Graduate Training in Integrative Physiology

项目摘要 这是一份重新提交的T32申请，要求为新的综合性大学毕业生培训提供资金 每年4名博士前研究员的生理学培训计划。将对博士后研究员进行培训 由参与的教员在各种健康的跨学科研究方面有良好的记录 问题。拟议方案的总体目标是提供现代研究方面的广泛培训 定量研究健康和疾病生理过程的本质所需的概念 国家，这是必要的，以推动发现新的治疗战略，以治疗的根本原因 影响多个器官和系统的疾病。主要目标是：1)提供全面、 生理学早期学员的量化培训计划，特别强调 心血管、衰老、神经生理学和肌肉生物学研究；以及2)促进跨学科学习 由基础科学家、临床医生和受训人员组成的团队，以培养严谨的创新翻译科学。 博士前研究员将接受有关设计和实施基础和 翻译研究，以提高他们未来对广泛疾病的治疗发现的能力 病因学作为独立的调查人员。为了做到这一点，博士后研究员将从事尖端技术， 基于生理学的定量研究。除了专业的教学课程外，他们还将参与 参加综合实验设计研讨会，并参加每周研讨会和大型研讨会 演讲的重点是心血管疾病、衰老相关疾病、神经疾病或肌肉骨骼疾病。虽然 大多数学员预计将从事以实验室为基础的发现研究，他们还将 接受通过撰写拨款和沟通技巧向其他科学家传授知识的培训 研讨会。这些培训途径的结合将提供传播其知识和 让他们了解如何设计和进行研究，使他们能够 将前景看好的疗法转化为临床。

Project Summary This is a resubmission of a T32 application requesting funding for a new Graduate Training in Integrative Physiology training program for 4 predoctoral fellows/year. Training of the predoctoral fellows will be carried out by participating faculty with proven track records of cross-disciplinary research on a variety of health issues. The overall goal of the proposed program is to provide broad-based training in modern research concepts required to study quantitatively the nature of physiological processes in both healthy and disease states, which is necessary to drive discovery of new therapeutic strategies for treating the underlying causes of diseases affecting multiple organs and systems. The primary objectives are to: 1) provide a comprehensive, quantitative training program for early stage trainees in physiology with a particular emphasis on cardiovascular, aging, neurophysiology, and muscle biology research; and 2) promote interdisciplinary learning teams involving basic scientists, clinicians and trainees to foster rigorous innovative translational science. Predoctoral fellows will be trained in the practical issues involved in the design and conduct of basic and translational research to enhance their future ability to make therapeutic discoveries for diseases of broad etiology as independent investigators. To accomplish this, the predoctoral fellows will engage in cutting-edge, quantitative, physiologically-based research. In addition to specialized didactic coursework, they will participate in a comprehensive Experimental Design Workshop and attend weekly seminars and grand rounds presentations focused on cardiovascular, aging-related, neurological, or musculoskeletal diseases. Although most of the trainees are anticipated to pursue careers in laboratory-based discovery research, they will also receive training in conveying knowledge to other scientists through grant-writing and communications skills workshops. The combination of these training avenues will provide skills to disseminate their knowledge and provide them with an understanding of how to design and conduct research in a manner that will enable the translation of promising therapies into the clinic.