Graduate Training in Integrative Physiology

项目摘要 这是T32申请的重新提交，要求为新的研究生综合培训提供资金 4名博士前研究员/年的生理学培训计划。将对博士前研究员进行培训 通过参与教师的跨学科研究的各种健康证明记录 问题.该计划的总体目标是提供现代研究方面的广泛培训 定量研究健康和疾病中生理过程的本质所需的概念 国家，这是必要的，以推动发现新的治疗策略，治疗的根本原因， 影响多个器官和系统的疾病。主要目标是：1）提供一个全面的， 为生理学早期学员提供定量培训计划，特别强调 心血管、衰老、神经生理学和肌肉生物学研究; 2）促进跨学科学习 由基础科学家、临床医生和受训人员组成的团队，以促进严格的创新转化科学。 博士前研究员将接受培训，在设计和进行基本的， 转化研究，以提高他们未来的能力，使广泛的疾病的治疗发现 作为独立的研究者。为了实现这一目标，博士前研究员将从事尖端， 定量的生理学研究。除了专门的教学课程，他们将参加 在一个全面的实验设计工作坊，并参加每周研讨会和盛大的回合 报告侧重于心血管、衰老相关、神经系统或肌肉骨骼疾病。虽然 预计大多数受训人员将从事以实验室为基础的发现研究，他们还将 接受培训，通过撰写赠款和沟通技巧向其他科学家传授知识 工作坊.这些培训途径的结合将提供传播知识的技能， 让他们了解如何设计和进行研究的方式，使他们能够 将有前景的疗法转化为临床。

Project Summary This is a resubmission of a T32 application requesting funding for a new Graduate Training in Integrative Physiology training program for 4 predoctoral fellows/year. Training of the predoctoral fellows will be carried out by participating faculty with proven track records of cross-disciplinary research on a variety of health issues. The overall goal of the proposed program is to provide broad-based training in modern research concepts required to study quantitatively the nature of physiological processes in both healthy and disease states, which is necessary to drive discovery of new therapeutic strategies for treating the underlying causes of diseases affecting multiple organs and systems. The primary objectives are to: 1) provide a comprehensive, quantitative training program for early stage trainees in physiology with a particular emphasis on cardiovascular, aging, neurophysiology, and muscle biology research; and 2) promote interdisciplinary learning teams involving basic scientists, clinicians and trainees to foster rigorous innovative translational science. Predoctoral fellows will be trained in the practical issues involved in the design and conduct of basic and translational research to enhance their future ability to make therapeutic discoveries for diseases of broad etiology as independent investigators. To accomplish this, the predoctoral fellows will engage in cutting-edge, quantitative, physiologically-based research. In addition to specialized didactic coursework, they will participate in a comprehensive Experimental Design Workshop and attend weekly seminars and grand rounds presentations focused on cardiovascular, aging-related, neurological, or musculoskeletal diseases. Although most of the trainees are anticipated to pursue careers in laboratory-based discovery research, they will also receive training in conveying knowledge to other scientists through grant-writing and communications skills workshops. The combination of these training avenues will provide skills to disseminate their knowledge and provide them with an understanding of how to design and conduct research in a manner that will enable the translation of promising therapies into the clinic.