Conduct of studies to evaluate the toxic potential of C9-alkylbenzenes in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估 C9-烷基苯对实验动物的潜在毒性

• 批准号: 9471293
• 负责人: BARNEY SPARROW
• 金额: $ 167.03万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2018-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9471293
• 关键词: Animals; Breathing; Chemicals; Chronic; Data; Goals; Human; Laboratory Animals; National Toxicology Program; Pathology Report; Phase; Risk; Toxic effect; Toxicity Tests; Vanadium; carcinogenicity; design; hazard; neurotoxicity; reproductive

The goal of this project is to evaluate the toxicity C9-alkylbenzenes, including 1,2,4-trimethylbenzene and a 2-ethyltoluene, following exposure via inhalation. Three-month studies of 1,2,4-trimethylbenzene are in the pathology/reporting phase. 2-week studies of 2-ethyltoluene are approved and will be used to design 3-month studies. Humans are likely to be similarly exposed to these compounds via inhalation. These subchronic studies will provide valuable data on general toxicity as well as reproductive and neurotoxicity and will aid in the design of chronic toxicity/carcinogenicity studies. Keywords: toxicity, inhalation, vanadium, trimethylbenzene, ethyltoluene.

本项目的目标是评估吸入接触C9-烷基苯（包括1，2，4-三甲基苯和2-乙基甲苯）后的毒性。对1，2，4-三甲基苯进行的为期三个月的研究正处于病理学/报告阶段。2-2-乙基甲苯的为期一周的研究已获批准，并将用于设计为期3个月的研究。人类可能通过吸入类似地暴露于这些化合物。这些亚慢性研究将提供关于一般毒性以及生殖和神经毒性的宝贵数据，并将有助于慢性毒性/致癌性研究的设计。 关键词：毒性，吸入，钒，三甲苯，乙基甲苯。