MEASUREMENT OF ENVRIRONMENTAL CHEMICALS IN THE EAGeR TRIAL

EGeER 试验中环境化学物质的测量

• 批准号: 9569856
• 负责人: Kurunthachalam Kannan
• 金额: $ 67.73万
• 依托单位: NYSDOH/HEALTH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-22 至 2019-03-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9569856
• 关键词: Accounting; Adult; Area; Aromatic Polycyclic Hydrocarbons; Aspirin; Benzophenones; Biological Assay; Biological Markers; Chemicals; Contractor; Data; Data Sources; Detection; Dose; Endocrine Disruptors; Endocrine disruption; Evaluation; Exposure to; Fertility; Folic Acid; General Population; Gold; Impairment; Individual; Laboratories; Live Birth; Measurement; Measures; Methods; Occupational Exposure; Outcome; Ovulation; Oxidative Stress; Parabens; Phenols; Pregnancy; Pregnancy Outcome; Pregnancy loss; Property; Prospective Studies; Randomized Controlled Trials; Recording of previous events; Reproduction; Reproductive Health; Research; Risk; Role; Sampling; Serum; Site; Spottings; Testing; Time; Urine; Visit; Woman; Work; adverse pregnancy outcome; cost; environmental chemical; environmental chemical exposure; falls; follow-up; novel; phthalates; pregnant; prospective; repository; reproductive; sample collection; trial design

The Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial is a multi-site, prospective doubleblind randomized controlled trial designed to assess the effects of low-dose aspirin in combination with folic acid treatment on pregnancy and gestation among 1228 women with a history of 1-2 pregnancy losses. A large biospecimen repository is available for analysis and offers a good platform for testing multiple hypotheses. This statement of work is for the measurement of stored biospecimens in the EAGeR Trial. The proposed assays will provide a rich data source on biomarker levels that can answer novel research questions in conjunction with the extensive data already collected in the EAGeR Trial. A growing body of evidence suggests that exposure to many common environmental chemicals, particularly those with endocrine-disrupting properties, may be associated with impaired fecundability and increased risk of adverse pregnancy outcomes. However, much of the findings to date have been equivocal. There is a need to further investigate the potential role of environmental chemical exposures in leading to adverse reproductive and gestational outcomes, particularly among prospective studies with gold standard ascertainment of reproductive and pregnancy outcomes. Due to much prior research being conducted among individuals with occupational exposure, there is also a need for additional research among healthy adults with similar exposure levels to the general population, to ascertain whether background exposure to key environmental chemicals may pose reproductive health risks. Finally, although phenols, such as BPA, and phthalates are known endocrine disruptors, few studies have evaluated their association with reproductive outcomes. There is also a great need for research on emerging endocrine disruptors, including parabens and benzophenones, and reproductive outcomes.

阿司匹林对妊娠和生殖的影响（EAGeR）试验是一项多地点、前瞻性双盲随机对照试验，旨在评估低剂量阿司匹林联合叶酸治疗对1228名有1-2次妊娠史的妇女妊娠和妊娠的影响。大型生物标本库可用于分析，并为测试多种假设提供了良好的平台。本工作说明适用于EAGeR试验中储存的生物标本的测量。拟议的检测将提供丰富的生物标志物水平数据源，结合EAGeR试验中已经收集的大量数据，可以回答新的研究问题。越来越多的证据表明，接触许多常见的环境化学物质，特别是那些具有内分泌干扰特性的化学物质，可能与生育能力受损和不良妊娠结局风险增加有关。然而，迄今为止的许多发现都是模棱两可的。有必要进一步调查环境化学品暴露在导致不利的生殖和妊娠结局方面的潜在作用，特别是在具有确定生殖和妊娠结局金标准的前瞻性研究中。由于之前对职业接触者进行了大量研究，因此还需要对与一般人群接触程度相似的健康成年人进行进一步研究，以确定背景接触关键环境化学品是否可能构成生殖健康风险。最后，虽然酚类物质，如双酚a和邻苯二甲酸盐是已知的内分泌干扰物，但很少有研究评估它们与生殖结果的关系。还非常需要研究新兴的内分泌干扰物，包括对羟基苯甲酸酯和二苯甲酮，以及生殖结果。