T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer Research

T32：癌症研究纳米技术博士前和博士后培训项目

• 批准号: 9341081
• 负责人: Denis Wirtz
• 金额: $ 32.58万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9341081
• 关键词: Nanotechnology; Training Programs; anticancer research; post-doctoral training; pre-doctoral

 DESCRIPTION (provided by applicant): The interface between nanotechnology and medicine is a new frontier for scientific exploration and for the creation of new and improved diagnostic and therapeutic tools to detect, treat, cure, and prevent human diseases. We propose to create an integrated predoctoral and postdoctoral training program in nanotechnology for cancer research (NTCR) that is positioned at this interface. It is based on two parent R25 and T32 training grants in the same area. This program will establish a unique national resource with interdisciplinary and synergistic programs in fundamental research in cancer biology, industrial collaboration, and translational research in cancer medicine. This program fosters predoctoral and postdoctoral fellows who are trained across disciplines to lay foundations for technologies that enable an inside-view of cancer cell functions as opposed to the limited black-box input-output techniques currently used, introduce new modalities for molecular imaging, develop new high-throughput diagnostic tools, and engineer novel drug/antibody/siRNA viral and non-viral delivery systems to treat human cancers. NTCR fellows develop novel cancer diagnostics to evaluate each individual patient's prognosis and optimal treatment, based upon the patients' genetic and epigenetic markers and disease phenotype and therapeutics that are selected and optimized for each individual patient. NTCR trainees take one of two core courses depending on their background, as well as a lab course in cancer nanobiotechnology. They participate in a journal club and a dedicated annual symposium, as well as clinical conferences and tumor boards. The NTCR program will recruit outstanding trainees every year with MD and/or PhD degrees and diverse backgrounds in either biochemistry, physics, molecular/cellular/cancer biology, or an engineering/physics discipline for a steady state number of 2 postdoctoral and 6 predoctoral fellows. NTCR fellows take advantage of research and clinical resources at the NCI-designated Sidney Kimmel Comprehensive Cancer Center, the Ludwick Center for Cancer Genetics and Therapeutics, The Sol Goldman Pancreatic Cancer Center, and the In Vivo Cellular and Molecular Imaging Center, as well as the unique educational resources and experimental facilities of the recently established Johns Hopkins Institute for NanoBioTechnology (INBT), which houses the center for cancer nanotechnology excellence (CCNE) and the physical sciences-oncology center (PSOC). Relevance to Public Health. The proposed predoctoral and postdoctoral training program will train fellows at the interface between nanotechnology and cancer medicine to develop novel nanoscale therapeutic, prognostic, and diagnostic tools for the detection, diagnosis, treatment and cure of human cancer.

 描述（由申请人提供）：纳米技术和医学之间的结合是科学探索和创建新的和改进的诊断和治疗工具来检测、治疗、治愈和预防人类疾病的新领域。我们建议在这个界面上创建一个癌症研究纳米技术（NTCR）的综合博士前和博士后培训计划。它基于同一地区的两项家长 R25 和 T32 培训补助金。该项目将在癌症生物学基础研究、工业合作和癌症医学转化研究方面建立一个独特的国家资源，包括跨学科和协同项目。该项目培养经过跨学科培训的博士前和博士后研究员，为能够深入了解癌细胞功能的技术奠定基础，而不是目前使用的有限的黑盒输入输出技术，引入新的分子成像模式，开发新的高通量诊断工具，并设计新的药物/抗体/siRNA病毒和非病毒传递系统来治疗人类 癌症。 NTCR 研究员开发新型癌症诊断方法，根据患者的遗传和表观遗传标记以及为每位患者选择和优化的疾病表型和治疗方法，评估每位患者的预后和最佳治疗。 NTCR 学员根据其背景选修两门核心课程之一，以及癌症纳米生物技术实验课程。他们参加期刊俱乐部和专门的年度研讨会，以及临床会议和肿瘤委员会。 NTCR 项目每年都会招募具有医学博士和/或博士学位以及生物化学、物理学、分子/细胞/癌症生物学或工程/物理学科不同背景的优秀学员，稳定数量为 2 名博士后和 6 名博士前研究员。 NTCR 研究员利用 NCI 指定的 Sidney Kimmel 综合癌症中心、路德威克癌症遗传学和治疗中心、Sol Goldman 胰腺癌中心和体内细胞和分子成像中心的研究和临床资源，以及最近成立的约翰·霍普金斯纳米生物技术研究所 (INBT) 独特的教育资源和实验设施， 其中设有癌症纳米技术卓越中心 (CCNE) 和物理科学肿瘤学中心 (PSOC)。与公共卫生的相关性。拟议的博士前和博士后培训计划将培训纳米技术和癌症医学交叉领域的研究员，开发新型纳米级治疗、预后和诊断工具，用于人类癌症的检测、诊断、治疗和治愈。