Differential contributions of frontal lobe areas to eye/hand coordination

额叶区域对眼/手协调的不同贡献

• 批准号: 8849986
• 负责人: Aaron Paul Batista
• 金额: $ 32.37万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8849986
• 关键词: Affect; American; Amyotrophic Lateral Sclerosis; Animals; Anterior; Area; Behavior; Behavioral; Brain; Brain Injuries; Cerebral cortex; Code; Data; Data Set; Dorsal; Environment; Eye; Eye Movements; Goals; Hand; Image; Individual; Learning; Life; Light; Longitudinal Studies; Macaca mulatta; Modality; Monkeys; Motor; Movement; Multiple Sclerosis; Muscle; Muscle Contraction; Nervous System Physiology; Neuraxis; Neuronal Plasticity; Neurons; Ocular Fixation; Pattern; Peripheral; Plastics; Positioning Attribute; Prevalence; Primates; Process; Property; Prosthesis Design; Research; Research Personnel; Retina; Rewards; Role; Saccades; Sensory; Shapes; Signal Transduction; Spinal cord injury; Staging; Technology; Testing; Training; Translations; Vision; Visual; Work; arm; arm movement; comparative; experience; eye hand coordination; flexibility; frontal lobe; gaze; grasp; innovation; interest; limb amputation; motivated behavior; motor control; motor disorder; multi-electrode arrays; neural prosthesis; novel; prevent; relating to nervous system; response; sample fixation; sensory mechanism; stroke recovery; visual motor

DESCRIPTION (provided by applicant): As we interact with our environment, we perform dextrous, coordinated movements of multiple effectors. I am particularly interested in eye/hand coordination - the processes by which we use vision to guide our arm and hand movements. We study the premotor cortex in Rhesus monkeys trained to perform visuomotor behaviors. Neurons in premotor cortex are active in relation to reaching, and some of them project polysynaptically to the eye muscles, which implicates them in eye/hand coordination. The two overarching goals of this research are complementary: First, we will study the conditions under which sensory-motor transformations can be modified. Our pilot data suggest that training experience and the immediate demands of behavior can shape neural response properties, causing premotor neurons to become more sensitive to the position of the eyes. Inducing a sensitivity to a new sensory modality is an extreme form of neural plasticity, of a type typically only seen after brain injury. The second goal of this research is to explore the role of the premotor cortex in behavior. Our pilot data indicate that premotor cortex may be even more versatile and flexible than is typically assumed. The chief significance of this research is that it will change our understanding of sensory-motor processing by showing it is more flexible and malleable than has been presumed. The chief innovation is in our use of multielectrode array recordings to perform longitudinal studies of learning in multiple brain areas simultaneously. Our main approach is to record high-volume neural data sets from multiple cortical areas while monkeys learn and perform motor behaviors. This will provide a rich and high-impact data set that will yield detailed comparative information about the premotor cortices.

描述(申请人提供)：当我们与我们的环境互动时，我们执行灵活、协调的多个效应器的运动。我特别感兴趣的是眼睛/手的协调--我们用视觉来指导手臂和手的运动的过程。我们研究了受过视觉运动训练的恒河猴的运动前皮质。运动前皮质中的神经元与伸展有关，其中一些神经元以多突触的方式投射到眼肌，这意味着它们参与了眼/手的协调。这项研究的两个主要目标是相辅相成的：首先，我们将研究感觉-运动转换可以修改的条件。我们的实验数据表明，训练经验和行为的直接需求可以塑造神经反应属性，导致运动前神经元对眼睛的位置变得更加敏感。诱导对新感觉模式的敏感性是神经可塑性的一种极端形式，这种类型通常只在脑损伤后才能看到。这项研究的第二个目标是探索运动前皮质在行为中的作用。我们的试验数据表明，运动前皮质可能比通常假设的更加多才多艺和灵活。这项研究的主要意义在于，它将改变我们对感觉-运动加工的理解，表明它比人们想象的更灵活、更具延展性。主要的创新是我们使用多电极阵列记录来同时对多个大脑区域的学习进行纵向研究。我们的主要方法是记录来自多个大脑皮层区域的大量神经数据集，同时猴子学习和执行运动行为。这将提供一个丰富和高影响的数据集，将产生关于运动前皮质的详细比较信息。

项目成果

Brain-computer interface control along instructed paths.

• DOI: 10.1088/1741-2560/12/1/016015
• 发表时间: 2015-02
• 期刊: Journal of neural engineering
• 影响因子: 4
• 作者: Sadtler PT;Ryu SI;Tyler-Kabara EC;Yu BM;Batista AP
• 通讯作者: Batista AP

Extracting Low-Dimensional Latent Structure from Time Series in the Presence of Delays.

在存在延迟的情况下从时间序列中提取低维潜在结构。

• DOI: 10.1162/neco_a_00759
• 发表时间: 2015-09
• 期刊: Neural computation
• 影响因子: 2.9
• 作者: Lakshmanan KC;Sadtler PT;Tyler-Kabara EC;Batista AP;Yu BM
• 通讯作者: Yu BM

Assessing vibrotactile feedback strategies by controlling a cursor with unstable dynamics.

通过控制动态不稳定的光标来评估振动触觉反馈策略。

• DOI: 10.1109/embc.2014.6944152
• 发表时间: 2014
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Quick,KristinM;Card,NicholasS;Whaite,StephenM;Mischel,Jessica;Loughlin,Patrick;Batista,AaronP
• 通讯作者: Batista,AaronP

Neural constraints on learning.

• DOI: 10.1038/nature13665
• 发表时间: 2014-08-28
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Sadtler, Patrick T.;Quick, Kristin M.;Golub, Matthew D.;Chase, Steven M.;Ryu, Stephen I.;Tyler-Kabara, Elizabeth C.;Yu, Byron M.;Batista, Aaron P.
• 通讯作者: Batista, Aaron P.

Brain-computer interfaces for dissecting cognitive processes underlying sensorimotor control.

• DOI: 10.1016/j.conb.2015.12.005
• 发表时间: 2016-04
• 期刊: Current opinion in neurobiology
• 影响因子: 5.7
• 作者: Golub MD;Chase SM;Batista AP;Yu BM
• 通讯作者: Yu BM