Virtual Brain Electrode (VIBE) for Imaging Neuronal Activity

用于神经元活动成像的虚拟脑电极 (VIBE)

• 批准号: 9302530
• 负责人: Jeff W. Bulte
• 金额: $ 38.56万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-24 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9302530
• 关键词: Action Potentials; Affect; Anxiety; Area; Auditory; Blood; Blood flow; Brain; Brain Diseases; Cell surface; Conscious; Dementia; Dependence; Development Plans; Devices; Diagnosis; Electrodes; Electroencephalogram; Encephalopathies; Epilepsy; Erythrocytes; Event-Related Potentials; Evoked Potentials; Functional Magnetic Resonance Imaging; Grant; Human; Image; Imaging Techniques; Implanted Electrodes; Label; Magnetic nanoparticles; Magnetism; Magnetoencephalography; Maps; Measurement; Measures; Membrane Potentials; Mental Depression; Methodology; Methods; Monoclonal Antibody R24; Neurons; Neurosciences; Phase; Process; Rattus; Research; Sensory; Shapes; Signal Transduction; Sleep Disorders; Techniques; Testing; Three-Dimensional Image; Time; Tissues; Translating; autism spectrum disorder; base; blood oxygen level dependent; brain tissue; design and construction; experimental study; human subject; in vivo; iron oxide; magnetic field; millisecond; nanoparticle; novel strategies; particle; public health relevance; response; source localization; spectroscopic imaging; temporal measurement; virtual

 DESCRIPTION (provided by applicant): A technique will be developed to determine where in the brain the signal in an electroencephalogram (EEG) is originating from in order to generate a "voxel-specific EEG", much like the signal coming from an implanted electrode. We propose to call this VIrtual Brain Electrode (VIBE) imaging. The method is based on the principle that red blood cells (RBCs), due to their specific shape and their insulating cell surface, affect the conductivity of the surrounding volume in dependence of their orientation. We propose to influence the orientation of the RBCs by loading them with magnetic nanoparticles and subjecting them to oscillating magnetic fields in a small volume around a field-free point (FFP), as known from Magnetic Particle Imaging (MPI). If, at the same time, we record an EEG, we expect a small modulation to be visible in the recorded signal originating from this volume. We are then able to determine the spatial origin of the EEG signal with high precision and, using methods similar to those used as in MR spectroscopic imaging, we will be able to create a specific 3D map for the origin of the EEG signal. This new methodology would contribute significantly to a better understanding of the normal functioning of the brain, applicable in healthy human subjects. In comparison to fMRI, our method would provide a higher temporal resolution of neuronal activation (equivalent to EEG) and reflect direct electric activation, as opposed to the indirect blood oxygenation-level dependent (BOLD) effect.



项目成果

Magnetic Manipulation of Blood Conductivity with Superparamagnetic Iron Oxide-Loaded Erythrocytes.

• DOI: 10.1021/acsami.9b00394
• 发表时间: 2019-03
• 期刊: ACS applied materials & interfaces
• 影响因子: 9.5
• 作者: Gavin R. Philips;B. Gleich;Genaro A. Paredes-Juarez;A. Antonelli;M. Magnani;J. Bulte