Neural and behavioral correlates of deliberate emotion regulation in early childhood: testing unique links to emerging irritability.

幼儿期刻意情绪调节的神经和行为相关性：测试与新出现的烦躁的独特联系。

• 批准号: 9381118
• 负责人: Adam Grabell
• 金额: $ 17.37万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9381118
• 关键词: Age; Anger; Behavior; Behavioral; Child; Clinical; Data; Development; Diagnostic; Dimensions; Early Intervention; Electroencephalography; Emotional; Etiology; Facial Expression; Foxes; Frequencies; Frustration; Future; Growth; Heterogeneity; Individual Differences; Intervention; Link; Literature; Major Mental Illness; Measures; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Mission; Near-Infrared Spectroscopy; Nursery Schools; Parents; Population; Predisposition; Prefrontal Cortex; Property; Psychopathology; Recruitment Activity; Regulation; Research; Research Design; Sampling; Severities; Signal Transduction; Specificity; Stimulus; Symptoms; Testing; Training; Translating; Treatment Efficacy; Visit; Work; associated symptom; design; early childhood; effective therapy; emotion regulation; executive function; follow-up; innovation; interest; longitudinal design; member; neuroimaging; neuroregulation; novel; novel strategies; peer; programs; relating to nervous system; response; skills; statistics; translational research program

7. Project Summary. Irritability is a relative predisposition for angry responses to frustration that exists, at some level, in every member of the population, but at the severe end is a symptom transversing the internalizing and externalizing spectra and forecasting future mental illness. There has been increased interest in elucidating the specific deficits that 1) discriminate early irritability that is and is not prodromal to mental illness, and 2) could be reduced through novel intervention. Irritability is modulated by emotion regulation, which can be parsed into non-mutually exclusive automatic (immediate, reactive) and deliberate (longer-unfolding, effortful) response types. Deliberate emotion regulation, more so than automatic, requires greater prefrontal cortex activation and engagement of executive function for successful implementation, and thus may be a better auger of irritability severity and course and a more viable clinical target. However, deliberate emotion regulation is difficult to measure in early childhood and has been under-researched. The proposed Mentored Patient-Oriented Research Career Development Award will train the candidate to probe deliberate regulation in preschoolers ranging from low to severe irritability, over a period of rapid development, and connect findings to translational implications. The candidate's current expertise includes differentiating the normal:abnormal spectrum of emergent psychopathology, with a focus on early disruptive behavior, multivariate statistics, and some basic skills in acquiring and analyzing EEG and functional Near Infrared Spectroscopy (fNIRS) data. To launch a translational program of research that connects a detailed understanding of emotion regulation to emerging psychopathology and more effective treatments, the candidate seeks advanced training in 1) a multi-level approach linking emerging emotion regulation with irritability, 2) developing more refined treatment implications, and 3) longitudinal research. The candidate's mentorship team, Drs. Perlman, Wakschlag, Huppert, Kolko, Molina, and Fox, provide expertise in child neuroimaging, emotion regulation, and irritability, longitudinal design, and child treatment efficacy. The proposed study will examine early deliberate emotion regulation, its association with level of concurrent irritability, and changes in irritability, internalizing, and externalizing symptoms one year later. Children ages 3 and 5 years (n = 50) ranging from low to severe irritability will complete a validated automatic emotion regulation task followed by a novel deliberate emotion regulation task. An innovative multi-level approach will be used to isolate deliberate from automatic emotion regulation by simultaneously recording dorsolateral prefrontal cortex activation via fNIRS and facial expression via video. Children will complete the paradigm again one year later and parents will rate their child's irritability, internalizing, and externalizing symptoms at baseline and follow-up. The proposed study is designed to shift the field to focusing on deliberate emotion regulation, inform future longitudinal work, and spur novel interventions for early irritability. !

7。项目摘要。 易怒是对愤怒反应对挫败感的相对倾向，在某种程度上，每个级别都存在 人口的成员，但严重的末端是一种症状，横向内在化和外部化 光谱和预测未来的精神疾病。阐明特定的兴趣增加了 赤字是1）区分和不是精神疾病的原始人，而2）可能是 通过新颖的干预减少。烦恼是由情绪调节调节的，可以解释为 非少量排斥的自动（直接，反应性）和故意（较长，努力）的响应 类型。故意的情绪调节，而不是自动，需要更大的前额叶皮层激活和 执行功能成功实施，因此可能是更好的烦躁不安的螺旋杆 严重性和过程以及更可行的临床目标。但是，故意的情绪调节很难 在幼儿时期的措施，并被研究不足。 拟议的指导的以患者为导向的研究职业发展奖将培训候选人 在一段时间的快速期间 开发，并将发现与翻译含义联系起来。候选人当前的专业知识包括 区分正常：新兴心理病理学的异常谱，重点是早期破坏性 行为，多元统计以及一些基本技能，以获取和分析脑电图和功能 红外光谱（FNIRS）数据。启动一项连接详细的研究的翻译计划 了解情绪调节对新兴的心理病理学和更有效的治疗， 候选人寻求高级培训1）将新兴情绪调节与 烦躁，2）发展更精致的治疗含义，以及3）纵向研究。候选人的 指导团队，博士。 Perlman，Wakschlag，Huppert，Kolko，Molina和Fox为孩子提供专业知识 神经影像学，情绪调节和易怒，纵向设计和儿童治疗功效。 拟议的研究将检查早期故意的情绪调节，其与水平的关联 一年后，同时烦躁，易怒，内在化和外在症状的变化。 3岁和5岁的儿童（n = 50）范围从低到严重的烦躁不良，将完成经过验证的自动 情绪调节任务遵循新颖的故意情绪调节任务。创新的多层次 通过同时记录，方法将用于隔离自动情绪调节的故意。 通过FNIRS激活背外侧前额叶皮层，并通过视频表达面部表达。孩子们将完成 一年后再次范式，父母将对孩子的烦恼，内在化和外在化评分 基线和随访时的症状。拟议的研究旨在将领域转移到故意的重点 情绪调节，为未来的纵向工作提供信息，并刺激新的干预措施，以使早期的易怒。 呢