Fourier Ptychographic Endoscopy

 描述(由申请人提供)：为了解决薄临床内窥镜的尺寸、分辨率和视野(FOV)之间的内在权衡，我们提出了一种基于傅立叶投影(FP)技术的新型体层摄影内窥镜。层析内窥镜使用角度变化的照明，将性能扩展到超出光学系统定义的极限。它具有以下主要特点：(1)层析内窥镜系统的可实现分辨率取决于最大入射角，而不是所采用的小型化光学元件的数值孔径(NA)；(2)可以恢复高分辨率样本图像并校正所使用光学元件的剩余像差，从而实现更大的设计空间；(3)可使用恢复的不同深度的高分辨率图像来构建组织形态结构的3D图像；以及(4)在连续照明的情况下，该仪器的工作原理类似于传统的低分辨率内窥镜。当需要高分辨率成像时，它工作在FP模式下，采用顺序脉冲照明。这项建议的目标是开发薄层内窥镜和图像重建算法来演示薄层内窥镜系统，以实现以下目标：(1)开发使用微型化光学元件和照明纤维的薄层内窥镜系统(1-14个月)；(2)开发一个高速图像构建平台，以实时(1-15个月)构建大视场和大景深的高分辨率图像；以及(3)表征和评估层压腔内窥镜系统的成像性能(14-24个月)。CT内窥镜结构紧凑，不需要复杂的系统，只需要一个环形光源，成本也很低。最重要的是，它解决了薄内窥镜的尺寸、分辨率和视野之间的内在权衡。成功完成拟议的体层摄影内窥镜将使我们能够开发出满足未满足的临床需求的薄型内窥镜，使临床医生能够准确地检测和诊断疾病，特别是在准入有限的地区。

 DESCRIPTION (provided by applicant): To address the inherent trade-offs between the size, resolution, and field of view (FOV) of thin clinical endoscopes, we propose a novel ptychographic endoscope based on the Fourier ptychography (FP) technology. Ptychographic endoscope uses angularly varying illumination to extend the performance beyond the limit defined by the optical system. It has the following key features: (1) the achievable resolution of ptychographic endoscopy system is determined by the largest incident angle, not the numerical aperture (NA) of the employed miniaturized optics; (2) it is possible to recover the high resolution sample image and correct for remaining aberrations of the employed optics, enabling a much larger design space; (3) the recovered high-resolution images at different depths can be used to construct a 3D image of the tissue topographic structure; and (4) with continuous illumination, the instrument works as a conventional low resolution endoscope. When high resolution imaging is needed, it works in FP mode with sequential pulse illuminations. The goal of this proposal is to develop thin endoscope and image reconstruction algorithms to demonstrate the ptychographic endoscopy system, by pursuing the following aims: (1) develop the ptychographic endoscopy system using miniaturized optics and illumination fibers (Month 1-14); (2) develop a high speed image construction platform to construct a high-resolution image over large FOV and large depth of field in real time (Month 1-15); and (3) characterize and evaluate the imaging performance of the ptychographic endoscopy system (Month 14-24). Ptychographic endoscope is compact and doesn't require a complicated system, it is also low cost because only a ring illumination source is needed. Most important, it addresses inherent trade-offs between the size, resolution, and FOV of thin endoscopes. Successful completion of the proposed ptychographic endoscope will enable us to develop thin endoscopes for unmet clinical needs by enabling clinicians to accurately detect and diagnosis diseases, particularly in regions with limited access.