Memory Formation in Motor Cortex

运动皮层的记忆形成

基本信息

项目摘要

Project Summary: Memory Formation in Motor Cortex Memories both impart identity and provide competence in our daily activities. Our motor memories are crucial for interacting with the world around us: The loss of dexterity can be a particularly debilitating consequence of stroke. Despite their importance, we still know very little about how the brain forms and stores the memories of our motor abilities. This research project endeavors to understand the role of the primary motor cortex (M1) in the inception and retention of motor memories. Since it is the organized activity of populations of neurons that control our movements, we seek signatures of memories in how neural populations change their activity after a learning experience. We adopt a powerful tool for studying learning in the motor cortex – brain computer interfaces (BCIs). In a BCI, the user generates patterns of neural activity which drive the movement of an external device, such as a cursor on a computer screen. Decades of prior research have demonstrated the validity of BCIs as a tool to study learning in the motor system, and here we leverage that prior research to study motor memories. Our three Specific Aims address different aspects of motor memories: First, we examine the link between signatures of a memory in M1 population activity and improved behavioral performance following learning. Second, we examine how learning something new is influenced by the memory of a previous learning experience, and conversely, how new learning can impact the neural encoding of an existing motor memory. Third, we examine the consolidation of motor memories, to see what changes in the days after a learning experience. Our BCI paradigm offers powerful advantages for exploring these questions. This is because a BCI directly couples neural population activity to a behavior. This direct causal relationship makes it possible to see the appearance of a motor memory that is specific to and appropriate for the behavior that has been learned, and to track it over time. Also, because we use BCI systems in our basic-science studies, our findings have direct clinical relevance for the ongoing effort to improve BCIs so that they can restore dexterous and flexible motor control to individuals with paralysis.
项目总结:运动皮层的记忆形成

项目成果

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Aaron Paul Batista其他文献

Aaron Paul Batista的其他文献

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{{ truncateString('Aaron Paul Batista', 18)}}的其他基金

Neural Mechanisms of Motivated Movement
动机运动的神经机制
  • 批准号:
    10608228
  • 财政年份:
    2023
  • 资助金额:
    $ 57.35万
  • 项目类别:
Memory Formation in Motor Cortex
运动皮层的记忆形成
  • 批准号:
    10607176
  • 财政年份:
    2022
  • 资助金额:
    $ 57.35万
  • 项目类别:
CRCNS Research Proposal: Collaborative Research: Neural Basis of Motor Expertise
CRCNS 研究提案:合作研究:运动专业知识的神经基础
  • 批准号:
    10405066
  • 财政年份:
    2020
  • 资助金额:
    $ 57.35万
  • 项目类别:
CRCNS Research Proposal: Collaborative Research: Neural Basis of Motor Expertise
CRCNS 研究提案:合作研究:运动专业知识的神经基础
  • 批准号:
    10623241
  • 财政年份:
    2020
  • 资助金额:
    $ 57.35万
  • 项目类别:
CRCNS: Dynamical Constraints on Neural Population Activity
CRCNS:神经群体活动的动态约束
  • 批准号:
    10268145
  • 财政年份:
    2017
  • 资助金额:
    $ 57.35万
  • 项目类别:
Multisensory Integration in Action: a Multineuronal and Feedback-Control Approach
行动中的多感觉整合:多神经元和反馈控制方法
  • 批准号:
    9219134
  • 财政年份:
    2017
  • 资助金额:
    $ 57.35万
  • 项目类别:
CRCNS: Dynamical Constraints on Neural Population Activity
CRCNS:神经群体活动的动态约束
  • 批准号:
    9472546
  • 财政年份:
    2017
  • 资助金额:
    $ 57.35万
  • 项目类别:
CRCNS: Dynamical Constraints on Neural Population Activity
CRCNS:神经群体活动的动态约束
  • 批准号:
    9906941
  • 财政年份:
    2017
  • 资助金额:
    $ 57.35万
  • 项目类别:
CRCNS:Dissecting brain-computer interfaces:a manifold & feedback-control approach
CRCNS:剖析脑机接口:流形
  • 批准号:
    8336883
  • 财政年份:
    2011
  • 资助金额:
    $ 57.35万
  • 项目类别:
Differential contributions of frontal lobe areas to eye/hand coordination
额叶区域对眼/手协调的不同贡献
  • 批准号:
    8685340
  • 财政年份:
    2011
  • 资助金额:
    $ 57.35万
  • 项目类别:

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