ENVIROMENTAL PHENOLS AND PHTHALATES IN SEMINAL FLUID: IMPLICATIONS FOR MALE FECUNDITY

精液中的环境酚类和邻苯二甲酸盐：对男性生育力的影响

• 批准号: 9149809
• 负责人: Kurunthachalam Kannan
• 金额: $ 29.94万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-23 至 2016-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149809
• 关键词: Analytical Chemistry; Benzophenones; Calibration; Chemicals; Fertility; Human; Label; Learning; Measures; National Institute of Child Health and Human Development; Parabens; Parents; Phenols; Procedures; Process; Protocols documentation; Publishing; Quality Control; Recovery; Reproduction; Sampling; Seminal fluid; Specific qualifier value; Triclosan; bisphenol A; environmental chemical; male; mass spectrometer; phthalates; quality assurance; sperm analysis; sperm cell; urinary

The study shall utilize banked semen samples from the LIFE Study to characterize and quantify a range of non-persistent environmental chemicals. Quantification of the mixture of environmental phenols and phthalates in human seminal fluid will allow assessment of how well urinary concentrations reflect these levels, and allow NICHD to explore the relationship between chemicals present in seminal fluid, semen quality, and couple fecundity.

该研究应利用LIFE研究中储存的精液样本来表征和量化一系列非持久性环境化学物质。对人类精液中环境酚和邻苯二甲酸盐混合物的量化将有助于评估尿液浓度在多大程度上反映这些水平，并使NICHD能够探索精液中存在的化学物质、精液质量和夫妇生育能力之间的关系。