Institutional Center Cores for Advanced Neuroimaging

高级神经影像机构中心核心

• 批准号: 9432736
• 负责人: KAMIL UGURBIL
• 金额: $ 44.78万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9432736
• 关键词: Animal Model; Animals; Basic Science; Brain; Clinical Research; Complex; Computers and Advanced Instrumentation; Core Facility; Data Analyses; Disease; Effectiveness; Electrophysiology (science); Engineering; Environment; Functional Magnetic Resonance Imaging; Funding; Grant; Health; Histology; Human; Image; Imagery; Individual; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Methodology; Minnesota; Mission; National Institute of Neurological Disorders and Stroke; Neurosciences; Neurosciences Research; Operative Surgical Procedures; Physiologic pulse; RF coil; Research; Research Personnel; Research Project Grants; Research Support; Resources; Science; Spectrum Analysis; Techniques; Technology; Translational Research; Universities; bioimaging; computerized data processing; data visualization; image processing; instrumentation; magnetic field; multidisciplinary; multimodality; nervous system disorder; neuroimaging; new technology; ranpirnase; spectroscopic imaging; tool; virtual

The general aim of this proposal is to continue the successful NINDS Institutional Center Cores (P30 NS076408) at the Center for Magnetic Resonance Research (CMRR), University of Minnesota (UMN). These Cores offer state-of-the-art instrumentation, advanced technology, and unique expertise for biomedical imaging in CMRR so as to provide cutting edge resources and facilities to investigators who have existing NINDS-funded research projects serving the NINDS mission through “basic, translational, and clinical research on the normal and diseased nervous system”. In the last two and a half decades, magnetic resonance (MR) techniques have evolved to become indispensable in studies of the brain in health and disease by providing otherwise unavailable measurement capabilities in humans and animal models. The optimal use of these techniques requires advanced instrumentation, unique expertise, and complex auxiliary capabilities such as animal surgery, large-scale data and image processing, and complementary measurements employing classical techniques (e.g., electrophysiology and histology). Access to these facilities and methodologies, especially at the cutting-edge, is virtually impossible in individual labs. The proposed NINDS Center Cores will provide and encourage access to these advanced technologies and associated unique expertise to amplify NINDS funded neuroscience research. These aims will be accomplished through three scientific Cores: 1. MR Image Acquisition and Engineering Core (to provide application specific pulse sequences, and hardware, such as RF coils) (PI: Pierre-Francois van de Moortele; co-PI Gulin Oz) 2. MR Data Analysis and Visualization Core (to provide applications specific image and spectroscopic analysis tools and support) (PI: Christophe Lenglet; co-PI Noam Harel) 3. Multimodality Core (to support complementary non-imaging measurement capabilities) (PI: Geoff Ghose) The overall aim of this grant is to provide this access within the multidisciplinary, and interactive research environment of CMRR, so as to enrich the effectiveness of and promote new research directions in a large number of ongoing NINDS funded research projects.

该提案的总体目标是继续成功的 NINDS 机构中心核心 (P30 NS076408），明尼苏达大学磁共振研究中心（CMRR） （UMN）。这些核心提供最先进的仪器、先进的技术和独特的 CMRR 生物医学成像专业知识，以便提供尖端资源和设施 现有 NINDS 资助的研究项目的研究人员通过以下方式服务于 NINDS 任务： “对正常和患病神经系统的基础、转化和临床研究”。在最后 二十五年来，磁共振 (MR) 技术已经发展成为 通过提供其他方式无法获得的信息，在健康和疾病中的大脑研究中不可或缺 人类和动物模型的测量能力。这些技术的最佳使用 需要先进的仪器、独特的专业知识和复杂的辅助功能，例如 动物手术、大规模数据和图像处理以及补充测量 采用经典技术（例如电生理学和组织学）。使用这些设施和 方法论，尤其是前沿方法论，在单个实验室中几乎是不可能的。拟议的 NINDS 中心核心将提供并鼓励获得这些先进技术和 相关独特的专业知识，以扩大 NINDS 资助的神经科学研究。这些目标将是 通过三个科学核心完成： 1. MR 图像采集和工程核心（提供特定于应用的脉冲序列， 和硬件，如射频线圈）（PI：Pierre-Francois van de Moortele；联合 PI Gulin Oz） 2. MR数据分析和可视化核心（提供应用程序特定的图像和 光谱分析工具和支持）（PI：Christophe Lenglet；联合 PI Noam Harel） 3. 多模态核心（支持互补的非成像测量功能）（PI： 杰夫·高斯） 这笔赠款的总体目标是在多学科、互动的范围内提供这种机会 CMRR的研究环境，以丰富新研究的有效性并促进新研究 为大量正在进行的 NINDS 资助的研究项目提供指导。