Symptoms; System; Techniques; Technology; Testing; Toddler; Translational Research; Treatment outcome; Universities; Visual; Work; autism spectrum disorder; autistic children; base; behavioral study; brain behavior; child services; clinical care; clinical center; cohort; disability; evidence base; expectation; functional outcomes; health care delivery; high risk; implementation science; infancy; innovation; next generation; nonhuman primate; outreach; predictive test; programs; prospective; response; social; social communication; social engagement; social neuroscience; symptomatology; tool; treatment effect; treatment optimization; treatment research; treatment strategy

PROJECT SUMMARY The Emory ACE joins 12 laboratories in 6 institutions under the auspices of Emory University, creating a center for clinical and translational science built – from its outset – on the expectation of transformative impact on the community. These laboratories combine methodological and conceptual expertise in child development, speech science, behavioral neuroscience, and treatment research. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to execute science that leads directly to a future of optimized outcomes for the next generations of children with autism spectrum disorder (ASD). Projects I-III study reciprocal behavior, in the visual and vocal, brain and behavior domains, within the first six months of life, and in subsequent brain-behavior transitions until 30 months of age, in infants and toddlers at low and high risk for ASD. Project IV advances rigorous, randomized-controlled trials for treatment of ASD into infancy and toddlerhood, testing infant and infant- caregiver characteristics that predict treatment response and outcome; its goal is to optimize treatment effects, personalized to the developmental stage of the child, and within the structure of the child-caregiver dyad. Project V advances a nonhuman primate model of social development, interrogating the underpinnings of social disability in brain and behavior studies. Together, these Projects advance our understanding of the developmental unfolding of ASD, and sets the stage for changing its course prior to the point when disability is even fully manifest. Four Cores provide the resources to support these goals, spanning Clinical Assessment and Care, Informatics, Administration and Dissemination & Outreach. In its efforts to meet and exceed the aspirational goals for autism set forth by the US DHSS Interagency Autism Coordinating Committee and by NIMH Research Priorities, the Emory ACE expands a new scientific community, focused on the translational social neuroscience of ASD, in service of children and families. Its ultimate goal is to change the narrative of ASD from one of potentially devastating disability to one of positive diversity, in which individuals with autism are able to succeed despite their learning differences and because of their unique assets, unencumbered by the burdens of language, intellectual disabilities, and severe behavior challenges.

项目摘要 埃默里（Emory Ace）在埃默里大学（Emory University）的主持下加入了6个机构的12个实验室，创建了一个中心 从一开始，临床和翻译的科学就对变革性影响的期望 社区。这些实验室结合了儿童发展中的方法论和概念专业知识，语音 科学，行为神经科学和治疗研究。 Emory Ace的主题使命指导 在其5个项目和4个核心中：执行科学直接导致下一个优化结果的未来 几代自闭症谱系障碍（ASD）的儿童。在视觉上项目I-III研究相互行为 在生命的前六个月内以及随后的大脑行为，大脑和行为领域和人声，大脑和行为领域 过渡到30个月大，在ASD低和高风险的婴儿和幼儿中。项目IV进步 严格的，随机控制的试验，用于将ASD治疗为婴儿期和幼儿，对婴儿和婴儿进行测试 护理人员的特征可以预测治疗反应和结果；它的目标是优化治疗效果， 个性化到孩子的发育阶段，以及在儿童保育员二元组的结构内。项目 V促进了社会发展的非人类私人模型，审问了社会残疾的基础 在大脑和行为研究中。这些项目共同提高了我们对发展的理解 ASD的展开，为在残疾完全表现出来之前改变其课程奠定了基础。 四个核心提供了支持这些目标的资源，涵盖临床评估和护理，信息学， 行政和传播与宣传。为了实现并超越自闭症的理想目标 美国国土安全部跨机构自闭症协调委员会和NIMH研究优先事项提出的 Emory Ace扩大了一个新的科学界，专注于ASD翻译的社会神经科学， 服务儿童和家庭。它的最终目标是将ASD的叙述从潜在的一种 毁灭性的残疾对一种积极的多样性之一，自闭症患者能够成功目的地 他们的学习差异和由于其独特的资产，不受语言的伯伦斯的束缚， 智力残疾和严重的行为挑战。