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Error Detection and Error Awareness in Incarcerated Cocaine Dependent Individuals

被监禁的可卡因依赖者的错误检测和错误意识

基本信息

批准号：
8677836
负责人：
Matthew Shane
金额：
$ 35.42万
依托单位：
THE MIND RESEARCH NETWORK
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-15 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8677836
关键词：
Abstinence Adult Alcohol or Other Drugs use Anterior Attention Awareness Behavior Behavioral Characteristics Chronic Clinical Research Cocaine Cocaine Abuse Cognitive Comorbidity Conflict (Psychology)Conscious Cues Data Dependency Detection Development Diagnosis Disease Drug usage Epidemiologic Studies Equilibrium Error Sources Evaluation Evaluation Indexes Exertion Feedback Female Frequencies Functional Magnetic Resonance Imaging Functional disorder Future General Population Goals Gray unit of radiation dose Human Image Impairment Imprisonment Individual Investigation Laboratories Lead Learning Link Literature Magnetic Resonance Imaging Mental disorders Methods Mind-Body Method Mission Modeling Monitor Nature Neurocognitive New Mexico Nucleus Accumbens Participant Pattern Performance Personal Satisfaction Pharmaceutical Preparations Play Population Preparation Prevalence Process Punishment Regression Analysis Regulation Relapse Reporting Research Rewards Risk Risk-Taking Role Sampling Signal Transduction Substance abuse problem System Techniques Testing Time Undifferentiated Use of New Techniques Work addiction adverse outcome analog base control trial coping craving executive function expectation experience follow-up hemodynamics indexing male meetings neural circuit neuroimaging neuromechanism non-drug novel psychologic psychopathic personality relating to nervous system response social substance abuser tool treatment program

项目摘要

DESCRIPTION (provided by applicant): Real-world experience and clinical research converge in demonstrating that substance-abusers will continue to use drugs despite repeated adverse outcomes on physical and social well-being. This suggests that a characteristic of abuse may be a reduced ability to inhibit dysfunctional action patterns despite clear evidence of their maladaptivity (Paulus et al., 2002). Indeed, a growing body of behavioral, cognitive, electrophysiological and neuroimaging work suggests that cocaine abusers evidence core insensitivity to internally- and externally-generated signals of error. This insensitivity may reduce the ability to guide adaptive behavioral regulation, and may promote increased perseveration on dysfunctional action patterns, including repetitive drug-taking behavior and comorbid criminality. Despite this growing body of work, the nature of these error-monitoring deficits remains largely undifferentiated, however. Error-monitoring is composed of at least two potentially independent processes: an automatic error detection system that monitors for errors in goal-directed behavior and a less automatic system related to the conscious representation of that error. The majority of work evaluating error-monitoring in substance-dependent populations has focused on error-detection, and has reported consistent impairment. Little is currently understood regarding the state of subjective error-awareness in cocaine abusers, however, which precludes firm conclusions regarding the underlying nature of these error-monitoring deficits. Recent developments in electrophysiological and hemodynamic methods now afford the systematic isolation and evaluation of indices of automatic error-detection and conscious error-awareness, respectively. The present proposal seeks to build off these advances by collecting electrophysiological (EEG) and functional magnetic resonance imaging (fMRI) data within a sample of cocaine abusers (and matched controls), to characterize the integrity of neural circuits underlying their automatic and conscious components of error monitoring, respectively. The Mind Research Network has acquired a state-of-the-art mobile MRI scanner, deployed to various male and female correctional facilities, where epidimiological data indicates that over 65% of inmates suffer from serious substance abuse issues. The deployment of this mobile MRI system thus provides unprecedented access to a population of serious cocaine abusers with comorbid externalizing characteristics. With this access, we propose to collect multimodal (EEG/fMRI) data on 138 incarcerated participants, stratified into two groups: those who do (n = 69) and d not (n = 69) meet criteria for cocaine abuse. Participants will perform a time-estimation task that will afford a carefully controlled evaluation of the integrity of both automatic and concious components of error-monitoring within cocaine abusing individuals. In addition, we plan to follow-up our cocaine abusing participants at 1-year post-incarceration, to evaluate the extent to which error-monitoring integrity predicts future abstinence and relapse rates. The data obtained through this project will serve as the most comprehensive investigation of error monitoring abnormalities within a sample of serious cocaine abusers. The ultimate mission of The Mind Research Network is the development of novel treatment programs for serious psychological and mental disorders, and our group envisions the data collected fom this research as an important step towards future work focused on potential therepeutic and treatment applications.

描述（由申请人提供）：现实世界的经验和临床研究集中证明，尽管药物滥用者的身体和社会福祉一再出现不良后果，但药物滥用者仍将继续使用药物。这表明虐待的一个特征可能是抑制功能失调的行为模式的能力下降，尽管有明确的证据表明其适应不良（Paulus et al., 2002）。事实上，越来越多的行为、认知、电生理和神经影像学研究表明，可卡因滥用者对内部和外部产生的错误信号表现出核心不敏感。这种不敏感可能会降低指导适应性行为调节的能力，并可能促进对功能失调的行为模式的持续增加，包括重复吸毒行为和共病犯罪。然而，尽管工作量不断增加，这些错误监控缺陷的性质在很大程度上仍然没有区别。错误监控至少由两个潜在独立的过程组成：一个自动错误检测系统，用于监控目标导向行为中的错误；以及一个与该错误的有意识表示相关的不太自动化的系统。大多数评估物质依赖人群错误监测的工作都集中在错误检测上，并报告了一致的损害。然而，目前对可卡因滥用者的主观错误意识状态知之甚少，这排除了关于这些错误监控缺陷的根本性质的明确结论。电生理学和血液动力学方法的最新发展现在分别提供了自动错误检测和有意识错误意识指标的系统分离和评估。目前的提案旨在通过收集可卡因滥用者（和匹配对照）样本中的电生理学（EEG）和功能磁共振成像（fMRI）数据来建立这些进步，以分别表征其错误监控的自动和有意识成分背后的神经回路的完整性。 Mind Research Network 购买了一台最先进的移动 MRI 扫描仪，部署到各个男性和女性惩教设施中，流行病学数据表明，超过 65% 的囚犯患有严重的药物滥用问题。因此，这种移动 MRI 系统的部署为具有共病外化特征的严重可卡因滥用者提供了前所未有的机会。通过这种访问，我们建议收集 138 名被监禁参与者的多模态 (EEG/fMRI) 数据，并将其分为两组：符合可卡因滥用标准的人 (n = 69) 和不符合可卡因滥用标准的人 (n = 69)。参与者将执行一项时间估计任务，该任务将对可卡因滥用者中自动和有意识的错误监控部分的完整性进行仔细控制的评估。此外，我们计划在监禁后一年对可卡因滥用参与者进行随访，以评估错误监控完整性在多大程度上预测未来的戒断率和复发率。通过该项目获得的数据将作为对严重可卡因滥用者样本中错误监测异常情况的最全面调查。心灵研究网络的最终使命是为严重的心理和精神障碍开发新颖的治疗方案，我们的小组设想从这项研究中收集的数据是朝着未来专注于潜在的治疗和治疗应用的工作迈出的重要一步。