CRCNS Research Proposal: Collaborative Research: Neural Basis of Motor Expertise
CRCNS 研究提案:合作研究:运动专业知识的神经基础
基本信息
- 批准号:10623241
- 负责人:
- 金额:$ 39.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-15 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdoptedAnimalsAreaBackBehaviorBehavior ControlBehavioralBehavioral ParadigmBehavioral ResearchBrainCerebral cortexCharacteristicsClinicalCoffeeCollaborationsComplexDataDimensionsExhibitsExperimental DesignsFaceFeedbackGeneral PopulationGrainHandHealthHumanInstructionInvestmentsLaboratoriesLearningLifeMacaca mulattaManufactured basketballMathematicsModelingModernizationMonkeysMotorMotor SkillsMovementNational Institute of Neurological Disorders and StrokeNatureNervous System TraumaNeuronsNeurosciencesOral cavityPatientsPatternPopulation AnalysisPrimatesPrincipal InvestigatorRecoveryRehabilitation therapyResearchResearch ProposalsRouteShapesStrokeStructureTechniquesTestingWaterWorkbrain machine interfaceclinical applicationcomputational suitecomputerized toolscontrol theorydexterityexperienceexperimental studygrasphigh dimensionalityhuman subjectinsightinteractive toolmotor controlnervous system disorderneuralneural patterningneurological recoveryneuromuscular systemneurophysiologyneuroprosthesisnonhuman primatenoveloutreachparagonskillstoolvirtual environment
项目摘要
How can a basketball player reliably land his free throw in the basket, and yet still miss occasionally under
nominally identical circumstances? While such skills are a paragon of motor expertise, even seemingly
mundane actions also require surprising dexterity. When carrying a full cup of coffee, we exhibit motor
skill that is far beyond what is typically studied in the laboratory. Specifically, when interacting with objects
- the essence of any tool use -, successful actions require fine-grained control of interaction forces that
have been beyond the purview of neuroscience to date. The proposed research examines the neural
basis of motor expertise by bringing rich interactive tasks into the laboratory. The two PIs combine their
long-standing experience in computational motor control and neurophysiology to study novel behavioral
paradigms both in humans and non-human primates. Building on conceptual and computational overlap in
their respective research, where skill is associated with low-dimensional structure in high-dimensional
neural and behavioral redundant spaces, they will test the overall hypothesis that patterns of neural
activity exhibit many of the characteristics of the behavior. Two aims will study two examples of motor
skill: throwing an object and transporting an object with internal dynamics, both rendered in virtual
environments. Parallel experiments in humans and primates will generate rich behavioral data that will be
matched with intracortical recordings in the cerebral cortex of non-human primates. To date, non-human
primate studies have necessitated that animals perform near-identical repetitions of simple behaviors to
facilitate the analysis of neural activity. Now, modern multi-neuronal recording techniques make it possible
to embrace more sophisticated real-world behaviors and address core principles of movement discovered
in human motor control: high dimensionality, redundancy, and the ever-present variability. This research
will develop a suite of computational tools that afford the analysis of behavioral and neural data with
commensurate techniques and sophistication. This research will be transformative as it advances the
motor challenges examined and brings insights from intracortical neurophysiology closer to understanding
of human motor expertise. These scientific insights will channel into a large range of outreach activities to
achieve broader impacts for the general public.
RELEVANCE (See instructions):
Patients with neurological disorders such as stroke face challenges in their daily activities, grasping a cup
to bring to their mouths to drink; these actions are essentially interactive tool use. This research seeks
insights into neural activation during such skilled actions and interactions to get closer to understand
neural activity in tasks relevant in real life. Extending from PI Batista’s experience, neuroprosthetics and
brain-machine interfaces are direct clinical application that may benefit from our findings and recovery
一个篮球运动员怎么能可靠地把罚球投进篮筐,但偶尔仍投丢呢
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Novel Platform for Quantitative Assessment of Functional Object Interactions After Stroke.
- DOI:10.1109/tnsre.2022.3226067
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Preparing to move: Setting initial conditions to simplify interactions with complex objects.
- DOI:10.1371/journal.pcbi.1009597
- 发表时间:2021-12
- 期刊:
- 影响因子:4.3
- 作者:Nayeem R;Bazzi S;Sadeghi M;Hogan N;Sternad D
- 通讯作者:Sternad D
Neural Encoding and Representation of Time for Sensorimotor Control and Learning
- DOI:10.1523/jneurosci.1652-20.2020
- 发表时间:2021-02-03
- 期刊:
- 影响因子:5.3
- 作者:Balasubramaniam, Ramesh;Haegens, Saskia;Song, Joo-Hyun
- 通讯作者:Song, Joo-Hyun
Central nervous system physiology.
- DOI:10.1016/j.clinph.2021.09.013
- 发表时间:2021-12
- 期刊:
- 影响因子:0
- 作者:Rothwell J;Antal A;Burke D;Carlsen A;Georgiev D;Jahanshahi M;Sternad D;Valls-Solé J;Ziemann U
- 通讯作者:Ziemann U
Back to reality: differences in learning strategy in a simplified virtual and a real throwing task.
回到现实:简化的虚拟和真实投掷任务中学习策略的差异。
- DOI:10.1152/jn.00197.2020
- 发表时间:2021
- 期刊:
- 影响因子:2.5
- 作者:Zhang,Zhaoran;Sternad,Dagmar
- 通讯作者:Sternad,Dagmar
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Aaron Paul Batista其他文献
Aaron Paul Batista的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Aaron Paul Batista', 18)}}的其他基金
CRCNS Research Proposal: Collaborative Research: Neural Basis of Motor Expertise
CRCNS 研究提案:合作研究:运动专业知识的神经基础
- 批准号:
10405066 - 财政年份:2020
- 资助金额:
$ 39.1万 - 项目类别:
CRCNS: Dynamical Constraints on Neural Population Activity
CRCNS:神经群体活动的动态约束
- 批准号:
10268145 - 财政年份:2017
- 资助金额:
$ 39.1万 - 项目类别:
Multisensory Integration in Action: a Multineuronal and Feedback-Control Approach
行动中的多感觉整合:多神经元和反馈控制方法
- 批准号:
9219134 - 财政年份:2017
- 资助金额:
$ 39.1万 - 项目类别:
CRCNS: Dynamical Constraints on Neural Population Activity
CRCNS:神经群体活动的动态约束
- 批准号:
9472546 - 财政年份:2017
- 资助金额:
$ 39.1万 - 项目类别:
CRCNS: Dynamical Constraints on Neural Population Activity
CRCNS:神经群体活动的动态约束
- 批准号:
9906941 - 财政年份:2017
- 资助金额:
$ 39.1万 - 项目类别:
CRCNS:Dissecting brain-computer interfaces:a manifold & feedback-control approach
CRCNS:剖析脑机接口:流形
- 批准号:
8336883 - 财政年份:2011
- 资助金额:
$ 39.1万 - 项目类别:
Differential contributions of frontal lobe areas to eye/hand coordination
额叶区域对眼/手协调的不同贡献
- 批准号:
8685340 - 财政年份:2011
- 资助金额:
$ 39.1万 - 项目类别:
相似海外基金
How novices write code: discovering best practices and how they can be adopted
新手如何编写代码:发现最佳实践以及如何采用它们
- 批准号:
2315783 - 财政年份:2023
- 资助金额:
$ 39.1万 - 项目类别:
Standard Grant
One or Several Mothers: The Adopted Child as Critical and Clinical Subject
一位或多位母亲:收养的孩子作为关键和临床对象
- 批准号:
2719534 - 财政年份:2022
- 资助金额:
$ 39.1万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633211 - 财政年份:2020
- 资助金额:
$ 39.1万 - 项目类别:
Studentship
A material investigation of the ceramic shards excavated from the Omuro Ninsei kiln site: Production techniques adopted by Nonomura Ninsei.
对大室仁清窑遗址出土的陶瓷碎片进行材质调查:野野村仁清采用的生产技术。
- 批准号:
20K01113 - 财政年份:2020
- 资助金额:
$ 39.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2436895 - 财政年份:2020
- 资助金额:
$ 39.1万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633207 - 财政年份:2020
- 资助金额:
$ 39.1万 - 项目类别:
Studentship
The limits of development: State structural policy, comparing systems adopted in two European mountain regions (1945-1989)
发展的限制:国家结构政策,比较欧洲两个山区采用的制度(1945-1989)
- 批准号:
426559561 - 财政年份:2019
- 资助金额:
$ 39.1万 - 项目类别:
Research Grants
Securing a Sense of Safety for Adopted Children in Middle Childhood
确保被收养儿童的中期安全感
- 批准号:
2236701 - 财政年份:2019
- 资助金额:
$ 39.1万 - 项目类别:
Studentship
A Study on Mutual Funds Adopted for Individual Defined Contribution Pension Plans
个人设定缴存养老金计划采用共同基金的研究
- 批准号:
19K01745 - 财政年份:2019
- 资助金额:
$ 39.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Structural and functional analyses of a bacterial protein translocation domain that has adopted diverse pathogenic effector functions within host cells
对宿主细胞内采用多种致病效应功能的细菌蛋白易位结构域进行结构和功能分析
- 批准号:
415543446 - 财政年份:2019
- 资助金额:
$ 39.1万 - 项目类别:
Research Fellowships














{{item.name}}会员




