Integrative Analysis of Longitudinal Studies of Aging

老龄化纵向研究的综合分析

• 批准号: 9242533
• 负责人: SCOTT M. HOFER
• 金额: $ 157.48万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2020-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9242533
• 关键词: Affect; Age; Aging; Biological Markers; Birth; Cardiac; Characteristics; Chronic; Cognition; Cognitive; Collaborations; Computer software; Country; Coupled; Databases; Dementia; Developmental Course; Dimensions; Disease; Education; Elderly; Event; Future; Geography; Health; Healthcare; Individual; Individual Differences; Intercept; International; Ions; Knowledge; Life; Life Cycle Stages; Longitudinal Studies; Measurement; Measures; Meta-Analysis; Metadata; Methodology; Methods; Outcome; Pathologic; Pattern; Personality; Persons; Physical Function; Population; Process; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Priority; Resources; Risk; Risk Factors; Role; Sampling; Statistical Data Interpretation; Variant; Work; base; caregiving; cognitive change; cognitive function; cognitive performance; cohort; comparative; design; disease heterogeneity; health difference; interdisciplinary collaboration; longitudinal analysis; mortality; programs; public health relevance; response; social

DESCRIPTION (provided by applicant): The scientific discovery of life course determinants and understanding of within-person processes leading to health-related changes and accelerated aging is a major research priority internationally. The study of aging demands an integrative life course developmental framework, involving interdisciplinary collaborations and advanced methodological approaches for understanding how and why individuals change with age, in both normative and idiosyncratic ways. However, longitudinal research can present remarkable challenges. Replication and comparison of results must include consideration of the age range, birth cohort, culture, health and education of individuals in the sample, differences in measurements, design and statistical analysis, and issues such as rates of response, attrition, and mortality selection. In addition, an understanding of life course processes is embedded within an international and historical context, with consideration of country, culture, and historical differences necessary for evaluating reproducibility and generalizability of particular study findings. A vital function of this application is to further develop, maintain, and make use f an infrastructure for coordinated analysis of international longitudinal studies for advancing knowledge about aging-related change and life course determinants of such changes. The aims of the overall program project are: 1) To facilitate collaborative, coordinated, and pooled-data analysis of longitudinal studies of aging through the creation of a purpose-built research platform for aggregating and organizing metadata related to study and measurements; 2) To evaluate the impact of chronic health conditions and health-related biomarkers on aging-related change in cognitive and physical functioning; 3) To evaluate general patterns of population average and individual variation in aging, health, and mortality related change across distinct personality and well-being constructs in major longitudinal studies on aging; and 4) To evaluate the role of early life characteristics and social determinants ion aging-related change in cognition and health, with emphasis on differential risk and exposure processes.

描述（由申请人提供）：生命历程决定因素的科学发现和对导致健康相关变化和加速衰老的人内过程的理解是国际上的一个主要研究重点。老龄化的研究需要一个综合的生命历程发展框架，涉及跨学科的合作和先进的方法论方法，以了解个人如何以及为什么随着年龄的变化，在规范和特质的方式。然而，纵向研究可能会带来显著的挑战。结果的复制和比较必须包括考虑样本中个人的年龄范围、出生队列、文化、健康和教育、测量、设计和统计分析的差异以及应答率、自然减员和死亡率选择等问题。此外，生命过程的理解是嵌入在国际和历史背景下，考虑国家，文化和历史的差异，评估特定研究结果的再现性和普遍性。该应用程序的一个重要功能是进一步开发、维护和利用一个基础设施，对国际纵向研究进行协调分析，以增进对与衰老有关的变化和这种变化的生命过程决定因素的了解。整个计划项目的目标是：1）通过创建一个专门构建的研究平台，用于聚合和组织与研究和测量相关的元数据，促进老龄化纵向研究的协作，协调和汇总数据分析; 2）评估慢性健康状况和健康相关生物标志物对认知和身体功能老化相关变化的影响; 3）在主要的老龄化纵向研究中，评估人口平均和个体差异在老龄化、健康和死亡率相关变化中的一般模式;以及4）评估早期生命特征和社会决定因素在认知和健康方面与老龄化相关的变化中的作用，重点是不同的风险和暴露过程。

项目成果

The identification of regions of significance in the effect of multimorbidity on depressive symptoms using longitudinal data: an application of the Johnson-Neyman technique.

• DOI: 10.1159/000358757
• 发表时间: 2014
• 期刊: Gerontology
• 影响因子: 3.5
• 作者: Rast P;Rush J;Piccinin A;Hofer SM
• 通讯作者: Hofer SM

Trajectories of Personality Traits Preceding Dementia Diagnosis.

痴呆症诊断前的人格特征轨迹。

• DOI: 10.1093/geronb/gbw006
• 发表时间: 2017
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Yoneda,Tomiko;Rush,Jonathan;Berg,AnneIngeborg;Johansson,Boo;Piccinin,AndreaM
• 通讯作者: Piccinin,AndreaM

IQ as moderator of terminal decline in perceptual and motor speed, spatial, and verbal ability: Testing the cognitive reserve hypothesis in a population-based sample followed from age 70 until death.

智商作为知觉和运动速度、空间和语言能力最终下降的调节因素：在从 70 岁到死亡的人群样本中检验认知储备假设。

• DOI: 10.1037/pag0000150
• 发表时间: 2017
• 期刊: Psychology and aging
• 影响因子: 3.7
• 作者: Thorvaldsson,Valgeir;Skoog,Ingmar;Johansson,Boo
• 通讯作者: Johansson,Boo

Apolipoprotein-E (Apoe) ε4 and cognitive decline over the adult life course.

• DOI: 10.1038/s41398-017-0064-8
• 发表时间: 2018-01-10
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Rawle MJ;Davis D;Bendayan R;Wong A;Kuh D;Richards M
• 通讯作者: Richards M

Chronic physical illness in early life and risk of chronic widespread and regional pain at age 68: evidence from the 1946 British birth cohort.

• DOI: 10.1097/j.pain.0000000000000663
• 发表时间: 2016-10
• 期刊: Pain
• 影响因子: 7.4
• 作者: Muthuri SG;Kuh D;Bendayan R;Macfarlane GJ;Cooper R
• 通讯作者: Cooper R