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Conduct of studies to evaluate the toxic potential of C9-alkylbenzenes in laboratory animals for the National Toxicology Program (NTP)

Conduct of studies to evaluate the toxic potential of C9-alkylbenzenes in laboratory animals for the National Toxicology Program (NTP)
为国家毒理学计划 (NTP) 开展研究，评估 C9-烷基苯对实验动物的潜在毒性
批准号：
9471293
负责人：
BARNEY SPARROW
金额：
$167.03万
依托单位：
BATTELLE MEMORIAL INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-04-15 至 2018-04-14
来源：
https://reporter.nih.gov/project-details/9471293
关键词：
AnimalsBreathingChemicalsChronicDataGoalsHumanLaboratory AnimalsNational Toxicology ProgramPathology ReportPhaseRiskToxic effectToxicity TestsVanadiumcarcinogenicitydesignhazardneurotoxicityreproductive

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中文摘要
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英文摘要
The goal of this project is to evaluate the toxicity C9-alkylbenzenes, including 1,2,4-trimethylbenzene and a 2-ethyltoluene, following exposure via inhalation. Three-month studies of 1,2,4-trimethylbenzene are in the pathology/reporting phase. 2-week studies of 2-ethyltoluene are approved and will be used to design 3-month studies. Humans are likely to be similarly exposed to these compounds via inhalation. These subchronic studies will provide valuable data on general toxicity as well as reproductive and neurotoxicity and will aid in the design of chronic toxicity/carcinogenicity studies. Keywords: toxicity, inhalation, vanadium, trimethylbenzene, ethyltoluene.
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