Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR)

项目总结/摘要-总体 拟议的沃兹沃斯中心人类健康暴露分析资源（WC-HHEAR）：针对 暴露分析实验室利用一个完善的目标生物监测实验室， 在沃兹沃斯，这是国际公认的世界级公共卫生实验室和研究机构。 沃兹沃斯已经开发出了重要的能力和能力，用于帮助HHEAR进行所需的目标分析 成为一个成功的，并已增加了经验，从一直是六个CHEMICAL实验室中心之一。的 拟议的WC-HHEAR资源由两个具有65年以上综合分析经验的MPI领导 生物标本的有机和无机目标，谁合作，并与其他研究人员 二十年来，我们致力于增进对环境暴露和人类健康的理解;他们的集体 在曝光测量领域发表了700多篇论文。行政 核心将提供有效的基础设施和支持，以确保WC-HHEAR很好地融入 沃兹沃斯环境健康科学部。行政核心的工作人员将努力确认 实验室中心的日常运作顺利，中心内部保持良好的通信， 以及集线器、其他HHEAR组件和HHEAR客户端之间的连接。拟议的WC-HHEAR 目标分析资源（TAR）是本提案的核心，它提供了广泛的功能， 超过30种化学类别和数百个单独的目标，以及许多不同的生物组织和液体。 对HHEAR客户的好处包括与经验丰富的实验室进行多次前后分析咨询 工作人员和主题专家，以高质量的分析工作而闻名。TAR还将利用 沃兹沃斯作为国际水平测试提供商和 生产良好表征的生物参考材料，这将有助于确保数据的统一 世界各地的实验室报告了生物基质中的痕量元素和痕量有机物。WC-HHEAR 开发核心将致力于推进现有的方法，以提高效率，并实现更低的 检测，同时使用越来越小的样品质量/体积。发展核心还将 努力扩展我们在非传统矩阵中的能力，增加测量的目标数量， 更多矩阵此外，WC-HHEAR将适应未来的挑战，无论是由发现驱动， 在非靶向资源中，或来自HHEAR客户端，要求为我们已建立的测定增加通量。

PROJECT SUMMARY / ABSTRACT – OVERALL The proposed Wadsworth Center Human Health Exposure Analysis Resource (WC-HHEAR): Targeted Exposure Analysis Laboratory leverages access to a well-established targeted biomonitoring laboratory based at Wadsworth, which is recognized internationally as a world class public health laboratory and research institute. Wadsworth has developed significant capability and capacity for the targeted analyses required to help HHEAR become a success and has added experience from having been one of the six CHEAR laboratory hubs. The proposed WC-HHEAR resource is led by two MPIs with over 65 years of combined experience analyzing biospecimens for organic and inorganic targets, and who have collaborated together and with other researchers for two decades to advance our understanding of environmental exposures and human health; their collective contributions amount to over 700 published papers in the field of exposure measurements. The Administrative Core will provide an effective infrastructure and the support to ensure that WC-HHEAR is well-integrated into the Wadsworth’s Division of Environmental Health Sciences. Staff from the Administrative Core will work to confirm the day-to-day lab hub operations are smooth, and that excellent communications are maintained within the hub, and between the hub, the other HHEAR components, and with HHEAR clients. The proposed WC-HHEAR Targeted Analysis Resource (TAR), which is at the heart of this proposal, offers extensive capabilities that extend over 30 chemical classes, and hundreds of individual targets, and in many different biological tissues and fluids. The benefit to HHEAR clients includes multiple pre-and-post analytical consultations with experienced laboratory staff and subject matter experts that have reputations for high-quality analytical work. The TAR will also leverage the experience and capability that Wadsworth brings as an international provider of proficiency testing and as a producer of well-characterized biological reference materials that will help ensure the harmonization of data reported by laboratories world-wide for trace elements and trace organics in biological matrices. The WC-HHEAR Development Core will work to advance existing methods to improve efficiency, and achieve lower limits of detection, while working with increasingly smaller sample masses/volumes. The Development Core will also work to extend our capabilities in non-traditional matrices, increasing the number of targets measured and in many more matrices. Additionally, WC-HHEAR will adapt to the challenges ahead, whether driven by discoveries in the untargeted resource, or from HHEAR clients requesting increased throughput for our established assays.