Institutional Center Cores for Advanced Neuroimaging

这项建议的总体目标是继续成功的NINDS机构中心核心(第30页 NS076408)，明尼苏达大学磁共振研究中心(CMRR) (UMN)。这些核心提供最先进的仪器、先进的技术和独特的 在CMRR生物医学成像方面的专业知识，以提供尖端资源和设施 现有NINDS资助的研究项目通过以下途径服务于NINDS任务的调查人员 对正常和疾病神经系统的基础研究、翻译研究和临床研究在最后一次 25年来，磁共振(MR)技术已经发展成为 在健康和疾病的大脑研究中不可或缺的，通过提供其他方面不可用的 在人类和动物模型中的测量能力。这些技术的最佳使用 需要先进的工具、独特的专业知识和复杂的辅助功能，例如 动物外科、大规模数据和图像处理以及补充测量 使用经典技术(例如，电生理学和组织学)。使用这些设施和 方法论，尤其是前沿的方法论，在单独的实验室里几乎是不可能的。建议数 NINDS Center核心将提供并鼓励使用这些先进技术和 相关的独特专业知识，以扩大NINDS资助的神经科学研究。这些目标将是 通过三个科学核心完成： 1.MR图像采集和工程核心(为了提供特定于应用的脉冲序列， 和硬件，如射频线圈)(PI：Pierre-Francois van de Moortele；co-Pi Gulin Oz) 2.MR数据分析和可视化核心(提供特定于应用的图像和 光谱分析工具和支持)(PI：Christophe Lenglet；共同PI Noam Harel) 3.多模核心(支持互补的非成像测量能力)(PI： Geoff Ghose) 这笔赠款的总体目标是在多学科的、互动的 研究环境，以丰富和促进新的研究成果 为大量正在进行的NINDS资助的研究项目指明方向。

The general aim of this proposal is to continue the successful NINDS Institutional Center Cores (P30 NS076408) at the Center for Magnetic Resonance Research (CMRR), University of Minnesota (UMN). These Cores offer state-of-the-art instrumentation, advanced technology, and unique expertise for biomedical imaging in CMRR so as to provide cutting edge resources and facilities to investigators who have existing NINDS-funded research projects serving the NINDS mission through “basic, translational, and clinical research on the normal and diseased nervous system”. In the last two and a half decades, magnetic resonance (MR) techniques have evolved to become indispensable in studies of the brain in health and disease by providing otherwise unavailable measurement capabilities in humans and animal models. The optimal use of these techniques requires advanced instrumentation, unique expertise, and complex auxiliary capabilities such as animal surgery, large-scale data and image processing, and complementary measurements employing classical techniques (e.g., electrophysiology and histology). Access to these facilities and methodologies, especially at the cutting-edge, is virtually impossible in individual labs. The proposed NINDS Center Cores will provide and encourage access to these advanced technologies and associated unique expertise to amplify NINDS funded neuroscience research. These aims will be accomplished through three scientific Cores: 1. MR Image Acquisition and Engineering Core (to provide application specific pulse sequences, and hardware, such as RF coils) (PI: Pierre-Francois van de Moortele; co-PI Gulin Oz) 2. MR Data Analysis and Visualization Core (to provide applications specific image and spectroscopic analysis tools and support) (PI: Christophe Lenglet; co-PI Noam Harel) 3. Multimodality Core (to support complementary non-imaging measurement capabilities) (PI: Geoff Ghose) The overall aim of this grant is to provide this access within the multidisciplinary, and interactive research environment of CMRR, so as to enrich the effectiveness of and promote new research directions in a large number of ongoing NINDS funded research projects.