Cycles of Social Contingency in Autism: Pivotal Transitions that Shape Infant Brain-Behavior Development in Human & Model Systems

自闭症的社会偶然性循环：塑造人类婴儿大脑行为发育的关键转变

• 批准号: 10005469
• 负责人: AMI KLIN
• 金额: $ 218.76万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005469
• 关键词: Accounting; Achievement; Address; Affect; Age; Age-Months; Attenuated; Behavior; Behavioral; Biological; Biological Models; Birth; Brain; Caregivers; Characteristics; Child; Child Development; Clinical Sciences; Clinical Treatment; Clinical assessments; Communication; Communities; Community Outreach; Data; Development; Early Intervention; Early treatment; Environment; Etiology; Family; Future; Genes; Genetic Predisposition to Disease; Genetic Risk; Goals; Growth; Healthcare Systems; Human; Individual; Individual Differences; Infant; Informatics; Institution; Intellectual functioning disability; Intervention; Laboratories; Language; Learning; Letters; Life; Macaca mulatta; Mainstreaming; Measures; Mediator of activation protein; Methodology; Methods; Mission; Modality; Modeling; Monkeys; National Institute of Mental Health; Neurobiology; Neurosciences Research; Outcome; Postdoctoral Fellow; Prediction of Response to Therapy; Randomized Controlled Trials; Research; Research Priority; Resources; Sampling; Science; Scientist; Series; Shapes; Signal Detection Analysis; Social Development; Social Interaction; Speech; Structure; Sum; Symptoms; System; Techniques; Technology; Testing; Toddler; Translational Research; Treatment outcome; Universities; Visual; Work; autism spectrum disorder; autistic children; base; behavioral study; brain behavior; child services; clinical care; clinical center; cohort; disability; evidence base; expectation; functional outcomes; health care delivery; high risk; implementation science; infancy; innovation; next generation; nonhuman primate; outreach; predictive test; programs; prospective; response; social; social communication; social engagement; social neuroscience; symptomatology; tool; treatment effect; treatment optimization; treatment research; treatment strategy

PROJECT SUMMARY The Emory ACE joins 12 laboratories in 6 institutions under the auspices of Emory University, creating a center for clinical and translational science built – from its outset – on the expectation of transformative impact on the community. These laboratories combine methodological and conceptual expertise in child development, speech science, behavioral neuroscience, and treatment research. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to execute science that leads directly to a future of optimized outcomes for the next generations of children with autism spectrum disorder (ASD). Projects I-III study reciprocal behavior, in the visual and vocal, brain and behavior domains, within the first six months of life, and in subsequent brain-behavior transitions until 30 months of age, in infants and toddlers at low and high risk for ASD. Project IV advances rigorous, randomized-controlled trials for treatment of ASD into infancy and toddlerhood, testing infant and infant- caregiver characteristics that predict treatment response and outcome; its goal is to optimize treatment effects, personalized to the developmental stage of the child, and within the structure of the child-caregiver dyad. Project V advances a nonhuman primate model of social development, interrogating the underpinnings of social disability in brain and behavior studies. Together, these Projects advance our understanding of the developmental unfolding of ASD, and sets the stage for changing its course prior to the point when disability is even fully manifest. Four Cores provide the resources to support these goals, spanning Clinical Assessment and Care, Informatics, Administration and Dissemination & Outreach. In its efforts to meet and exceed the aspirational goals for autism set forth by the US DHSS Interagency Autism Coordinating Committee and by NIMH Research Priorities, the Emory ACE expands a new scientific community, focused on the translational social neuroscience of ASD, in service of children and families. Its ultimate goal is to change the narrative of ASD from one of potentially devastating disability to one of positive diversity, in which individuals with autism are able to succeed despite their learning differences and because of their unique assets, unencumbered by the burdens of language, intellectual disabilities, and severe behavior challenges.

项目摘要 埃默里ACE加入了埃默里大学赞助下的6个机构的12个实验室， 从一开始，临床和转化科学就建立在对 社区这些实验室结合了联合收割机在儿童发展、言语、 行为神经科学和治疗研究。埃默里ACE的主题使命指导每个 它的5个项目和4个核心：执行科学，直接导致未来的优化成果， 自闭症谱系障碍（ASD）的儿童。项目I-III研究互惠行为，在视觉上， 以及发声、大脑和行为领域，在生命的前六个月内，以及随后的大脑行为中， 在ASD低风险和高风险的婴儿和幼儿中，过渡到30个月大。项目四预付款 严格的，随机对照试验，用于治疗ASD到婴儿和幼儿期，测试婴儿和婴儿- 预测治疗反应和结果的护理人员特征;其目标是优化治疗效果， 根据儿童的发育阶段，在儿童-照顾者二元结构内进行个性化。项目 第五章提出了一个非人类灵长类动物的社会发展模型，质疑社会残疾的基础 在大脑和行为研究中。总之，这些项目促进了我们对发展的理解， 这是一个关于自闭症的故事，在自闭症完全显现之前，它就已经改变了它的进程。 四个核心提供支持这些目标的资源，涵盖临床评估和护理，信息学， 行政管理和传播与外联。在努力实现并超越自闭症的理想目标的过程中， 由美国卫生和社会保障部机构间自闭症协调委员会和NIMH研究优先事项提出， 埃默里ACE扩展了一个新的科学社区，专注于ASD的转化社会神经科学， 儿童和家庭服务。它的最终目标是改变ASD的叙述， 毁灭性的残疾，积极的多样性之一，其中自闭症患者能够成功，尽管 他们的学习差异，由于他们独特的资产，不受语言负担的影响， 智力障碍和严重的行为障碍。